Disease relevance of radC

• DNA repair in Mycobacterium tuberculosis. What have we learnt from the genome sequence [1]?
• DNA repair catalyzed by Escherichia coli DNA photolyase containing only reduced flavin: elimination of the enzyme's second chromophore by reduction with sodium borohydride [2].
• DNA repair in Bacillus subtilis. I. The presence of an inducible system [3].
• DNA-repair potential of Halomonas spp. from the Salt Plains Microbial Observatory of Oklahoma [4].
• DNA repair in Proteus mirabilis. VI. Plasmid (R46-) mediated recovery and UV mutagenesis [5].

High impact information on radC

• DNA repair alkyltransferases protect organisms against the cytotoxic, mutagenic, and carcinogenic effects of alkylating agents by transferring alkyl adducts from DNA to an active cysteine on the protein, thereby restoring the native DNA structure [6].
• DNA repair: bioinformatics helps reverse methylation damage [7].
• DNA repair: caretakers of the genome? [8].
• DNA repair synthesis dependent on the uvrA,B gene products in toluene-treated cells [9].
• DNA repair systems play a major role in maintaining the integrity of bacterial genomes [10].

Chemical compound and disease context of radC

• DNA repair systems were implicated in the hydrogen peroxide-dependent generation of 3'-OH DNA ends by the finding that the protein synthesis inhibitors chloramphenicol and diphtheria toxin blocked TUNEL labeling of E. coli and H. volcanii, respectively [11].
• DNA repair mechanisms affecting cytotoxicity by streptozotocin in E. coli [12].
• DNA repair and recovery in Escherichia coli after psoralen and angelicin photosensitization [13].

Biological context of radC

• DNA repair is required during development to ensure accuracy of DNA replication in the rapidly dividing embryonic cells and to maintain genomic integrity in the mature organism [14].
• DNA repair and mutagenesis in bacterial systems and their implications in oncology [15].
• DNA repair systems able to correct base pair mismatches within newly replicated DNA or within heteroduplex molecules produced during recombination are widespread among living organisms [16].
• Recent advances in DNA repair and recombination. A report of the DNA Repair Network meeting, held at City University, London on 19 December 1994 [17].
• DNA repair in microgravity: studies on bacteria and mammalian cells in the experiments REPAIR and KINETICS [18].

Anatomical context of radC

• DNA repair enzyme deficiency and in vitro complementation of the enzyme activity in cell-free extracts from ataxia telangiectasia fibroblasts [19].

Associations of radC with chemical compounds

• DNA repair methyltransferases (MTases) are stoichiometric acceptor molecules that are irreversibly inactivated in the course of removing a methyl group from O6-methylguanine (meG)-DNA or O4-methylthymine (meT)-DNA [20].
• DNA-repair processes sensitive to caffeine have been demonstrated in a number of cell systems and it has been shown to affect a wide range of other cellular processes [21].
• Effect of DNA Repair systems on antibacterial and mutagenic activity of an antitumor protein, neocarzinostatin [22].
• DNA repair synthesis was inhibited by p-chloromercuribenzoate and quinacrine [23].
• DNA repair in bacteria irradiated with X-rays and incubated with or without MB was examined by alkaline and neutral sucrose gradients [24].

References