Disease relevance of Dracunculus Nematode

• The Falcon assay screening test-enzyme-linked immunosorbent assay (FAST-ELISA) and the enzyme-linked immunoelectrotransfer blot (EITB) technique were used to test human sera with Dracunculus medinensis adult worm antigen in order to assess their potential value in the immunodiagnosis of dracunculiasis [1].

High impact information on Dracunculus Nematode

• The effect of antibiotic- and hydrocortisone-containing ointments in preventing secondary infections in guinea worm disease [2].
• Failure of thiabendazole and metronidazole in the treatment and suppression of guinea worm disease [3].
• Guinea worm disease is endemic in West Africa. In 1973 a field drug trial was conducted to compare effectiveness, cost, and side-effects of thiabendazole and metronidazole in treating active guinea worm disease and preventing latent worms from emerging [3].
• The effectiveness of trichlorophenol (TCP), chlorhexidine gluconate plus cetrimide (Savlon) and Izal in inhibiting the growth of bacterial isolates from guinea worm ulcers was investigated [4].
• Guinea worm disease--a chance for successful eradication in the Volta Region, Ghana [5].

Chemical compound and disease context of Dracunculus Nematode

• Dracunculiasis, infection with Dracunculus medinensis or guinea worm, is widespread in the Northern Region of Ghana, where rural people drink from unprotected water sources such as ponds and small-scale dams [6].

Biological context of Dracunculus Nematode

• In March 1996, the Volta rural water supply and sanitation (VRWSS) project commissioned a guinea worm prevalence and knowledge, attitude and practice (KAP) study to collect baseline prevalence data [5].

Associations of Dracunculus Nematode with chemical compounds

• Preliminary report on the therapeutic effect of mebendazole in guinea worm infection [7].

Analytical, diagnostic and therapeutic context of Dracunculus Nematode

• The enzymes linked immunosorbent assay (ELISA) was used to test human sera from patients with prepatent and patent Dracunculus medinensis infection with adult worm antigen to asses its potential value in the Immunodiagnosis of early asymptomatic guinea worm infection [8].
• Sera from persons living in the Guinea worm endemic area reacted extensively with Guinea worm antigen in both tests, and large numbers of bands were produced in the Western blots (up to 35 identified for some sera) [9].

References