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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Photophobia


Psychiatry related information on Photophobia


High impact information on Photophobia


Chemical compound and disease context of Photophobia

  • Light sensitivity of the opsin pigment is restored through a multistep pathway called the visual cycle, which effects all-trans to 11-cis re-isomerization of the retinoid chromophore [12].
  • The increased light sensitivity of the transformants appears to result from a limitation in photochemical energy utilization and/or dissipation which correlates with a greatly diminished photosynthetic response to exogenous (CO2 + HCO3-), especially under conditions where the chloroplast inorganic carbon transport system is not induced [13].
  • Mutant seeds had more rapid germination, reduced requirement for light, and decreased far-red light sensitivity, unraveling cytokinin functions in seed germination control [14].
  • Subsequent inactivation of apcE by an erythromycin resistance marker led to reduction of the phycobilin-to-chlorophyll ratio and to a further decrease in light sensitivity [15].
  • Photoreception in Neurospora crassa: correlation of reduced light sensitivity with flavin deficiency [16].

Biological context of Photophobia


Anatomical context of Photophobia


Gene context of Photophobia


Analytical, diagnostic and therapeutic context of Photophobia


  1. Total colourblindness is caused by mutations in the gene encoding the alpha-subunit of the cone photoreceptor cGMP-gated cation channel. Kohl, S., Marx, T., Giddings, I., Jägle, H., Jacobson, S.G., Apfelstedt-Sylla, E., Zrenner, E., Sharpe, L.T., Wissinger, B. Nat. Genet. (1998) [Pubmed]
  2. Psb29, a conserved 22-kD protein, functions in the biogenesis of Photosystem II complexes in Synechocystis and Arabidopsis. Keren, N., Ohkawa, H., Welsh, E.A., Liberton, M., Pakrasi, H.B. Plant Cell (2005) [Pubmed]
  3. Efficacy and safety of acetaminophen in the treatment of migraine: results of a randomized, double-blind, placebo-controlled, population-based study. Lipton, R.B., Baggish, J.S., Stewart, W.F., Codispoti, J.R., Fu, M. Arch. Intern. Med. (2000) [Pubmed]
  4. Phase I-II clinical and pharmacologic studies of high-dose cytosine arabinoside in refractory leukemia. Kantarjian, H.M., Estey, E.H., Plunkett, W., Keating, M.J., Walters, R.S., Iacoboni, S., McCredie, K.B., Freireich, E.J. Am. J. Med. (1986) [Pubmed]
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  7. Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium. Jin, M., Li, S., Moghrabi, W.N., Sun, H., Travis, G.H. Cell (2005) [Pubmed]
  8. Natural variation in light sensitivity of Arabidopsis. Maloof, J.N., Borevitz, J.O., Dabi, T., Lutes, J., Nehring, R.B., Redfern, J.L., Trainer, G.T., Wilson, J.M., Asami, T., Berry, C.C., Weigel, D., Chory, J. Nat. Genet. (2001) [Pubmed]
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  10. Treatment of acute migraine with subcutaneous sumatriptan. Cady, R.K., Wendt, J.K., Kirchner, J.R., Sargent, J.D., Rothrock, J.F., Skaggs, H. JAMA (1991) [Pubmed]
  11. Seasonal affective disorder and season-dependent abnormalities of melatonin suppression by light. Thompson, C., Stinson, D., Smith, A. Lancet (1990) [Pubmed]
  12. Isomerization and oxidation of vitamin a in cone-dominant retinas: a novel pathway for visual-pigment regeneration in daylight. Mata, N.L., Radu, R.A., Clemmons, R.C., Travis, G.H. Neuron (2002) [Pubmed]
  13. Disruption of the plastid ycf10 open reading frame affects uptake of inorganic carbon in the chloroplast of Chlamydomonas. Rolland, N., Dorne, A.J., Amoroso, G., Sültemeyer, D.F., Joyard, J., Rochaix, J.D. EMBO J. (1997) [Pubmed]
  14. Arabidopsis cytokinin receptor mutants reveal functions in shoot growth, leaf senescence, seed size, germination, root development, and cytokinin metabolism. Riefler, M., Novak, O., Strnad, M., Schmülling, T. Plant Cell (2006) [Pubmed]
  15. Synechocystis sp PCC 6803 strains lacking photosystem I and phycobilisome function. Shen, G., Boussiba, S., Vermaas, W.F. Plant Cell (1993) [Pubmed]
  16. Photoreception in Neurospora crassa: correlation of reduced light sensitivity with flavin deficiency. Paietta, J., Sargent, M.L. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  17. Regulation of cisplatin resistance and homologous recombinational repair by the TFIIH subunit XPD. Aloyz, R., Xu, Z.Y., Bello, V., Bergeron, J., Han, F.Y., Yan, Y., Malapetsa, A., Alaoui-Jamali, M.A., Duncan, A.M., Panasci, L. Cancer Res. (2002) [Pubmed]
  18. Targeted mutagenesis of the farnesylation site of Drosophila Ggammae disrupts membrane association of the G protein betagamma complex and affects the light sensitivity of the visual system. Schillo, S., Belusic, G., Hartmann, K., Franz, C., Kühl, B., Brenner-Weiss, G., Paulsen, R., Huber, A. J. Biol. Chem. (2004) [Pubmed]
  19. Frog rod outer segments with attached inner segment ellipsoids as an in vitro model for photoreceptors on the retina. Biernbaum, M.S., Bownds, M.D. J. Gen. Physiol. (1985) [Pubmed]
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  23. Chicken retinas contain a retinoid isomerase activity that catalyzes the direct conversion of all-trans-retinol to 11-cis-retinol. Mata, N.L., Ruiz, A., Radu, R.A., Bui, T.V., Travis, G.H. Biochemistry (2005) [Pubmed]
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  25. Keratosis follicularis spinulosa decalvans: report of a new pedigree. Herd, R.M., Benton, E.C. Br. J. Dermatol. (1996) [Pubmed]
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  29. Cytoskeleton participation in subcellular trafficking of signal transduction proteins in rod photoreceptor cells. McGinnis, J.F., Matsumoto, B., Whelan, J.P., Cao, W. J. Neurosci. Res. (2002) [Pubmed]
  30. Acid-sensitive mutants of Salmonella typhimurium identified through a dinitrophenol lethal screening strategy. Foster, J.W., Bearson, B. J. Bacteriol. (1994) [Pubmed]
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  32. Evolution of ocular manifestations in nephropathic cystinosis: a long-term study of a population treated with cysteamine. Dureau, P., Broyer, M., Dufier, J.L. Journal of pediatric ophthalmology and strabismus. (2003) [Pubmed]
  33. Levocabastine eye drops in the treatment of vernal conjunctivitis. Goes, F., Blockhuys, S., Janssens, M. Documenta ophthalmologica. Advances in ophthalmology. (1994) [Pubmed]
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