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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Neoplasms, Germ Cell and Embryonal

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Disease relevance of Neoplasms, Germ Cell and Embryonal


High impact information on Neoplasms, Germ Cell and Embryonal

  • We have examined the imprinting of the insulin-like growth factor II gene (IGF2) in ten normal kidney samples from children with renal embryonal neoplasms [5].
  • These results establish that aberrant Id2 activity directs initiation and progression of embryonal cancer [6].
  • Our study demonstrates that laminin potentiates cisplatin-induced apoptosis in NCCIT, a testicular tumor germ cell line [7].
  • Assessment of proliferation rates using MIB-1 antibody in clinical Stage A nonseminomatous germ-cell-tumor patients may prove helpful in predicting metastatic status.(ABSTRACT TRUNCATED AT 250 WORDS)[8]
  • The heritable changes in the expression, and imprinting status of the Igf-2 and H19 genes observed in the F x W cells closely resembles events described in human embryonal cancers and cancer-predisposing syndromes [9].

Chemical compound and disease context of Neoplasms, Germ Cell and Embryonal


Biological context of Neoplasms, Germ Cell and Embryonal


Gene context of Neoplasms, Germ Cell and Embryonal

  • We conclude that wild-type WT1 can induce apoptosis in embryonal cancer cells, presumably through the withdrawal of required growth factor survival signals, and that EGFR is a physiological target gene for WT1 [12].
  • Wilms tumor (WT) is a malignant embryonal neoplasm of the kidney and is one of the most common solid tumors of childhood, occurring at an estimated frequency of 1 in 8000 to 10,000 births [13].
  • The risk of an SMN was approximately 11% among the 64 NF1 registrants with primary malignancies in the CHOP registry, but was 75% (6 of 8) among patients treated for a pediatric embryonal cancer [14].


  1. Children with idiopathic hemihypertrophy and beckwith-wiedemann syndrome have different constitutional epigenotypes associated with wilms tumor. Niemitz, E.L., Feinberg, A.P., Brandenburg, S.A., Grundy, P.E., DeBaun, M.R. Am. J. Hum. Genet. (2005) [Pubmed]
  2. Epigenetic alterations of H19 and LIT1 distinguish patients with Beckwith-Wiedemann syndrome with cancer and birth defects. DeBaun, M.R., Niemitz, E.L., McNeil, D.E., Brandenburg, S.A., Lee, M.P., Feinberg, A.P. Am. J. Hum. Genet. (2002) [Pubmed]
  3. Loss of imprinting of insulin-like growth factor-II in Wilms' tumor commonly involves altered methylation but not mutations of CTCF or its binding site. Cui, H., Niemitz, E.L., Ravenel, J.D., Onyango, P., Brandenburg, S.A., Lobanenkov, V.V., Feinberg, A.P. Cancer Res. (2001) [Pubmed]
  4. c-myc overexpression causes anaplasia in medulloblastoma. Stearns, D., Chaudhry, A., Abel, T.W., Burger, P.C., Dang, C.V., Eberhart, C.G. Cancer Res. (2006) [Pubmed]
  5. Constitutional relaxation of insulin-like growth factor II gene imprinting associated with Wilms' tumour and gigantism. Ogawa, O., Becroft, D.M., Morison, I.M., Eccles, M.R., Skeen, J.E., Mauger, D.C., Reeve, A.E. Nat. Genet. (1993) [Pubmed]
  6. Id2 mediates tumor initiation, proliferation, and angiogenesis in Rb mutant mice. Lasorella, A., Rothschild, G., Yokota, Y., Russell, R.G., Iavarone, A. Mol. Cell. Biol. (2005) [Pubmed]
  7. Alpha6 integrin subunit mediates laminin enhancement of cisplatin-induced apoptosis in testicular tumor germ cells. Andjilani, M., Droz, J.P., Benahmed, M., Tabone, E. Int. J. Cancer (2005) [Pubmed]
  8. Prognostic significance of immunohistochemical proliferation markers (Ki-67/MIB-1 and proliferation-associated nuclear antigen), p53 protein accumulation, and neovascularization in clinical stage A nonseminomatous testicular germ cell tumors. Albers, P., Orazi, A., Ulbright, T.M., Miller, G.A., Haidar, J.H., Donohue, J.P., Foster, R.S. Mod. Pathol. (1995) [Pubmed]
  9. Relaxation of insulin-like growth factor-2 imprinting in rat cultured cells. Ungaro, P., Casola, S., Vernucci, M., Pedone, P.V., Bruni, C.B., Riccio, A. Mol. Cell. Endocrinol. (1997) [Pubmed]
  10. Retinoic acid causes a decline in TGF-alpha expression, cloning efficiency, and tumorigenicity in a human embryonal cancer cell line. Dmitrovsky, E., Moy, D., Miller, W.H., Li, A., Masui, H. Oncogene Res. (1990) [Pubmed]
  11. Nephroblastic neoplasms. Khoury, J.D. Clin. Lab. Med. (2005) [Pubmed]
  12. Functional properties of WT1. Haber, D.A., Englert, C., Maheswaran, S. Med. Pediatr. Oncol. (1996) [Pubmed]
  13. Synchronous wilms tumor and fibrolamellar hepatocellular carcinoma: report of a case. Maitra, A., Ramnani, D.M., Margraf, L.R., Gazdar, A.F. Pediatr. Dev. Pathol. (2000) [Pubmed]
  14. Monosomy 7 myelodysplastic syndrome and other second malignant neoplasms in children with neurofibromatosis type 1. Maris, J.M., Wiersma, S.R., Mahgoub, N., Thompson, P., Geyer, R.J., Hurwitz, C.G., Lange, B.J., Shannon, K.M. Cancer (1997) [Pubmed]
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