Disease relevance of Hearing Loss, Noise-Induced

• Piribedil (a D3/D2/D1 agonist), a drug under investigation, known to prevent acoustic trauma or ischaemia-induced hearing loss, had a similar and concentration-dependent increasing effect on both resting and evoked release of dopamine [1].
• Occupational diseases affect all organ systems and include pulmonary disease, musculoskeletal injuries, occupational cancer, traumatic injuries, occupationally induced cardiovascular disease, disorders of reproduction, neurotoxic disorders, noise-induced hearing loss, dermatologic conditions, and psychological disorders [2].
• CONCLUSION:: Gabapentin is effective in reducing subjective and objective aspects of tinnitus in some individuals, with the best therapeutic response obtained in individuals with associated acoustic trauma [3].
• The causes of sensorineural loss addressed include acoustic trauma, aminoglycoside ototoxicity, intoxication with loop diuretics, hypoxia and Meniere's disease [4].
• Biochemical research gradually is unlocking the mysteries of otosclerosis, Paget's disease, endolymphatic hydrops, ototoxicity, acoustic trauma, presbycusis, and other forms of sensorineural hearing loss [5].

High impact information on Hearing Loss, Noise-Induced

• Noise-induced hearing loss: the future is hear. Cochlear pharmacology and noise trauma: prevention and progress-a joint symposium organized by The Novartis Foundation and the European Commission Concerted Action Against Noise. The Novartis Foundation London, UK, 1-2 May 1998 [6].
• All of these responses are significantly impaired following acoustic trauma and/or exposure to a variety of ototoxic agents including aminoglycoside antibiotics, loop diuretics, antithyroid and antitumor drugs (alpha-difluoromethylornithine) and excitatory amino acids [7].
• Paraoxonase and superoxide dismutase gene polymorphisms and noise-induced hearing loss [8].
• We demonstrate how GR can directly modulate hearing sensitivity in response to a moderate acoustic trauma that results in a hearing loss (10-30 dB) [9].
• The local application of the calcineurin inhibitors, FK506 and cyclosporin A, reduced the level of noise-induced auditory brain stem response threshold shift and hair cell death, indicating that calcineurin is a factor in noise-induced hearing loss [10].

Chemical compound and disease context of Hearing Loss, Noise-Induced

• PBN treatment significantly reduced the physiological and morphological cochlear differences which were observed between DEX and control rats after acoustic trauma [11].
• Riluzole rescues cochlear sensory cells from acoustic trauma in the guinea-pig [12].
• Since dopamine is thought to protect the afferent nerve fibres from damage due to acoustic trauma or ischaemia, enhancement of the release of dopamine, a potential therapeutic site of these injuries, was investigated [1].
• We conclude that vitamin A deficiency increases the sensitivity of the inner ear to noise and that this increased sensitivity increases the probability of noise-induced hearing loss [13].
• Predicting exposure conditions that facilitate the potentiation of noise-induced hearing loss by carbon monoxide [14].

Biological context of Hearing Loss, Noise-Induced

• As a first step toward elucidating the mechanism underlying the therapeutic effect of glucocorticoids on acute noise-induced hearing loss, we used semiquantitative reverse transcription polymerase chain reaction to study the level of glucocorticoid receptor (GR) mRNA in the cochlea of the guinea pig after acoustic overstimulation [15].
• DNA labeling with tritiated thymidine has shown that the restoration of cell number following acoustic trauma results from the production of new hair cells by mitotic division [16].
• It is concluded that although there is a modest relationship between eye color (melanin content) and susceptibility to noise-induced hearing loss, this relationship is less apparent in populations exposed to noise levels below 110 dB (re HTL) [17].
• Hearing loss can be caused by a variety of insults, including acoustic trauma and exposure to ototoxins, that principally effect the viability of sensory hair cells via the MAP kinase (MAPK) cell death signaling pathway that incorporates c-Jun N-terminal kinase (JNK) [18].
• CONCLUSIONS: Rapid recovery from acoustic trauma was temporally correlated with urodynamic and cardiovascular reactions from ingesting food containing sulfite preservative, a substance to which the individual was allergic [19].

Anatomical context of Hearing Loss, Noise-Induced

• In addition, acoustic trauma resulted in a massive outer hair cell loss in the DEX rats compared to minor loss in the normal rats [11].
• The other is of more recent vintage, and involves the use of calpain inhibitors to protect sensory hair cells and spiral ganglion neurons from damage associated with acoustic trauma, this latter in collaboration with Dr. R [20].
• Nerve endings and nerve fibers generally were resistant to both acoustic trauma and kanamycin intoxication, and their degeneration appears to be secondary to the sensory cell degeneration [21].
• Acoustic trauma caused loss of 240 and 2160 inner hair cells in the groups injected with bFGF and saline, respectively [22].
• Cochlear implantation trauma and noise-induced hearing loss both involve a physical disruption of the organ of Corti and may involve several mechanisms of cell death at the molecular level, i.e., necrosis, necrosis-like programmed cell death (PCD; type 2 PCD), and apoptosis (type 1 PCD) [23].

Gene context of Hearing Loss, Noise-Induced

• Following acoustic trauma, regenerated hair cells acquired BDNF mRNA expression at early stages of differentiation [24].
• Noise-induced hearing loss in 11-12-week-old mice heterozygous for a null allele of Myo7a ( Myo7a(4626SB)) is not significantly different from wild-type littermates [25].
• Vascular endothelial growth factor (VEGF) expression in noise-induced hearing loss [26].
• CDH23 is the first gene known to cause deafness in the human population to be linked with predisposition to noise-induced hearing loss [25].
• Progressive hearing loss and increased susceptibility to noise-induced hearing loss in mice carrying a Cdh23 but not a Myo7a mutation [25].

Analytical, diagnostic and therapeutic context of Hearing Loss, Noise-Induced

• CONCLUSION: These data indicate isoflurane general anesthesia protects against noise-induced hearing loss and tissue damage in mice [27].
• This study may serve as a basis for future clinical trials of leupeptin administration for the prevention or treatment of noise-induced hearing loss and the management of tinnitus [28].
• Repeated intraperitoneal injection of carnosine in a dose of 200 mg/kg 12 and 0.5 h before modeling of acute acoustic trauma decreased the severity of degenerative and atrophic changes in the nuclei of hair cells in the cochleae [29].
• Tympanoplasty can cause a sensorineural hearing loss by a mechanism of acoustic trauma [30].

References