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MeSH Review

Disorders of Excessive Somnolence

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Disease relevance of Disorders of Excessive Somnolence


Psychiatry related information on Disorders of Excessive Somnolence


High impact information on Disorders of Excessive Somnolence

  • In patients with severe hypersomnia, slow-wave (stages 3-4) NREM sleep was often reduced, but there were no major REM sleep alterations [9].
  • The hypersomnia of SCN-ablated squirrel monkeys is unique in magnitude, but is not incompatible with a role for the SCN pacemaker in actively promoting sleep [10].
  • Higher levels of depression, hypersomnia, and leaden paralysis were noted in the patients who received haloperidol than in those who received phenelzine and those who received placebo [11].
  • Desipramine in the treatment of hypersomnolence following abrupt cessation of cocaine use [12].
  • These data suggest that the loss of 5-HT neurons of the DRN and the SCN is associated with the presence of hypersomnia in MyD [13].

Chemical compound and disease context of Disorders of Excessive Somnolence

  • When ovulation was inhibited by a combination of ethinylestradiol and lynestrenol, an oral contraceptive pill, the hypersomnia ceased [14].
  • Our findings indicate that modafinil significantly alleviates hypersomnolence (p < 0.05) in the bulldog, as evidenced by dramatically decreased mean total sleep time (from a control value of 50.5% to 8.3% with the drug) and increased mean sleep latency (from a control value of 71.0 minutes to a value of 346.6 minutes with the drug) [15].
  • Pigs injected I.C.V. with 50 ng/kg TNF-alpha showed anorexia, hypersomnia, and an abrupt increase in plasma cortisol concentration [16].
  • Physicians concerned with daytime hypersomnolence in PD patients treated with dopamine agonists and receiving high levodopa dosage equivalents should consider polysomnographic monitoring for impaired daytime sleep latency [17].
  • An important point is emphasized in our case in which the patient reacted unfavorably to Ritalin, becoming sexually aroused, although his hypersomnia improved [18].

Biological context of Disorders of Excessive Somnolence


Anatomical context of Disorders of Excessive Somnolence

  • A new hypothesis claims that, in women with winter SAD, decreased levels of estradiol in the ventromedial hypothalamus are associated with the occurrence of atypical symptoms of depression, including increased daytime sleepiness and hypersomnia during the winter [21].

