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High impact information on Droseraceae


Associations of Droseraceae with chemical compounds

  • Aqueous leaf extracts from Dionaea muscipula contain quinones such as the naphthoquinone plumbagin that couple to different NADH-dependent diaphorases, producing superoxide and hydrogen peroxide upon autoxidation [6].
  • The dynamics of the "Venus flytrap" mechanism has been studied, suggesting that the molecular dipole moments play a key role in GABA binding and receptor activation [7].
  • An unusual receptor tyrosine kinase of Schistosoma mansoni contains a Venus Flytrap module [8].
  • Of the other naphthoquinones typical for the family Droseraceae only hydroplumbagin glucoside could be detected, whereas the presence of 7-methyljuglone and rossoliside (= 7-methylhydrojuglone glucoside) was excluded [9].
  • Their location in a modeled three-dimensional structure suggests that ifenprodil binds in the cleft of the LIVBP-like domain of NR2B by a mechanism (Venus-flytrap) resembling that of the binding of Zn on the LIVBP-like domain of NR2A [10].

Gene context of Droseraceae

  • Like any other family 3 G-protein-coupled receptors, GB1 and GB2 are composed of a Venus Flytrap module (VFTM) that usually contains the agonist-binding site and a heptahelical domain [11].
  • The core of the ligand-binding domain is homologous to prokaryotic periplasmic binding proteins (PBP), whose binding mechanism involves a dramatic cleft closure: the "Venus flytrap". Several models of GluR function have proposed that a similar cleft closure is induced by agonist binding [12].
  • An anticarcinoembryonic antigen (CEA) monoclonal antibody, T84.66, has been conjugated to a metallocarborane complex (Venus flytrap cluster, VFC) containing 57Co [13].


  1. Different functional roles of T1R subunits in the heteromeric taste receptors. Xu, H., Staszewski, L., Tang, H., Adler, E., Zoller, M., Li, X. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors. Goudet, C., Gaven, F., Kniazeff, J., Vol, C., Liu, J., Cohen-Gonsaud, M., Acher, F., Prézeau, L., Pin, J.P. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. Mutagenesis and modeling of the GABAB receptor extracellular domain support a venus flytrap mechanism for ligand binding. Galvez, T., Parmentier, M.L., Joly, C., Malitschek, B., Kaupmann, K., Kuhn, R., Bittiger, H., Froestl, W., Bettler, B., Pin, J.P. J. Biol. Chem. (1999) [Pubmed]
  4. A venus flytrap mechanism for activation and desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors. Mano, I., Lamed, Y., Teichberg, V.I. J. Biol. Chem. (1996) [Pubmed]
  5. Naturally occurring mutations of the extracellular Ca2+-sensing receptor: implications for its structure and function. Hu, J., Spiegel, A.M. Trends Endocrinol. Metab. (2003) [Pubmed]
  6. Oxidative protein modification as predigestive mechanism of the carnivorous plant Dionaea muscipula: an hypothesis based on in vitro experiments. Galek, H., Osswald, W.F., Elstner, E.F. Free Radic. Biol. Med. (1990) [Pubmed]
  7. Molecular modeling of the GABA/GABA(B) receptor complex. Bernard, P., Guedin, D., Hibert, M. J. Med. Chem. (2001) [Pubmed]
  8. An unusual receptor tyrosine kinase of Schistosoma mansoni contains a Venus Flytrap module. Vicogne, J., Pin, J.P., Lardans, V., Capron, M., Noël, C., Dissous, C. Mol. Biochem. Parasitol. (2003) [Pubmed]
  9. Naphthoquinone glucosides of Drosera gigantea from in vitro cultures. Budzianowski, J. Planta Med. (2000) [Pubmed]
  10. Mapping the binding site of the neuroprotectant ifenprodil on NMDA receptors. Perin-Dureau, F., Rachline, J., Neyton, J., Paoletti, P. J. Neurosci. (2002) [Pubmed]
  11. No ligand binding in the GB2 subunit of the GABA(B) receptor is required for activation and allosteric interaction between the subunits. Kniazeff, J., Galvez, T., Labesse, G., Pin, J.P. J. Neurosci. (2002) [Pubmed]
  12. A molecular envelope of the ligand-binding domain of a glutamate receptor in the presence and absence of agonist. Abele, R., Svergun, D., Keinänen, K., Koch, M.H., Madden, D.R. Biochemistry (1999) [Pubmed]
  13. Pharmacokinetics of an anti-carcinoembryonic antigen monoclonal antibody conjugated to a bifunctional transition metal carborane complex (venus flytrap cluster) in tumor-bearing mice. Beatty, B.G., Paxton, R.J., Hawthorne, M.F., Williams, L.E., Rickard-Dickson, K.J., Do, T., Shively, J.E., Beatty, J.D. J. Nucl. Med. (1993) [Pubmed]
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