Disease relevance of methylsulfonylmethane

• In addition, the Arthrobacter sp. that was isolated grew on dimethylsulfone, and we believe that this is the first reported instance of a microorganism using dimethylsulfone as its primary carbon source [1].
• Dimethylsulfone as a growth substrate for novel methylotrophic species of Hyphomicrobium and Arthrobacter [2].
• Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial [3].
• Toxicity of methylsulfonylmethane in rats [4].
• Dimethyl sulfone (DMSO2) in the treatment of interstitial cystitis [5].

Psychiatry related information on methylsulfonylmethane

• Time to appearance (latency period) of both tumors and cancers were prolonged by NMF, DMSO, and 4% MSM [6].

High impact information on methylsulfonylmethane

• DMSO, DMSO2, and DMSH2 were assayed simultaneously by gas chromatography [7].
• Constitutive membrane-associated dimethylsulfone- and dimethylsulfoxide-reductases were found in Arthrobacter methylotrophus strain TGA and Hyphomicrobium sulfonivorans strain S1 [8].
• All strains contained rhodanese and sulfur oxygenase after growth with dimethylsulfone [8].
• We wish to report the detection of dimethyl sulfone (methylsulfonylmethane, C2H6O2S) in the brain of a normal 62-year-old male using in vivo proton magnetic resonance spectroscopy [9].
• Keywords: Methylsulfonylmethane; absorption; pharmacokinetics; distribution [10].

Chemical compound and disease context of methylsulfonylmethane

• Growth yields on dimethylsulfone and formaldehyde were consistent with the occurrence of the serine pathway in Hyphomicrobium strain S1 and the ribulose monophosphate cycle in Arthrobacter strain TGA, and with the proposed reductive pathway for dimethylsulfone degradation in both [2].

Biological context of methylsulfonylmethane

• Effects of dimethyl sulfone (DMSO2) on early gametogenesis in Caenorhabditis elegans: ultrastructural aberrations and loss of synaptonemal complexes from pachytene nuclei [11].

Anatomical context of methylsulfonylmethane

• The use of methylsulfonylmethane (MSM), available as an "over-the-counter" dietary supplement, led to the occurrence of an abnormal resonance at 3.15 ppm in the IN VIVO brain proton MR spectrum as well as the in vitro cerebrospinal fluid NMR study of a 4-year-old girl [12].

Associations of methylsulfonylmethane with other chemical compounds

• Methylsulfonylmethane (MSM) Ingestion Causes a Significant Resonance in Proton Magnetic Resonance Spectra of Brain and Cerebrospinal Fluid [12].

Gene context of methylsulfonylmethane

• Methylsulfonylmethane (MSM) is a popular dietary supplement used in a variety of conditions including pain, inflammation, allergies, arthritis, parasitic infections and the maintenance of normal keratin levels in hair, skin and nails [4].
• Methylsulfonylmethane as a treatment for seasonal allergic rhinitis: additional data on pollen counts and symptom questionnaire [13].

Analytical, diagnostic and therapeutic context of methylsulfonylmethane

• SDS-PAGE showed some membrane-associated polypeptides to be enhanced during growth with dimethylsulfone (54 kDa in H. sulfonivorans, 21-24 kDa, 54 kDa and 80 kDa in A. methylotrophus) [8].
• Methylsulfonylmethane (MSM) is a widely available 'alternative' medicine [14].
• When his condition did not improve with the use of a variety of topical and systemic treatments, a once-a-day, over-the-counter skin care regimen consisting of a surfactant-free cleanser followed by the application of moisturizer containing amino acids, vitamins, antioxidants, and methylsulfonylmethane was prescribed [15].

References