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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Ecthyma, Contagious

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Disease relevance of Ecthyma, Contagious

  • Furthermore, the ability of enterocytes to activate V beta 6+ Mls1a-specific T cells was inhibited by monoclonal antibodies against the Orf protein encoded by an Mtv-7 provirus which is associated with Mls1a expression [1].
  • WDSV encodes a putative cyclin homologue, Orf A, and six variant Orf A transcripts have been identified [2].
  • The neuA (Orf 25) and neuB (Orf 24) gene products were functionally characterized by complementation of the capsule negative E. coli K1 mutants EV5 and EV24, respectively [3].

High impact information on Ecthyma, Contagious

  • Mass spectrometry of purified active Orf* confirmed the presence of 4'-phosphopantetheine and 27-hydroxyoctacosanoic acid in the major species [4].
  • Orf* is a new kind of acyl carrier protein because it is only approximately 25% identical both to the constitutive acyl carrier protein (AcpP) and to the inducible acyl carrier protein (NodF) of R. leguminosarum [4].
  • Orf virus encodes a novel secreted protein inhibitor of granulocyte-macrophage colony-stimulating factor and interleukin-2 [5].
  • We prepared 125I-labeled cyclosporine (125I-CS) by modifying the procedure of Mahoney and Orf (Clin Chem 1985;31:459) and characterized it with regards to maximal immunoreactivity (greater than 90%), trichloroacetic acid precipitability (greater than 90%), and stability (90% immunoreactive after five half-lives of 125I) [6].
  • Cells transiently expressing Orf C exhibited apoptotic morphology and increased levels of surface phosphatidylserine and were unable to retain MitoTracker Orange, a dye that accumulates in active mitochondria [7].

Chemical compound and disease context of Ecthyma, Contagious


Biological context of Ecthyma, Contagious


Gene context of Ecthyma, Contagious

  • We have examined this sequence disparity by determining the VEGF gene sequence of 21 isolates of Orf virus derived from diverse sources [12].
  • Orf virus encodes a functional dUTPase gene [13].
  • We previously reported the identification of a USDA 110 Tn5 mutant, strain D4.2-5, that had the ability to overcome nodulation restriction conditioned by PI 417566 (S. M. Lohrke, J. H. Orf, E. Martínez-Romero, and M. J. Sadowsky, Appl. Environ. Microbiol. 61:2378-2383, 1995) [14].


  1. Mouse intestinal epithelial cells express the self superantigen Mls1a. Kaiserlian, D., Vidal, K., MacDonald, H.R., Grosjean, I. Eur. J. Immunol. (1993) [Pubmed]
  2. Intracellular targeting of walleye dermal sarcoma virus Orf A (rv-cyclin). Rovnak, J., Casey, J.W., Quackenbush, S.L. Virology (2001) [Pubmed]
  3. Cloning and functional characterization of a 30 kb gene locus required for lipopolysaccharide biosynthesis in Legionella pneumophila. Lüneberg, E., Zetzmann, N., Alber, D., Knirel, Y.A., Kooistra, O., Zähringer, U., Frosch, M. Int. J. Med. Microbiol. (2000) [Pubmed]
  4. A special acyl carrier protein for transferring long hydroxylated fatty acids to lipid A in Rhizobium. Brozek, K.A., Carlson, R.W., Raetz, C.R. J. Biol. Chem. (1996) [Pubmed]
  5. Orf virus encodes a novel secreted protein inhibitor of granulocyte-macrophage colony-stimulating factor and interleukin-2. Deane, D., McInnes, C.J., Percival, A., Wood, A., Thomson, J., Lear, A., Gilray, J., Fleming, S., Mercer, A., Haig, D. J. Virol. (2000) [Pubmed]
  6. Radioimmunoassay of salivary cyclosporine with use of 125I-labeled cyclosporine. Coates, J.E., Lam, S.F., McGaw, W.T. Clin. Chem. (1988) [Pubmed]
  7. Walleye dermal sarcoma virus Orf C is targeted to the mitochondria. Nudson, W.A., Rovnak, J., Buechner, M., Quackenbush, S.L. J. Gen. Virol. (2003) [Pubmed]
  8. Polymerase chain reaction for laboratory diagnosis of orf virus infections. Torfason, E.G., Gunadóttir, S. J. Clin. Virol. (2002) [Pubmed]
  9. Chromium-51-release assay of antibody and complement-mediated cytotoxicity for contagious ecthyma virus-infected cells. DeMartini, J.C., Pearson, L.D., Fiscus, S.A. Am. J. Vet. Res. (1978) [Pubmed]
  10. Immune response of lambs to experimental infection with Orf virus. Yirrell, D.L., Reid, H.W., Norval, M., Howie, S.E. Vet. Immunol. Immunopathol. (1989) [Pubmed]
  11. Attempted reactivation of contagious ecthyma in Dall sheep. Zarnke, R.L., Dieterich, R.A. Am. J. Vet. Res. (1985) [Pubmed]
  12. Vascular endothelial growth factors encoded by Orf virus show surprising sequence variation but have a conserved, functionally relevant structure. Mercer, A.A., Wise, L.M., Scagliarini, A., McInnes, C.J., Büttner, M., Rziha, H.J., McCaughan, C.A., Fleming, S.B., Ueda, N., Nettleton, P.F. J. Gen. Virol. (2002) [Pubmed]
  13. Orf virus encodes a functional dUTPase gene. Cottone, R., Büttner, M., McInnes, C.J., Wood, A.R., Rziha, H.J. J. Gen. Virol. (2002) [Pubmed]
  14. The Bradyrhizobium japonicum noeD gene: a negatively acting, genotype-specific nodulation gene for soybean. Lohrke, S.M., Day, B., Kolli, V.S., Hancock, R., Yuen, J.P., de Souza, M.L., Stacey, G., Carlson, R., Tong, Z., Hur, H.G., Orf, J.H., Sadowsky, M.J. Mol. Plant Microbe Interact. (1998) [Pubmed]
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