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MeSH Review:

Isodon

Hwang, B.Y. et al., Xiang, W. et al., Han, Q.B. et al., Hou, A.J. et al., Li, B.L., et al.

Jeong, Chang, Kim, Kim, Kinghorn, Pezzuto,

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High impact information on Isodon

A novel cytotoxic oxetane ent-kauranoid from Isodon japonicus [1].
Effusanin A (2), effusanin B (3), effusanin E (4), lasiokaurin (5) and oridonin (6) were found as known constituents of the genus Isodon with C-20/C-7 epoxy function [2].
Two new C-20-oxygenated ent-kaurene diterpenoids, taibaijaponicains C and D, together with five known compounds, were isolated from the ethanol extract of the leaves and branches of Isodon japonica (Burm. f.) Hara [3].
Kaurane diterpenes from Isodon japonicus inhibit nitric oxide and prostaglandin E2 production and NF-kappaB activation in LPS-stimulated macrophage RAW264.7 cells [4].
A methanolic extract of the whole plant of Isodon japonicus (Labiatae) showed potent inhibition on the LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production in RAW264.7 cells [4].

Associations of Isodon with chemical compounds

These results suggest that kaurane diterpenes could exert their inhibitory effects on the production of NO and PGE2 through the suppression of NF-kappaB activation, and be partially responsible for the anti-inflammatory activities of the genus Isodon [4].
Three new ent-kaurene diterpenoids, oreskaurins A-C (1-3), together with ten known ent-kaurene diterpenoids, enmenin monoacetate (4), effusanin E (5), adenolin B (6), maoecrystal G (7), enmelol (8), trichokaurin (9), sodoponin (10), trichorabdal A (11), nodosin (12), enmein (13), and a flavonoid, vitexin (14), were isolated from Isodon oresbius [5].
Five new ent-kaurane diterpenoids, ludongnins F-J (1-5), along with 10 known compounds, guidongnins A-C (6-8), angustifolin (9), 6-epiangustifolin (10), sculponeatin J (11), gardenin D, 5,3',4'-trihydroxy-6,7,8-trimethoxyflavone, pedalitin, and quercetin, were isolated from the leaves of Isodon rubescens var. lushiensis [6].
Four new diterpenoids, melissoidesin E (1), F (2), G (4) and H (5), together with one known diterpenoid and two lignan glycosides, were isolated from aerial parts of Isodon melissoides [7].
A new ent-kaurane diterpenoid, phyllostachysin C (1), together with five known compounds, sculponeatins B and C, nodosin, ursolic acid and 2 alpha-hydroxyursolic acid, were isolated from the leaves of Isodon phyllostachys [8].

Gene context of Isodon

Aromatase inhibitors from Isodon excisus var. coreanus [9].

References

A novel cytotoxic oxetane ent-kauranoid from Isodon japonicus. Han, Q., Zhang, J., Lu, Y., Wu, Y., Zheng, Q., Sun, H. Planta Med. (2004) [Pubmed]
A new diepoxy-ent-kauranoid, rugosinin, from Isodon rugosus. Abbaskhan, A., Choudhary, M.I., Tsuda, Y., Parvez, M., Atta-ur-Rahman, n.u.l.l., Shaheen, F., Parween, Z., Tareen, R.B., Zaidi, M.A. Planta Med. (2003) [Pubmed]
Taibaijaponicains C and D: two new diterpenoids from Isodon japonica. Li, B.L. Planta Med. (2002) [Pubmed]
Kaurane diterpenes from Isodon japonicus inhibit nitric oxide and prostaglandin E2 production and NF-kappaB activation in LPS-stimulated macrophage RAW264.7 cells. Hwang, B.Y., Lee, J.H., Koo, T.H., Kim, H.S., Hong, Y.S., Ro, J.S., Lee, K.S., Lee, J.J. Planta Med. (2001) [Pubmed]
ent-Kaurene diterpenoids from Isodon oresbius. Xiang, W., Li, R.T., Wang, Z.Y., Li, S.H., Zhao, Q.S., Zhang, H.J., Sun, H.D. Phytochemistry (2004) [Pubmed]
Cytotoxic constituents of Isodon rubescens var. lushiensis. Han, Q.B., Zhao, A.H., Zhang, J.X., Lu, Y., Zhang, L.L., Zheng, Q.T., Sun, H.D. J. Nat. Prod. (2003) [Pubmed]
Chemical constituents of Isodon melissoides. Zhao, Q.S., Jiang, B., Lin, Z.W., Sun, H.D. Journal of Asian natural products research. (1999) [Pubmed]
A new ent-kaurane diterpenoid from Isodon phyllostachys. Hou, A.J., Yang, H., Jiang, B., Zhao, Q.S., Lin, Z.W., Sun, H.D. Fitoterapia (2000) [Pubmed]
Aromatase inhibitors from Isodon excisus var. coreanus. Jeong, H.J., Chang, L.C., Kim, H.K., Kim, I.H., Kinghorn, A.D., Pezzuto, J.M. Arch. Pharm. Res. (2000) [Pubmed]

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