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MeSH Review:

Tribulus

Achenbach, H. et al., Li, J.X. et al., Brown, G.A. et al., Bourke, C.A., Adimoelja, A., et al.

Neychev, Mitev, Kohut, Thompson, Campbell, Brown, Vukovich, Jackson, King,

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High impact information on Tribulus

Three new steroidal saponins 1-3, together with five known steroidal saponins, L-mannitol and an inorganic salt were isolated from Tribulus terrestris L [1].
Tribulusamides A (1) and B (2), new lignanamides embracing two cinnamic amide parts joined in a cis configuration, were isolated from the fruits of Tribulus terrestris, together with four known compounds, N-trans-feruloyltyramine (3), terrestriamide (4), N-trans-coumaroyltyramine (5), and beta-sitosterol [2].
Cytotoxic furostanol saponins and a megastigmane glucoside from tribulus parvispinus [3].
The supplement contained a total daily dose of 150 mg DHEA, 300 mg androstenedione, 750 mg Tribulus terrestris, 625 mg chrysin, 300 mg indole-3-carbinol and 540 mg saw palmetto [4].
Subjects were randomly assigned to consume DION (300 mg androstenedione, 150 mg dehydroepiandrosterone, 540 mg saw palmetto, 300 mg indole-3-carbinol, 625 mg chrysin, and 750 mg Tribulus terrestris per day; n = 28) or placebo (n = 27) for 28 days [5].

Anatomical context of Tribulus

OBJECTIVE: To observe the clinical signs of sheep affected by Tribulus terrestris motor neuron disease, to ascertain their response to striatal dopamine reducing drugs, and to examine their brains and spinal cords for microscopic changes [6].

Associations of Tribulus with chemical compounds

Cardioactive steroid saponins and other constituents from the aerial parts of Tribulus cistoides [7].
Protodioscin is a phytochemical agent derived from Tribulus terrestris L plant, which has been clinically proven to improve sexual desire and enhance erection via the conversion of protodioscine to DHEA (De-Hydro-Epi-Androsterone) [8].
Cholestane- and pregnane-type glycosides from the roots of Tribulus cistoides [9].
From the petrol extract of the aerial parts of Tribulus cistoides three steroid sapogenins and two N-acyltyramines were isolated, whereas the methanolic extract gave nine steroid saponins, among them the cardioactive cistocardin, saponin-3, saponin-4 and saponin-7 [7].
OBJECTIVE: The aim of the current study is to investigate the influence of Tribulus terrestris extract on androgen metabolism in young males [10].

References

Three new saponins from Tribulus terrestris. Xu, Y.X., Chen, H.S., Liang, H.Q., Gu, Z.B., Liu, W.Y., Leung, W.N., Li, T.J. Planta Med. (2000) [Pubmed]
Tribulusamide A and B, new hepatoprotective lignanamides from the fruits of Tribulus terrestris: indications of cytoprotective activity in murine hepatocyte culture. Li, J.X., Shi, Q., Xiong, Q.B., Prasain, J.K., Tezuka, Y., Hareyama, T., Wang, Z.T., Tanaka, K., Namba, T., Kadota, S. Planta Med. (1998) [Pubmed]
Cytotoxic furostanol saponins and a megastigmane glucoside from tribulus parvispinus. Perrone, A., Plaza, A., Bloise, E., Nigro, P., Hamed, A.I., Belisario, M.A., Pizza, C., Piacente, S. J. Nat. Prod. (2005) [Pubmed]
Ingestion of a dietary supplement containing dehydroepiandrosterone (DHEA) and androstenedione has minimal effect on immune function in middle-aged men. Kohut, M.L., Thompson, J.R., Campbell, J., Brown, G.A., Vukovich, M.D., Jackson, D.A., King, D.S. Journal of the American College of Nutrition. (2003) [Pubmed]
Effects of androstenedione-herbal supplementation on serum sex hormone concentrations in 30- to 59-year-old men. Brown, G.A., Vukovich, M.D., Martini, E.R., Kohut, M.L., Franke, W.D., Jackson, D.A., King, D.S. International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition. (2001) [Pubmed]
Abnormal turning behaviour, GABAergic inhibition and the degeneration of astrocytes in ovine Tribulus terrestris motor neuron disease. Bourke, C.A. Aust. Vet. J. (2006) [Pubmed]
Cardioactive steroid saponins and other constituents from the aerial parts of Tribulus cistoides. Achenbach, H., Hübner, H., Brandt, W., Reiter, M. Phytochemistry (1994) [Pubmed]
Phytochemicals and the breakthrough of traditional herbs in the management of sexual dysfunctions. Adimoelja, A. Int. J. Androl. (2000) [Pubmed]
Cholestane- and pregnane-type glycosides from the roots of Tribulus cistoides. Achenbach, H., Hübner, H., Reiter, M. Phytochemistry (1996) [Pubmed]
The aphrodisiac herb Tribulus terrestris does not influence the androgen production in young men. Neychev, V.K., Mitev, V.I. Journal of ethnopharmacology. (2005) [Pubmed]

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