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MeSH Review

Persistent Vegetative State

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Disease relevance of Persistent Vegetative State


Psychiatry related information on Persistent Vegetative State


High impact information on Persistent Vegetative State


Chemical compound and disease context of Persistent Vegetative State

  • Of prognostic importance, patients with increased lactate were more likely to be severely disabled (39% vs 10%), survive in a persistent vegetative state (13% vs 2%), or have died (39% vs 7%) [14].
  • The peak value of EAAs in the poor-outcome group (including severe disability, vegetative state, and death) was significantly higher than in the good-outcome group (good recovery and moderate disability; Glu, P <0.001; Asp, P <0.01); GOS was closely correlated to the EAA values (Glu, rs = 0.5737, P <0.001; Asp, rs = 0.5470, P <0.001) [15].
  • It was found that the coupling between neuronal electrical activity and regional glucose metabolism was preserved in all the minimally conscious patients but was absent in all the vegetative state patients [16].
  • The outcome was significantly better in the patients with a good or partial ICP response to pentobarbital, with 21% of these patients having a good recovery or moderate disability at 3 months after injury, compared with 100% persistent vegetative state or death in the nonresponders [17].
  • Twenty-four-hour profiles of growth hormone, prolactin and cortisol in the chronic vegetative state [18].

Biological context of Persistent Vegetative State

  • Eye movements induced by head rotation were studied in 6 patients in acute coma, 4 patients in a persistent vegetative state, and 6 healthy, alert control subjects [19].
  • Evoked potentials for the prediction of vegetative state in the acute stage of coma [20].
  • There is now evidence that coma and vegetative states are sometimes reversible with a combination of treatments, among them neuropharmacology [21].
  • A clinico-physiological study of visually evoked potential (VEP) and somatosensory evoked potential (SEP) in so-called vegetative state and delta coma [22].
  • An nonlinear indicator of Functional Isolation, named approximated entropy (ApEn), assessed within cerebral cortex in patients with a vegetative state it's recently found as a promising tool for the prediction of recovery. The theoretical framework arise from a simple assumption: since we still have not found the [neural correlates of consciousness] it may be beneficial to use an "indirect extimator" of the mean functional isolation degree within the cerebral cortex of patients. By this way it's possible to test not only a well defined circuitery in the brain cortex but also the "ghost networks". This is because a diffuse functional isolation shot out the arising of whichever possible wide functional neuronal's ensamble (with both a well and not defined "anatomy") [23] [24]

