Disease relevance of Afipia

• Genes encoding the mxaF of methanol dehydrogenase, the fdxA for Afipia ferredoxin, the msmA of methanesulfonate monooxygenase, and the 16S rRNA gene of Methylobacterium were detected in all samples tested [1].
• The culture conditions of Afipia felis, A. broomeae, A. clevelandensis and three unnamed Afipia genospecies were investigated on BCY agar supplemented with different substances known as growth factors of Legionella spp. and, furthermore, with sodium chloride and other salts [2].

High impact information on Afipia

• This is the first report of methanesulfonate-degrading bacteria from the Antarctic and of methylotrophy in Afipia, and the first description of any bacterium able to use both methanesulfonate and dimethylsulfone [3].
• Comparison of the in vitro efficacy of telithromycin (HMR 3647) and levofloxacin with 22 antibiotic compounds against Bosea and Afipia species [4].
• Killing kinetics of intracellular Afipia felis treated with amikacin [5].
• The quinone profiles of all "Afipia" strains were essentially identical, with ubiquinone 10 as the major component [6].
• (type strain 34632T = CIP 106344T = CCUG 43108T) and Afipia massiliensis sp. nov [7].

Chemical compound and disease context of Afipia

• Free-living Afipia strains occurring widely in the natural environment may be significant as methylotrophs, degrading C(1)-sulfur compounds, including the recalcitrant organosulfur compound methanesulfonate [3].
• A microagglutination test with heat-killed, safranin-stained whole-cell antigen for detecting antibodies to Afipia species has been developed [8].

Gene context of Afipia

• The frequency of sera positive for unnamed Afipia genospecies 1-3 was < 1% [8].
• The specificity of the immunopurified antigen was tested in EIA against hyperimmune rabbit sera and sera of rabbits inoculated with live B. henselae, B. quintana and Afipia felis [9].

References