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MeSH Review

Dracunculus Nematode

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Disease relevance of Dracunculus Nematode

  • The Falcon assay screening test-enzyme-linked immunosorbent assay (FAST-ELISA) and the enzyme-linked immunoelectrotransfer blot (EITB) technique were used to test human sera with Dracunculus medinensis adult worm antigen in order to assess their potential value in the immunodiagnosis of dracunculiasis [1].

High impact information on Dracunculus Nematode


Chemical compound and disease context of Dracunculus Nematode


Biological context of Dracunculus Nematode

  • In March 1996, the Volta rural water supply and sanitation (VRWSS) project commissioned a guinea worm prevalence and knowledge, attitude and practice (KAP) study to collect baseline prevalence data [5].

Associations of Dracunculus Nematode with chemical compounds


Analytical, diagnostic and therapeutic context of Dracunculus Nematode

  • The enzymes linked immunosorbent assay (ELISA) was used to test human sera from patients with prepatent and patent Dracunculus medinensis infection with adult worm antigen to asses its potential value in the Immunodiagnosis of early asymptomatic guinea worm infection [8].
  • Sera from persons living in the Guinea worm endemic area reacted extensively with Guinea worm antigen in both tests, and large numbers of bands were produced in the Western blots (up to 35 identified for some sera) [9].


  1. Immunodiagnosis of dracunculiasis by Falcon assay screening test-enzyme-linked immunosorbent assay (FAST-ELISA) and by enzyme-linked immunoelectrotransfer blot (EITB) technique. Fagbemi, B.O., Hillyer, G.V. Am. J. Trop. Med. Hyg. (1990) [Pubmed]
  2. The effect of antibiotic- and hydrocortisone-containing ointments in preventing secondary infections in guinea worm disease. Magnussen, P., Yakubu, A., Bloch, P. Am. J. Trop. Med. Hyg. (1994) [Pubmed]
  3. Failure of thiabendazole and metronidazole in the treatment and suppression of guinea worm disease. Belcher, D.W., Wunapa, F.K., Ward, W.B. Am. J. Trop. Med. Hyg. (1975) [Pubmed]
  4. Disinfectants/antiseptics in the management of guinea worm ulcers in the rural areas. Ogunniyi, T.A., Oni, P.O., Juba, A., Asaolu, S.O., Kolawole, D.O. Acta Trop. (2000) [Pubmed]
  5. Guinea worm disease--a chance for successful eradication in the Volta Region, Ghana. Diamenu, S.K., Nyaku, A.A. Social science & medicine (1982) (1998) [Pubmed]
  6. Notions and treatment of guinea worm in northern Ghana. Bierlich, B. Social science & medicine (1982) (1995) [Pubmed]
  7. Preliminary report on the therapeutic effect of mebendazole in guinea worm infection. Shafei, A.Z. The Journal of tropical medicine and hygiene. (1976) [Pubmed]
  8. Immunodiagnosis of early dracunculiasis. Bapna, S., Renapurkar, D.M. The Journal of communicable diseases. (1996) [Pubmed]
  9. The antibody response to Dracunculus medinensis in an endemic human population of northern Ghana. Bloch, P., Simonsen, P.E., Vennervald, B.J. J. Helminthol. (1993) [Pubmed]
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