Anatomical context of Persistent Vegetative State


Gene context of Persistent Vegetative State


Analytical, diagnostic and therapeutic context of Persistent Vegetative State


  1. A prospective study of nontraumatic coma: methods and results in 310 patients. Bates, D., Caronna, J.J., Cartlidge, N.E., Knill-Jones, R.P., Levy, D.E., Shaw, D.A., Plum, F. Ann. Neurol. (1977) [Pubmed]
  2. Vegetative state after closed-head injury. A Traumatic Coma Data Bank Report. Levin, H.S., Saydjari, C., Eisenberg, H.M., Foulkes, M., Marshall, L.F., Ruff, R.M., Jane, J.A., Marmarou, A. Arch. Neurol. (1991) [Pubmed]
  3. A comparison of manual and semi-automated methods in the assessment of axonal injury. Gentleman, S.M., McKenzie, J.E., Royston, M.C., McIntosh, T.K., Graham, D.I. Neuropathol. Appl. Neurobiol. (1999) [Pubmed]
  4. Global workspace theory of consciousness: toward a cognitive neuroscience of human experience. Baars, B.J. Prog. Brain Res. (2005) [Pubmed]
  5. Anticruelty care: commentary. Braithwaite, S.S. The Journal of clinical ethics. (1991) [Pubmed]
  6. Persistent vegetative state with high cerebral blood flow following profound hypoglycemia. Agardh, C.D., Rosén, I., Ryding, E. Ann. Neurol. (1983) [Pubmed]
  7. MR Imaging of nonalcoholic Wernicke encephalopathy: a follow-up study. Zhong, C., Jin, L., Fei, G. AJNR. American journal of neuroradiology. (2005) [Pubmed]
  8. Acetazolamide vasoreactivity in vascular dementia and persistent vegetative state evaluated by transcranial harmonic perfusion imaging and Doppler sonography. Shiogai, T., Uebo, C., Makino, M., Mizuno, T., Nakajima, K., Furuhata, H. Ann. N. Y. Acad. Sci. (2002) [Pubmed]
  9. Artificial feeding--solid ground, not a slippery slope. Steinbrook, R., Lo, B. N. Engl. J. Med. (1988) [Pubmed]
  10. Hyponatremia, convulsions, respiratory arrest, and permanent brain damage after elective surgery in healthy women. Arieff, A.I. N. Engl. J. Med. (1986) [Pubmed]
  11. Identification by positron emission tomography of neuronal loss in acute vegetative state. Rudolf, J., Sobesky, J., Grond, M., Heiss, W.D. Lancet (2000) [Pubmed]
  12. Cortical processing in persistent vegetative state. Wolfson Brain Imaging Centre Team. Menon, D.K., Owen, A.M., Williams, E.J., Minhas, P.S., Allen, C.M., Boniface, S.J., Pickard, J.D. Lancet (1998) [Pubmed]
  13. Association of apolipoprotein E polymorphism with outcome after head injury. Teasdale, G.M., Nicoll, J.A., Murray, G., Fiddes, M. Lancet (1997) [Pubmed]
  14. 1H-magnetic resonance spectroscopy-determined cerebral lactate and poor neurological outcomes in children with central nervous system disease. Ashwal, S., Holshouser, B.A., Tomasi, L.G., Shu, S., Perkin, R.M., Nystrom, G.A., Hinshaw, D.B. Ann. Neurol. (1997) [Pubmed]
  15. Excitatory amino acids in cerebrospinal fluid of patients with acute head injuries. Zhang, H., Zhang, X., Zhang, T., Chen, L. Clin. Chem. (2001) [Pubmed]
  16. Neurometabolic coupling in the vegetative and minimally conscious states: preliminary findings. Coleman, M.R., Menon, D.K., Fryer, T.D., Pickard, J.D. J. Neurol. Neurosurg. Psychiatr. (2005) [Pubmed]
  17. Cerebral hemodynamic effects of pentobarbital coma in head-injured patients. Cormio, M., Gopinath, S.P., Valadka, A., Robertson, C.S. J. Neurotrauma (1999) [Pubmed]
  18. Twenty-four-hour profiles of growth hormone, prolactin and cortisol in the chronic vegetative state. Vogel, H.P., Kroll, M., Fritschka, E., Quabbe, H.J. Clin. Endocrinol. (Oxf) (1990) [Pubmed]
  19. Eye movements induced by head rotation in unresponsive patients. Leigh, R.J., Hanley, D.F., Munschauer, F.E., Lasker, A.G. Ann. Neurol. (1984) [Pubmed]
  20. Evoked potentials for the prediction of vegetative state in the acute stage of coma. Fischer, C., Luauté, J. Neuropsychological rehabilitation. (2005) [Pubmed]
  21. Post-acute management of head injuries. Stonnington, H.H. Virginia medical quarterly : VMQ. (1991) [Pubmed]
  22. A clinico-physiological study of visually evoked potential (VEP) and somatosensory evoked potential (SEP) in so-called vegetative state and delta coma. Kawamura, H., Kubota, S., Asakura, T., Kitamura, K. Neurol. Med. Chir. (Tokyo) (1975) [Pubmed]
  23. Functional isolation within the cerebral cortex in the vegetative state: a nonlinear method to predict clinical outcomes. Sarà, M., Pistoia, F., Pasqualetti, P., Sebastiano, F., Onorati, P., Rossini, P.M. Neurorehabil. Neural. Repair. (2011) [Pubmed]
  24. Complexity loss in physiological time series of patients in a vegetative state. Sarà, M., Pistoia, F. Nonlinear. Dynamics. Psychol. Life. Sci. (2010) [Pubmed]
  25. Posttraumatic cerebral hemispheric disconnection syndrome. Rubens, A.B., Geschwind, N., Mahowald, M.W., Mastri, A. Arch. Neurol. (1977) [Pubmed]
  26. Mutational analysis and genotype-phenotype correlation of 29 unrelated Japanese patients with X-linked adrenoleukodystrophy. Takano, H., Koike, R., Onodera, O., Sasaki, R., Tsuji, S. Arch. Neurol. (1999) [Pubmed]
  27. New aspects of immunotherapy of leptomeningeal metastasis. Herrlinger, U., Weller, M., Schabet, M. J. Neurooncol. (1998) [Pubmed]
  28. From locus to cellular disturbances: positional cloning of the infantile neuronal ceroid lipofuscinosis gene. Hellsten, E., Vesa, J., Jalanko, A., Peltonen, L. Neuropediatrics. (1997) [Pubmed]
  29. Persistent vegetative state in Alzheimer disease. Does it exist? Volicer, L., Berman, S.A., Cipolloni, P.B., Mandell, A. Arch. Neurol. (1997) [Pubmed]
  30. Tyrosine hydroxylase and norepinephrine transporter mRNA expression in the locus coeruleus in Alzheimer's disease. Szot, P., Leverenz, J.B., Peskind, E.R., Kiyasu, E., Rohde, K., Miller, M.A., Raskind, M.A. Brain Res. Mol. Brain Res. (2000) [Pubmed]
  31. Gardner; re BWV: Victorian Supreme Court makes landmark Australian ruling on tube feeding. Ashby, M.A., Mendelson, D. Med. J. Aust. (2004) [Pubmed]
  32. The Coma Exit Chart: assessing the patient in prolonged coma and the vegetative state. Freeman, E.A. Brain injury : [BI]. (1996) [Pubmed]
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