Gene Review:
AANAT - aralkylamine N-acetyltransferase
Homo sapiens
Synonyms:
AA-NAT, Aralkylamine N-acetyltransferase, DSPS, SNAT, Serotonin N-acetyltransferase, ...
- Serotoninergic and melatoninergic systems are fully expressed in human skin. Slominski, A., Pisarchik, A., Semak, I., Sweatman, T., Wortsman, J., Szczesniewski, A., Slugocki, G., McNulty, J., Kauser, S., Tobin, D.J., Jing, C., Johansson, O. FASEB J. (2002)
- Significant association of the arylalkylamine N-acetyltransferase ( AA-NAT) gene with delayed sleep phase syndrome. Hohjoh, H., Takasu, M., Shishikura, K., Takahashi, Y., Honda, Y., Tokunaga, K. Neurogenetics (2003)
- Characterization of the arylalkylamine N-acetyltransferase in Onchocerca volvulus. Aisien, S.O., Hellmund, C., Walter, R.D. Parasitol. Res. (1996)
- Design, synthesis and in vitro evaluation of novel benzo[b]thiophene derivatives as serotonin N-acetyltransferase (AANAT) inhibitors. Mesangeau, C., Yous, S., Chavatte, P., Ferry, G., Audinot, V., Boutin, J.A., Delagrange, P., Bennejean, C., Renard, P., Lesieur, D. Journal of enzyme inhibition and medicinal chemistry. (2003)
- Regulation of AA-NAT and HIOMT gene expression by butyrate and cyclic AMP in Y79 human retinoblastoma cells. Wiechmann, A.F., Burden, M.A. J. Pineal Res. (1999)
- Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation. Obsil, T., Ghirlando, R., Klein, D.C., Ganguly, S., Dyda, F. Cell (2001)
- Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis. Ganguly, S., Gastel, J.A., Weller, J.L., Schwartz, C., Jaffe, H., Namboodiri, M.A., Coon, S.L., Hickman, A.B., Rollag, M., Obsil, T., Beauverger, P., Ferry, G., Boutin, J.A., Klein, D.C. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Mechanism-based inhibition of the melatonin rhythm enzyme: pharmacologic exploitation of active site functional plasticity. Khalil, E.M., De Angelis, J., Ishii, M., Cole, P.A. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Melatonin and 5-methoxytryptophol (5-ML) in nervous and/or neurosensory structures of a gastropod mollusc (Helix aspersa maxima): synthesis and diurnal rhythms. Blanc, A., Vivien-Roels, B., Pévet, P., Attia, J., Buisson, B. Gen. Comp. Endocrinol. (2003)
- Identification of single-nucleotide polymorphisms (SNPs) of human N-acetyltransferase genes NAT1, NAT2, AANAT, ARD1 and L1CAM in the Japanese population. Sekine, A., Saito, S., Iida, A., Mitsunobu, Y., Higuchi, S., Harigae, S., Nakamura, Y. J. Hum. Genet. (2001)
- cAmp regulation of arylalkylamine N-acetyltransferase (AANAT, EC 2.3.1.87): a new cell line (1E7) provides evidence of intracellular AANAT activation. Coon, S.L., Weller, J.L., Korf, H.W., Namboodiri, M.A., Rollag, M., Klein, D.C. J. Biol. Chem. (2001)
- The human serotonin N-acetyltransferase (EC 2.3.1.87) gene (AANAT): structure, chromosomal localization, and tissue expression. Coon, S.L., Mazuruk, K., Bernard, M., Roseboom, P.H., Klein, D.C., Rodriguez, I.R. Genomics (1996)
- Substrate specificity and inhibition studies of human serotonin N-acetyltransferase. Ferry, G., Loynel, A., Kucharczyk, N., Bertin, S., Rodriguez, M., Delagrange, P., Galizzi, J.P., Jacoby, E., Volland, J.P., Lesieur, D., Renard, P., Canet, E., Fauchère, J.L., Boutin, J.A. J. Biol. Chem. (2000)
- X-ray crystallographic studies of serotonin N-acetyltransferase catalysis and inhibition. Wolf, E., De Angelis, J., Khalil, E.M., Cole, P.A., Burley, S.K. J. Mol. Biol. (2002)
