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Disease relevance of Hyperacusis


Psychiatry related information on Hyperacusis

  • A sister and brother, now aged 7 and 9 years, presented with developmental arrest, gait disturbance, dementia, and a progressive myoclonic epilepsy syndrome with hyperacusis in the second year of life [5].
  • OBJECTIVE: This study examined relationships among sound level, subjective loudness, and reaction time in listeners with longstanding sensorineural hearing loss and loudness recruitment [6].

High impact information on Hyperacusis


Chemical compound and disease context of Hyperacusis


Gene context of Hyperacusis

  • In particular, it is shown quantitatively that a compressed distribution of thresholds due to threshold elevation may be responsible for loudness recruitment in sensorineural hearing loss [15].
  • Additional mechanisms that may mediate hyperacusis in WS and should be evaluated in future studies include recruitment, malformation of the facial canal, and haploinsufficiency of the elastin gene [4].


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  2. Almotriptan: a review of its use in migraine. Keam, S.J., Goa, K.L., Figgitt, D.P. Drugs (2002) [Pubmed]
  3. Central hyperacusis with phonophobia in multiple sclerosis. Weber, H., Pfadenhauer, K., Stöhr, M., Rösler, A. Mult. Scler. (2002) [Pubmed]
  4. Hyperacusis in Williams syndrome: characteristics and associated neuroaudiologic abnormalities. Gothelf, D., Farber, N., Raveh, E., Apter, A., Attias, J. Neurology (2006) [Pubmed]
  5. GM1 gangliosidosis type 2 in two siblings. Gascon, G.G., Ozand, P.T., Erwin, R.E. J. Child Neurol. (1992) [Pubmed]
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  8. Zolmitriptan: a review of its use in migraine. Spencer, C.M., Gunasekara, N.S., Hills, C. Drugs (1999) [Pubmed]
  9. The prophylactic effect of valproate on glyceryltrinitrate induced migraine. Tvedskov, J.F., Thomsen, L.L., Iversen, H.K., Gibson, A., Wiliams, P., Olesen, J. Cephalalgia : an international journal of headache. (2004) [Pubmed]
  10. Efficacy of phenazone in the treatment of acute migraine attacks: a double-blind, placebo-controlled, randomized study. Göbel, H., Heinze, A., Niederberger, U., Witt, T., Zumbroich, V. Cephalalgia : an international journal of headache. (2004) [Pubmed]
  11. Valdecoxib for treatment of a single, acute, moderate to severe migraine headache. Kudrow, D., Thomas, H.M., Ruoff, G., Ishkanian, G., Sands, G., Le, V.H., Brown, M.T. Headache. (2005) [Pubmed]
  12. Is central hyperacusis a symptom of 5-hydroxytryptamine (5-HT) dysfunction? Marriage, J., Barnes, N.M. The Journal of laryngology and otology. (1995) [Pubmed]
  13. A comparison of odor perception in smokers, nonsmokers, and passive smokers. Ahlström, R., Berglund, B., Berglund, U., Engen, T., Lindvall, T. American journal of otolaryngology. (1987) [Pubmed]
  14. Acute migraine treatment with droperidol: A randomized, double-blind, placebo-controlled trial. Silberstein, S.D., Young, W.B., Mendizabal, J.E., Rothrock, J.F., Alam, A.S. Neurology (2003) [Pubmed]
  15. Binaural loudness matches in unilaterally impaired listeners. Zeng, F.G., Turner, C.W. The Quarterly journal of experimental psychology. A, Human experimental psychology. (1991) [Pubmed]
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