Disease relevance of Halomonas

• In the present report, we cloned and expressed in Escherichia coli the betA gene from the moderate halophile Halomonas elongata which codes for a hypothetical choline dehydrogenase [1].
• Functional expression of the ectoine hydroxylase gene (thpD) from Streptomyces chrysomallus in Halomonas elongata [2].
• Characterization of biosynthetic enzymes for ectoine as a compatible solute in a moderately halophilic eubacterium, Halomonas elongata [3].

High impact information on Halomonas

• Isolation and characterization of salt-sensitive mutants of the moderate halophile Halomonas elongata and cloning of the ectoine synthesis genes [4].
• The moderate halophile Halomonas elongata Deustche Sammlung für Mikroorganismen 3043 accumulated ectoine, hydroxyectoine, glutamate, and glutamine in response to osmotic stress (3 M NaCl) [4].
• The halophilic bacterium Halomonas elongata synthesizes as its main compatible solute the aspartate derivative ectoine [5].
• We reported the preparation of a novel trehalose derivative based on enzymatic oxidation of trehalose by water-soluble glucose-3-dehydrogenase (G3DH) from marine bacterium Halomonas sp. alpha-15 cells [6].
• The biosynthetic pathway of ectoine from aspartic beta-semialdehyde (ASA), in Halomonas elongata, was elucidated by purification and characterization of each enzyme involved [3].

Chemical compound and disease context of Halomonas

• D. salina is not as closely related to other species belonging to the Halomonas-Deleya complex, but is more closely related to Halomonas elongata than to Deleya aquamarina, the type species of the genus Deleya [7].
• Osmoprotectants in Halomonas elongata: high-affinity betaine transport system and choline-betaine pathway [8].
• Cloning and expression of glucose 3-dehydrogenase from Halomonas sp. alpha-15 in Escherichia coli [9].
• epsABCJ genes are involved in the biosynthesis of the exopolysaccharide mauran produced by Halomonas maura [10].
• Carbon and energy fluxes during haloadaptation of Halomonas sp. EF11 growing on phenol [11].

Biological context of Halomonas

• Analysis of the complete 16S rRNA gene sequence revealed a high level of similarity with members of the genus Halomonas, sharing 98 % 16S rRNA gene sequence similarity with the type strains of Halomonas salina and Halomonas halophila [12].
• To overcome this, we established a transposon mutagenesis procedure for the ectoine-producing, halophilic bacterium Halomonas elongata [13].

Gene context of Halomonas

• Strain CHR63 is a salt-sensitive mutant of the moderately halophilic wild-type strain Halomonas elongata DSM 3043 that is affected in the ectoine synthase gene (ectC) [14].
• The alpha-amylase gene amyH of the moderate halophile Halomonas meridiana: cloning and molecular characterization [15].
• DNA-repair potential of Halomonas spp. from the Salt Plains Microbial Observatory of Oklahoma [16].
• Halomonas almeriensis sp. nov., a moderately halophilic, exopolysaccharide-producing bacterium from Cabo de Gata, Almería, south-east Spain [17].
• Purification, characterization, and gene sequencing of a catalase from an alkali- and halo-tolerant bacterium, Halomonas sp. SK1 [18].

References