- Melatonin synthesis enzymes in Macaca mulatta: focus on arylalkylamine N-acetyltransferase (EC 2.3.1.87). Coon, S.L., Del Olmo, E., Young, W.S., Klein, D.C. J. Clin. Endocrinol. Metab. (2002)
- Ovine arylalkylamine N-acetyltransferase in the pineal and pituitary glands: differences in function and regulation. Fleming, J.V., Barrett, P., Coon, S.L., Klein, D.C., Morgan, P.J. Endocrinology (1999)
- The melatonin receptor subtype MT1 is expressed in human gallbladder epithelia. Aust, S., Thalhammer, T., Humpeler, S., Jäger, W., Klimpfinger, M., Tucek, G., Obrist, P., Marktl, W., Penner, E., Ekmekcioglu, C. J. Pineal Res. (2004)
- Signal transduction and regulation of melatonin synthesis in bovine pinealocytes: impact of adrenergic, peptidergic and cholinergic stimuli. Schomerus, C., Laedtke, E., Olcese, J., Weller, J.L., Klein, D.C., Korf, H.W. Cell Tissue Res. (2002)
- Cellular stabilization of the melatonin rhythm enzyme induced by nonhydrolyzable phosphonate incorporation. Zheng, W., Zhang, Z., Ganguly, S., Weller, J.L., Klein, D.C., Cole, P.A. Nat. Struct. Biol. (2003)
- Mechanistic studies on the alkyltransferase activity of serotonin N-acetyltransferase. Zheng, W., Scheibner, K.A., Ho, A.K., Cole, P.A. Chem. Biol. (2001)
- Characterization and regulation of a CHO cell line stably expressing human serotonin N-acetyltransferase (EC 2.3.1.87). Ferry, G., Mozo, J., Ubeaud, C., Berger, S., Bertrand, M., Try, A., Beauverger, P., Mesangeau, C., Delagrange, P., Boutin, J.A. Cell. Mol. Life Sci. (2002)
- Norepinephrine activates store-operated Ca2+ entry coupled to large-conductance Ca2+-activated K+ channels in rat pinealocytes. Lee, S.Y., Choi, B.H., Hur, E.M., Lee, J.H., Lee, S.J., Lee, C.O., Kim, K.T. Am. J. Physiol., Cell Physiol. (2006)
- Isolation and mapping of a cosmid clone containing the human NAT2 gene. Franke, S., Klawitz, I., Schnakenberg, E., Rommel, B., Van de Ven, W., Bullerdiek, J., Schloot, W. Biochem. Biophys. Res. Commun. (1994)
- Expression of melatonin synthesis genes is controlled by a circadian clock in the pike pineal organ but not in the trout. Coon, S.L., Bégay, V., Falcón, J., Klein, D.C. Biol. Cell (1998)
- The ovine melatonin-related receptor: cloning and preliminary distribution and binding studies. Drew, J.E., Barrett, P., Williams, L.M., Conway, S., Morgan, P.J. J. Neuroendocrinol. (1998)
- Expression and cellular localization of melatonin-synthesizing enzymes in the rat lens. Itoh, M.T., Takahashi, N., Abe, M., Shimizu, K. J. Pineal Res. (2007)
- Thiolsubtilisin acts as an acetyltransferase in organic solvents. Tai, D.F., Liaw, W.C. FEBS Lett. (2002)
- Characterization of human melatonin synthesis using autoptic pineal tissue. Ackermann, K., Bux, R., Rüb, U., Korf, H.W., Kauert, G., Stehle, J.H. Endocrinology (2006)
- High-capacity screening of arylalkylamine N-acetyltransferase inhibitors using a high-performance liquid chromatography system. Ferry, G., Boutin, J.A. Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening. (2000)
- Duality of serotonin-N-acetyltransferase in the gilthead seabream (Sparus aurata): molecular cloning and characterization of recombinant enzymes. Zilberman-Peled, B., Benhar, I., Coon, S.L., Ron, B., Gothilf, Y. Gen. Comp. Endocrinol. (2004)