Gene context of Disorders of Excessive Somnolence


  1. NADPH oxidase mediates hypersomnolence and brain oxidative injury in a murine model of sleep apnea. Zhan, G., Serrano, F., Fenik, P., Hsu, R., Kong, L., Pratico, D., Klann, E., Veasey, S.C. Am. J. Respir. Crit. Care Med. (2005) [Pubmed]
  2. The endocrinology of melancholic and atypical depression: relation to neurocircuitry and somatic consequences. Gold, P.W., Chrousos, G.P. Proc. Assoc. Am. Physicians (1999) [Pubmed]
  3. Paradoxical response to nitrazepam in a patient with hypersomnia secondary to nocturnal myoclonus. Nassr, D.G. Journal of clinical psychopharmacology. (1986) [Pubmed]
  4. Cerebrospinal fluid homovanillic acid and 5-hydroxyindoleacetic acid in hypersomnia with periodic apneas or idiopathic hypersomnia: preliminary results. Baruzzi, A., Cirignotta, F., Coccagna, G., Calderini, G., Lugaresi, E. Sleep. (1980) [Pubmed]
  5. Narcolepsy and idiopthic hypersomnia: biogenic amines and related compounds in CSF. Montplaisir, J., de Champlain, J., Young, S.N., Missala, K., Sourkes, T.L., Walsh, J., Rémillard, G. Neurology (1982) [Pubmed]
  6. Modafinil induces wakefulness without intensifying motor activity or subsequent rebound hypersomnolence in the rat. Edgar, D.M., Seidel, W.F. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  7. CSF hypocretin-1 levels in narcolepsy, Kleine-Levin syndrome, and other hypersomnias and neurological conditions. Dauvilliers, Y., Baumann, C.R., Carlander, B., Bischof, M., Blatter, T., Lecendreux, M., Maly, F., Besset, A., Touchon, J., Billiard, M., Tafti, M., Bassetti, C.L. J. Neurol. Neurosurg. Psychiatr. (2003) [Pubmed]
  8. Autoantibodies to a 68/48 kDa protein in chronic fatigue syndrome and primary fibromyalgia: a possible marker for hypersomnia and cognitive disorders. Nishikai, M., Tomomatsu, S., Hankins, R.W., Takagi, S., Miyachi, K., Kosaka, S., Akiya, K. Rheumatology (Oxford, England) (2001) [Pubmed]
  9. Hypersomnia following paramedian thalamic stroke: a report of 12 patients. Bassetti, C., Mathis, J., Gugger, M., Lovblad, K.O., Hess, C.W. Ann. Neurol. (1996) [Pubmed]
  10. Circadian regulation of sleep in mammals: role of the suprachiasmatic nucleus. Mistlberger, R.E. Brain Res. Brain Res. Rev. (2005) [Pubmed]
  11. Continuation pharmacotherapy of borderline personality disorder with haloperidol and phenelzine. Cornelius, J.R., Soloff, P.H., Perel, J.M., Ulrich, R.F. The American journal of psychiatry. (1993) [Pubmed]
  12. Desipramine in the treatment of hypersomnolence following abrupt cessation of cocaine use. Baxter, L.R. The American journal of psychiatry. (1983) [Pubmed]
  13. Loss of serotonin-containing neurons in the raphe of patients with myotonic dystrophy: a quantitative immunohistochemical study and relation to hypersomnia. Ono, S., Takahashi, K., Jinnai, K., Kanda, F., Fukuoka, Y., Kurisaki, H., Mitake, S., Inagaki, T., Yamano, T., Nagao, K. Neurology (1998) [Pubmed]
  14. Menstruation-related periodic hypersomnia: a case study with successful treatment. Sachs, C., Persson, H.E., Hagenfeldt, K. Neurology (1982) [Pubmed]
  15. Modafinil decreases hypersomnolence in the English bulldog, a natural animal model of sleep-disordered breathing. Panckeri, K.A., Schotland, H.M., Pack, A.I., Hendricks, J.C. Sleep. (1996) [Pubmed]
  16. Coincidental changes in behavior and plasma cortisol in unrestrained pigs after intracerebroventricular injection of tumor necrosis factor-alpha. Warren, E.J., Finck, B.N., Arkins, S., Kelley, K.W., Scamurra, R.W., Murtaugh, M.P., Johnson, R.W. Endocrinology (1997) [Pubmed]
  17. Predictors of impaired daytime sleep and wakefulness in patients with Parkinson disease treated with older (ergot) vs newer (nonergot) dopamine agonists. Razmy, A., Lang, A.E., Shapiro, C.M. Arch. Neurol. (2004) [Pubmed]
  18. The Kleine-Levine syndrome--a variant? Yassa, R., Nair, N.P. The Journal of clinical psychiatry. (1978) [Pubmed]
  19. Frequency of narcolepsy symptoms and other sleep disorders in narcoleptic patients and their first-degree relatives. Ohayon, M.M., Ferini-Strambi, L., Plazzi, G., Smirne, S., Castronovo, V. Journal of sleep research. (2005) [Pubmed]
  20. Does abnormal neuronal excitability exist in myotonic dystrophy? I. Effects of the antiarrhythmic drug hydroquinidine on slow saccadic eye movements. Di Costanzo, A., Mottola, A., Toriello, A., Di Iorio, G., Tedeschi, G., Bonavita, V. Neurol. Sci. (2000) [Pubmed]
  21. Estrogen could control photoperiodic adjustment in seasonal affective disorder. Partonen, T. Med. Hypotheses (1995) [Pubmed]
  22. Hypersomnia, bithalamic lesions, and altered sleep architecture in Kearns-Sayre syndrome. Kotagal, S., Archer, C.R., Walsh, J.K., Gomez, C. Neurology (1985) [Pubmed]
  23. The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias. Mignot, E., Lammers, G.J., Ripley, B., Okun, M., Nevsimalova, S., Overeem, S., Vankova, J., Black, J., Harsh, J., Bassetti, C., Schrader, H., Nishino, S. Arch. Neurol. (2002) [Pubmed]
  24. Menstrual-associated sleep disorder: an unusual hypersomniac variant associated with both menstruation and amenorrhea with a possible link to prolactin and metoclopramide. Bamford, C.R. Sleep. (1993) [Pubmed]
  25. Excessive daytime somnolence and increased rapid eye movement pressure in myotonic dystrophy. Gibbs, J.W., Ciafaloni, E., Radtke, R.A. Sleep. (2002) [Pubmed]
  26. Reducing relapse in depressed outpatients with atypical features: a pilot study. Jarrett, R.B., Kraft, D., Schaffer, M., Witt-Browder, A., Risser, R., Atkins, D.H., Doyle, J. Psychotherapy and psychosomatics. (2000) [Pubmed]
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