Disease relevance of Chronotherapy

• In anticipation of the development of clinical chronotherapy and in order to pick clinical test times for doxorubicin and cisplatin trials, two large studies were performed on rats bearing a transplanted plasmacytoma [1].
• Randomised multicentre trial of chronotherapy with oxaliplatin, fluorouracil, and folinic acid in metastatic colorectal cancer. International Organization for Cancer Chronotherapy [2].
• Experimental chronotherapy of mouse mammary adenocarcinoma MA13/C with docetaxel and doxorubicin as single agents and in combination [3].
• Phase I study of 5-fluorouracil and leucovorin by continuous infusion chronotherapy and pelvic radiotherapy in patients with locally advanced or recurrent rectal cancer [4].
• There are currently two antihypertensive agents, Verelan PM (verapamil HCl) and Covera HS (verapamil HCl), that provide chronotherapy for hypertension [5].

High impact information on Chronotherapy

• Time for chronotherapy? Clock genes dictate sensitivity to cyclophosphamide [6].
• Chronotherapy studies in allergic rhinitis suggest there are benefits to nighttime dosing of antiallergy medications [7].
• COX-2 expression was not able to explain either the chronotherapy or the chronotoxicity results obtained [8].
• In vitro circadian ANP secretion by gene transferring cells encapsulated in polycaprolactone tubes: gene chronotherapy [9].
• Chronotherapy of high-dose active vitamin D3 in haemodialysis patients with secondary hyperparathyroidsm: a repeated dosing study [10].

Chemical compound and disease context of Chronotherapy

• The chronotherapy of peptic ulcer disease achieved by the evening dosing of H 2-receptor antagonists and of asthma by the evening dosing of special drug delivery forms of theophylline and morning methylprednisolone administration has proven to be beneficial [11].
• Chronotherapy has been administered to 1500 patients with metastatic colorectal cancer using 5-fluorouracil and leucovorin with or without oxaliplatin [12].

Biological context of Chronotherapy

• A significant circadian rhythm disappeared or PEF amplitude decreased during theophylline chronotherapy [13].
• Theophylline chronotherapy of nocturnal asthma using bathyphase of circadian rhythm in peak expiratory flow rate [13].
• The treatments were based on chronobiology: resetting the daily life schedule, chronotherapy, regulation of the lighting environment, methylcobalamin, and/or melatonin [14].

Associations of Chronotherapy with chemical compounds

• CONCLUSION: The ORR achieved with intensified chronomodulated delivery of 5-FU/l-FA was nearly twice as high as that earlier obtained by our cooperative group using less intensive 5-FU/FA chronotherapy [15].
• Chronotherapy of trichlormethiazide in hypertensive patients [16].
• Once-daily evening administration of Uniphyl tablets: announcement of first available chronotherapy of nocturnal asthma [17].
• Thirteen patients with nocturnal asthma were evaluated before and during tulobuterol patch chronotherapy, applied once daily in the evening for 6 consecutive days [18].
• For each disorder, we present data addressing its pathophysiology and potential treatments, including the use of behavioral measures and chronotherapy, bright light treatment and pharmacological treatments such as melatonin [19].

Gene context of Chronotherapy

• These results provide a model for exploring optimal timing of chronotherapy with peptides, especially for treatment with telomerase inhibitors [20].
• Alteration of the circadian rhythm in peak expiratory flow of nocturnal asthma following nighttime transdermal beta2-adrenoceptor agonist tulobuterol chronotherapy [18].
• Toward a chronotherapy of ovarian cancer with taxol. Part I: Basic background [21].
• RESULTS: Pump, central venous system and disposable materials for a single chronotherapy cycle were Euro 193 or Euro 212 according to whether the pumps were bought or rented, compared to Euro 58 for the FOLFOX regimen [22].
• This goal can be pursued with M-CSF as well as Ca125 and UGP as possibly complementary chronobiologic markers in a chronotherapy trial with taxol in humans [23].

Analytical, diagnostic and therapeutic context of Chronotherapy

• While chronotherapy and light therapy are demanding and difficult treatments that usually lead to compliance problems, melatonin administration is a relatively simple and easy treatment option [24].
• Future Phase I/II studies need to define whether specific drug delivery systems or schedules are necessary for chronotherapy with 5-FU and FA in patients with colorectal carcinoma [25].
• DISCUSSION: The desynchronisation of plasma thiobarbituric acid reactive substances and the altered circadian characteristics of antioxidants observed in this study, may deserve further investigation for the early diagnosis, prognosis and for the efficacy of cancer chronotherapy [26].

References