Gene Review:
Id2 - inhibitor of DNA binding 2
Mus musculus
Synonyms:
AI255428, C78922, DNA-binding protein inhibitor ID-2, Id-2, Idb2, ...
- Role of Id-2 in the maintenance of a differentiated and noninvasive phenotype in breast cancer cells. Itahana, Y., Singh, J., Sumida, T., Coppe, J.P., Parrinello, S., Bennington, J.L., Desprez, P.Y. Cancer Res. (2003)
- Id-2 regulates critical aspects of human cytotrophoblast differentiation, invasion and migration. Janatpour, M.J., McMaster, M.T., Genbacev, O., Zhou, Y., Dong, J., Cross, J.C., Israel, M.A., Fisher, S.J. Development (2000)
- Essential role of Id2 in negative regulation of IgE class switching. Sugai, M., Gonda, H., Kusunoki, T., Katakai, T., Yokota, Y., Shimizu, A. Nat. Immunol. (2003)
- E protein function in lymphocyte development. Quong, M.W., Romanow, W.J., Murre, C. Annu. Rev. Immunol. (2002)
- Constitutive expression of the Id1 gene impairs mouse B cell development. Sun, X.H. Cell (1994)
- Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2. Yokota, Y., Mansouri, A., Mori, S., Sugawara, S., Adachi, S., Nishikawa, S., Gruss, P. Nature (1999)
- Early neocortical regionalization in the absence of thalamic innervation. Miyashita-Lin, E.M., Hevner, R., Wassarman, K.M., Martinez, S., Rubenstein, J.L. Science (1999)
- Inhibition of muscle-specific gene expression by Id3: requirement of the C-terminal region of the protein for stable expression and function. Chen, B., Han, B.H., Sun, X.H., Lim, R.W. Nucleic Acids Res. (1997)
- Differential biological activities of mammalian Id proteins in muscle cells. Melnikova, I.N., Bounpheng, M., Schatteman, G.C., Gilliam, D., Christy, B.A. Exp. Cell Res. (1999)
- The balance between Pax5 and Id2 activities is the key to AID gene expression. Gonda, H., Sugai, M., Nambu, Y., Katakai, T., Agata, Y., Mori, K.J., Yokota, Y., Shimizu, A. J. Exp. Med. (2003)
- A role for Id proteins in mammary gland physiology and tumorigenesis. de Candia, P., Benera, R., Solit, D.B. Adv. Cancer Res. (2004)
- Receptor activator of NF-kappaB ligand regulates the proliferation of mammary epithelial cells via Id2. Kim, N.S., Kim, H.J., Koo, B.K., Kwon, M.C., Kim, Y.W., Cho, Y., Yokota, Y., Penninger, J.M., Kong, Y.Y. Mol. Cell. Biol. (2006)
- Role of Id proteins in B lymphocyte activation: new insights from knockout mouse studies. Sugai, M., Gonda, H., Nambu, Y., Yokota, Y., Shimizu, A. J. Mol. Med. (2004)
- Each member of the Id gene family exhibits a unique expression pattern in mouse gastrulation and neurogenesis. Jen, Y., Manova, K., Benezra, R. Dev. Dyn. (1997)
- Stage- and subcellular-specific expression of Id proteins in male germ and Sertoli cells implicates distinctive regulatory roles for Id proteins during meiosis, spermatogenesis, and Sertoli cell function. Sablitzky, F., Moore, A., Bromley, M., Deed, R.W., Newton, J.S., Norton, J.D. Cell Growth Differ. (1998)
- Nucleo-cytoplasmic shuttling of Id2, a negative regulator of basic helix-loop-helix transcription factors. Kurooka, H., Yokota, Y. J. Biol. Chem. (2005)
- Impairment of intestinal intraepithelial lymphocytes in Id2 deficient mice. Kim, J.K., Takeuchi, M., Yokota, Y. Gut (2004)
- 1alpha,25-Dihydroxyvitamin D3 regulates the expression of Id1 and Id2 genes and the angiogenic phenotype of human colon carcinoma cells. Fernandez-Garcia, N.I., Palmer, H.G., Garcia, M., Gonzalez-Martin, A., del Rio, M., Barettino, D., Volpert, O., Muñoz, A., Jimenez, B. Oncogene (2005)
- Id2 drives differentiation and suppresses tumor formation in the intestinal epithelium. Russell, R.G., Lasorella, A., Dettin, L.E., Iavarone, A. Cancer Res. (2004)
- Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells. Hollnagel, A., Oehlmann, V., Heymer, J., Rüther, U., Nordheim, A. J. Biol. Chem. (1999)
- Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages. Iavarone, A., King, E.R., Dai, X.M., Leone, G., Stanley, E.R., Lasorella, A. Nature (2004)
- Id helix-loop-helix proteins negatively regulate TRANCE-mediated osteoclast differentiation. Lee, J., Kim, K., Kim, J.H., Jin, H.M., Choi, H.K., Lee, S.H., Kook, H., Kim, K.K., Yokota, Y., Lee, S.Y., Choi, Y., Kim, N. Blood (2006)
- Inhibitors of differentiation and DNA binding (Ids) regulate Math1 and hair cell formation during the development of the organ of Corti. Jones, J.M., Montcouquiol, M., Dabdoub, A., Woods, C., Kelley, M.W. J. Neurosci. (2006)
- Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cells. Fukuyama, S., Hiroi, T., Yokota, Y., Rennert, P.D., Yanagita, M., Kinoshita, N., Terawaki, S., Shikina, T., Yamamoto, M., Kurono, Y., Kiyono, H. Immunity (2002)
- Mammary epithelial cells are not able to undergo pregnancy-dependent differentiation in the absence of the helix-loop-helix inhibitor Id2. Miyoshi, K., Meyer, B., Gruss, P., Cui, Y., Renou, J.P., Morgan, F.V., Smith, G.H., Reichenstein, M., Shani, M., Hennighausen, L., Robinson, G.W. Mol. Endocrinol. (2002)
- Identification of inhibitor-of-differentiation 2 (Id2) as a modulator of neuronal apoptosis. Gleichmann, M., Buchheim, G., El-Bizri, H., Yokota, Y., Klockgether, T., Kügler, S., Bähr, M., Weller, M., Schulz, J.B. J. Neurochem. (2002)