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Chemical Compound Review

methylsulfone     methylsulfonylmethane

Synonyms: DMSO2, Lignisul MSM, CHEMBL25028, Opti MSM, CCRIS 2938, ...
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Disease relevance of methylsulfonylmethane


Psychiatry related information on methylsulfonylmethane


High impact information on methylsulfonylmethane


Chemical compound and disease context of methylsulfonylmethane


Biological context of methylsulfonylmethane


Anatomical context of methylsulfonylmethane


Associations of methylsulfonylmethane with other chemical compounds


Gene context of methylsulfonylmethane


Analytical, diagnostic and therapeutic context of methylsulfonylmethane

  • SDS-PAGE showed some membrane-associated polypeptides to be enhanced during growth with dimethylsulfone (54 kDa in H. sulfonivorans, 21-24 kDa, 54 kDa and 80 kDa in A. methylotrophus) [8].
  • Methylsulfonylmethane (MSM) is a widely available 'alternative' medicine [14].
  • When his condition did not improve with the use of a variety of topical and systemic treatments, a once-a-day, over-the-counter skin care regimen consisting of a surfactant-free cleanser followed by the application of moisturizer containing amino acids, vitamins, antioxidants, and methylsulfonylmethane was prescribed [15].


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  2. Dimethylsulfone as a growth substrate for novel methylotrophic species of Hyphomicrobium and Arthrobacter. Borodina, E., Kelly, D.P., Rainey, F.A., Ward-Rainey, N.L., Wood, A.P. Arch. Microbiol. (2000) [Pubmed]
  3. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Kim, L.S., Axelrod, L.J., Howard, P., Buratovich, N., Waters, R.F. Osteoarthr. Cartil. (2006) [Pubmed]
  4. Toxicity of methylsulfonylmethane in rats. Horváth, K., Noker, P.E., Somfai-Relle, S., Glávits, R., Financsek, I., Schauss, A.G. Food Chem. Toxicol. (2002) [Pubmed]
  5. Dimethyl sulfone (DMSO2) in the treatment of interstitial cystitis. Childs, S.J. Urol. Clin. North Am. (1994) [Pubmed]
  6. Polar solvents in the chemoprevention of dimethylbenzanthracene-induced rat mammary cancer. McCabe, D., O'Dwyer, P., Sickle-Santanello, B., Woltering, E., Abou-Issa, H., James, A. Archives of surgery (Chicago, Ill. : 1960) (1986) [Pubmed]
  7. Plasma concentrations and pharmacokinetics of dimethylsulfoxide and its metabolites in patients undergoing peripheral-blood stem-cell transplants. Egorin, M.J., Rosen, D.M., Sridhara, R., Sensenbrenner, L., Cottler-Fox, M. J. Clin. Oncol. (1998) [Pubmed]
  8. Enzymes of dimethylsulfone metabolism and the phylogenetic characterization of the facultative methylotrophs Arthrobacter sulfonivorans sp. nov., Arthrobacter methylotrophus sp. nov., and Hyphomicrobium sulfonivorans sp. nov. Borodina, E., Kelly, D.P., Schumann, P., Rainey, F.A., Ward-Rainey, N.L., Wood, A.P. Arch. Microbiol. (2002) [Pubmed]
  9. Detection of dimethyl sulfone in the human brain by in vivo proton magnetic resonance spectroscopy. Rose, S.E., Chalk, J.B., Galloway, G.J., Doddrell, D.M. Magnetic resonance imaging. (2000) [Pubmed]
  10. Pharmacokinetics and Distribution of [(35)S]Methylsulfonylmethane following Oral Administration to Rats. Magnuson, B.A., Appleton, J., Ames, G.B. J. Agric. Food Chem. (2007) [Pubmed]
  11. Effects of dimethyl sulfone (DMSO2) on early gametogenesis in Caenorhabditis elegans: ultrastructural aberrations and loss of synaptonemal complexes from pachytene nuclei. Goldstein, P., Magnano, L., Rojo, J. Reprod. Toxicol. (1992) [Pubmed]
  12. Methylsulfonylmethane (MSM) Ingestion Causes a Significant Resonance in Proton Magnetic Resonance Spectra of Brain and Cerebrospinal Fluid. Willemsen, M.A., Engelke, U.F., van der Graaf, M., Wevers, R.A. Neuropediatrics (2006) [Pubmed]
  13. Methylsulfonylmethane as a treatment for seasonal allergic rhinitis: additional data on pollen counts and symptom questionnaire. Barrager, E., Schauss, A.G. Journal of alternative and complementary medicine (New York, N.Y.) (2003) [Pubmed]
  14. Accumulation of methylsulfonylmethane in the human brain: identification by multinuclear magnetic resonance spectroscopy. Lin, A., Nguy, C.H., Shic, F., Ross, B.D. Toxicol. Lett. (2001) [Pubmed]
  15. Managing ichthyosis: a case study. Fleck, C.A. Ostomy/wound management. (2006) [Pubmed]
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