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MeSH Review:

Gestational Trophoblastic Neoplasms

Collins, R.H. et al., Berkowitz, R.S. et al., Lei, Z.M. et al., Berkowitz, R.S. et al., Maymon, R. et al., et al.

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Disease relevance of Gestational Trophoblastic Neoplasms

A patient with gestational trophoblastic neoplasm failed treatment with several standard chemotherapy regimens and had progressive disease with development of lung and brain metastases and a rising HCG level [1].
The comparative systemic toxicity of methotrexate (MTX) with citrovorum factor rescue (CF), MTX alone and actinomycin-D (Act-D) in the treatment of gestational trophoblastic neoplasms (GTN) was evaluated in the present study [2].

High impact information on Gestational Trophoblastic Neoplasms

Human gestational trophoblastic neoplasms overexpress hCG/LH receptors [3].
In summary, this is the first study to our knowledge demonstrating the expression of hCG/hLH receptor gene in gestational trophoblastic neoplasms [4].
The expression of human chorionic gonadotropin/human luteinizing hormone receptors in human gestational trophoblastic neoplasms [4].
Further studies, including serum PLF among other categories of gestational trophoblastic neoplasms, are recommended before this data can be integrated into routine clinical work [5].
Successful treatment of refractory gestational trophoblastic neoplasm with high-dose etoposide and cyclophosphamide [1].

Chemical compound and disease context of Gestational Trophoblastic Neoplasms

Fifteen patients with nonmetastatic gestational trophoblastic neoplasms were treated primarily with methotrexate and citrovorum factor [6].
Reevaluation of 5-fluorouracil as a single therapeutic agent for gestational trophoblastic neoplasms [7].
Two patients with resistant gestational trophoblastic neoplasms were treated with vinblastine, bleomycin, and cisplatin (Einhorn regimen) [8].

Gene context of Gestational Trophoblastic Neoplasms

Whereas, in gestational trophoblastic neoplasm (GTD) only few markers have been studied, and some correlated with progression [9].

Analytical, diagnostic and therapeutic context of Gestational Trophoblastic Neoplasms

Fifty-one patients with nonmetastatic gestational trophoblastic neoplasms (NMGTN) were treated with either 4 or 6 mg/kg methotrexate (MTX) and citrovorum factor (CF) rescue to determine if the higher dosage could reduce the number of courses of chemotherapy required to achieve remission [10].

References

Successful treatment of refractory gestational trophoblastic neoplasm with high-dose etoposide and cyclophosphamide. Collins, R.H., White, C.S., Stringer, C.A., Fay, J.W. Gynecol. Oncol. (1991) [Pubmed]
Methotrexate with citrovorum factor rescue: reduced chemotherapy toxicity in the management of gestational trophoblastic neoplasms. Berkowitz, R.S., Goldstein, D.P., Jones, M.A., Marean, A.R., Bernstein, M.R. Cancer (1980) [Pubmed]
Lack of self-regulation of human chorionic gonadotropin biosynthesis in human choriocarcinoma cells. Licht, P., Cao, H., Zuo, J., Lei, Z.M., Rao, V., Merz, W.E., Day, T.G. J. Clin. Endocrinol. Metab. (1994) [Pubmed]
The expression of human chorionic gonadotropin/human luteinizing hormone receptors in human gestational trophoblastic neoplasms. Lei, Z.M., Rao, C.V., Ackerman, D.M., Day, T.G. J. Clin. Endocrinol. Metab. (1992) [Pubmed]
Placental isoferritin levels during first trimester of normal and complete molar gestations. Maymon, R., Weinraub, Z., Bukovsky, I., Moroz, C. Placenta (1995) [Pubmed]
Methotrexate with citrovorum factor rescue for nonmetastatic gestational trophoblastic neoplasms. Goldstein, D.P., Goldstein, P.R., Bottomley, P., Osathanondh, R., Marean, A.R. Obstetrics and gynecology. (1976) [Pubmed]
Reevaluation of 5-fluorouracil as a single therapeutic agent for gestational trophoblastic neoplasms. Sung, H.C., Wu, P.C., Yang, H.Y. Am. J. Obstet. Gynecol. (1984) [Pubmed]
Resistant gestational choriocarcinoma: successful treatment with vinblastine, bleomycin, and cisplatin (VBP). Hainsworth, J.D., Burnett, L.S., Jones, H.W., Greco, F.A. Cancer treatment reports. (1983) [Pubmed]
Angiogenesis in gynecological oncology-mechanism of tumor progression and therapeutic targets. Rasila, K.K., Burger, R.A., Smith, H., Lee, F.C., Verschraegen, C. Int. J. Gynecol. Cancer (2005) [Pubmed]
Methotrexate with citrovorum factor rescue for nonmetastatic gestational trophoblastic neoplasms. Berkowitz, R.S., Goldstein, D.P. Obstetrics and gynecology. (1979) [Pubmed]

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