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Disease relevance of Parapoxvirus

  • Recently, a gene encoding a polypeptide with about 25% amino acid identity to mammalian VEGF was identified in the genome of Orf virus (OV), a parapoxvirus that affects sheep and goats and occasionally, humans, to generate lesions with angiogenesis [1].
  • A gene encoding a polypeptide with homology to interleukin-10 (IL-10) has been discovered in the genome of orf virus (OV) strain NZ2, a parapoxvirus that infects sheep, goats, and humans [2].
  • Purified virions of milker's nodule virus, a parapoxvirus, were shown to contain an RNA polymerase, a nucleotide phosphohydrolase, and a protein kinase associated with or encapsulated within the DNA-containing core of the virus [3].

High impact information on Parapoxvirus


Chemical compound and disease context of Parapoxvirus


Gene context of Parapoxvirus


  1. A novel type of vascular endothelial growth factor, VEGF-E (NZ-7 VEGF), preferentially utilizes KDR/Flk-1 receptor and carries a potent mitotic activity without heparin-binding domain. Ogawa, S., Oku, A., Sawano, A., Yamaguchi, S., Yazaki, Y., Shibuya, M. J. Biol. Chem. (1998) [Pubmed]
  2. A homolog of interleukin-10 is encoded by the poxvirus orf virus. Fleming, S.B., McCaughan, C.A., Andrews, A.E., Nash, A.D., Mercer, A.A. J. Virol. (1997) [Pubmed]
  3. Some enzymatic activities associated with purified parapoxvirions. Caplen, H.S., Holowczak, J.A. J. Virol. (1983) [Pubmed]
  4. Viral vascular endothelial growth factors vary extensively in amino acid sequence, receptor-binding specificities, and the ability to induce vascular permeability yet are uniformly active mitogens. Wise, L.M., Ueda, N., Dryden, N.H., Fleming, S.B., Caesar, C., Roufail, S., Achen, M.G., Stacker, S.A., Mercer, A.A. J. Biol. Chem. (2003) [Pubmed]
  5. Real-time PCR detection of parapoxvirus DNA. Nitsche, A., Büttner, M., Wilhelm, S., Pauli, G., Meyer, H. Clin. Chem. (2006) [Pubmed]
  6. The Orf virus E3L homologue is able to complement deletion of the vaccinia virus E3L gene in vitro but not in vivo. Vijaysri, S., Talasela, L., Mercer, A.A., Mcinnes, C.J., Jacobs, B.L., Langland, J.O. Virology (2003) [Pubmed]
  7. Parapoxvirus infection in harbor seals (Phoca vitulina) from the German North Sea. Müller, G., Gröters, S., Siebert, U., Rosenberger, T., Driver, J., König, M., Becher, P., Hetzel, U., Baumgärtner, W. Vet. Pathol. (2003) [Pubmed]
  8. Parapoxviruses are strongly inhibited in vitro by cidofovir. Nettleton, P.F., Gilray, J.A., Reid, H.W., Mercer, A.A. Antiviral Res. (2000) [Pubmed]
  9. Sequence and functional analysis of a homolog of interleukin-10 encoded by the parapoxvirus orf virus. Fleming, S.B., Haig, D.M., Nettleton, P., Reid, H.W., McCaughan, C.A., Wise, L.M., Mercer, A. Virus Genes (2000) [Pubmed]
  10. Infection with parapoxvirus induces CD30-positive cutaneous infiltrates in humans. Rose, C., Starostik, P., Bröcker, E.B. J. Cutan. Pathol. (1999) [Pubmed]
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