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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Abdominal Wall

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Disease relevance of Abdominal Wall


High impact information on Abdominal Wall

  • The plasma glucose responses to s.c. injection of this insulin into the anterior abdominal wall and to i.m. injection into the thigh were similar with respect to the extent, onset, and duration of effect [6].
  • Eyelids and the abdominal wall did not close properly in some Sox11-deficient mice [7].
  • Pitx2, a paired-related homeobox gene that encodes multiple isoforms, is the gene mutated in the haploinsufficient Rieger Syndrome type 1 that includes dental, ocular and abdominal wall anomalies as cardinal features [8].
  • Northern blot analysis of abdominal wall tissue showed that five of six talc-treated animals given placebo expressed mRNA for the murine monocyte chemoattractant protein-1 (MCP-1), JE [9].
  • OBJECTIVE: Large midline abdominal wall defects are continuously a challenge for reconstructive surgeons [10].

Chemical compound and disease context of Abdominal Wall


Biological context of Abdominal Wall

  • Furthermore, the frequency of altered DNA methylation of LIT1 in patients with midline abdominal-wall defects and macrosomia was significantly higher, 65% (41/63) and 60% (46/77), respectively, than in patients without such defects, 34% (10/29) and 18% (2/11), respectively (P=.012 and P=.02, respectively) [16].
  • In both groups the glycerol level in the microdialysate (lipolysis index) started to increase steadily from the start of the general anesthesia until the abdominal wall was closed [17].
  • Maternal serum alpha-fetoprotein in fetal neural tube and abdominal wall defects at 10 to 14 weeks of gestation [18].
  • In addition, the expression pattern of MyoD-lacZ transgenes in the intercostal and abdominal wall muscles of Myf-5-/- and MyoD-/- embryos suggests that appropriate development of these muscles is dependent on both genes and, therefore, these muscles have a dual embryonic origin (epaxial and hypaxial) [19].
  • Three weeks after surgery, serial cross-sections of the reconstructed abdominal wall were stained with hematoxylin and eosin or embryonic myosin antibody, a well-characterized molecular marker of early myogenesis in development and regeneration [20].

Anatomical context of Abdominal Wall


Associations of Abdominal Wall with chemical compounds

  • Diffusion chambers were affixed to the serosal side of the anterior abdominal wall of rats, and solutions containing radiolabeled urea or mannitol were placed in the chambers [26].
  • Using a depot testosterone formulation which provides stable, physiological range testosterone levels for up to 6 months, we studied nine men before and after insertion of six 200 mg testosterone implants under the abdominal wall skin and compared the results with 38 men treated in a previous study with weekly im injections of 200 mg TE [27].
  • Electrocautery, but not scalpel, incision of the porcine abdominal wall increased ethane levels significantly (p < .02) [28].
  • There was, however, extraskeletal uptake of the 99mTc bone tracer in the anterior abdominal wall confined to the sites of subcutaneous heparin administration [29].
  • At the time of incision (33 +/- 16 min after the injection), cefotetan concentrations were 14.2 +/- 7 micrograms/g in abdominal-wall fat, 16.4 +/- 1 micrograms/g in epiploic fat, and 163 +/- 62 mg/liter in serum [30].

Gene context of Abdominal Wall


Analytical, diagnostic and therapeutic context of Abdominal Wall


  1. Microdeletion of LIT1 in familial Beckwith-Wiedemann syndrome. Niemitz, E.L., DeBaun, M.R., Fallon, J., Murakami, K., Kugoh, H., Oshimura, M., Feinberg, A.P. Am. J. Hum. Genet. (2004) [Pubmed]
  2. Impaired abdominal wall development and deficient wound healing in mice lacking aortic carboxypeptidase-like protein. Layne, M.D., Yet, S.F., Maemura, K., Hsieh, C.M., Bernfield, M., Perrella, M.A., Lee, M.E. Mol. Cell. Biol. (2001) [Pubmed]
  3. Impact of gas(less) laparoscopy and laparotomy on peritoneal tumor growth and abdominal wall metastases. Bouvy, N.D., Marquet, R.L., Jeekel, H., Bonjer, H.J. Ann. Surg. (1996) [Pubmed]
  4. Neoplastic seeding complicating percutaneous ethanol injection for treatment of hepatocellular carcinoma. Cedrone, A., Rapaccini, G.L., Pompili, M., Grattagliano, A., Aliotta, A., Trombino, C. Radiology. (1992) [Pubmed]
  5. Abdominal wall hernia in autosomal dominant polycystic kidney disease. Morris-Stiff, G., Coles, G., Moore, R., Jurewicz, A., Lord, R. The British journal of surgery. (1997) [Pubmed]
  6. Comparative study of subcutaneous, intramuscular, and intravenous administration of human insulin. Owens, D.R., Jones, M.K., Hayes, T.M., Heding, L.G., Alberti, K.G., Home, P.D., Burrin, J.M. Lancet (1981) [Pubmed]
  7. Gene targeting reveals a widespread role for the high-mobility-group transcription factor Sox11 in tissue remodeling. Sock, E., Rettig, S.D., Enderich, J., Bösl, M.R., Tamm, E.R., Wegner, M. Mol. Cell. Biol. (2004) [Pubmed]
  8. Genetic dissection of Pitx2 in craniofacial development uncovers new functions in branchial arch morphogenesis, late aspects of tooth morphogenesis and cell migration. Liu, W., Selever, J., Lu, M.F., Martin, J.F. Development (2003) [Pubmed]
  9. Estrogen suppression of connective tissue deposition in a murine model of peritoneal adhesion formation. Frazier-Jessen, M.R., Mott, F.J., Witte, P.L., Kovacs, E.J. J. Immunol. (1996) [Pubmed]
  10. One-stage reconstruction of large midline abdominal wall defects using a composite free anterolateral thigh flap with vascularized fascia lata. Kuo, Y.R., Kuo, M.H., Lutz, B.S., Huang, Y.C., Liu, Y.T., Wu, S.C., Hsieh, K.C., Hsien, C.H., Jeng, S.F. Ann. Surg. (2004) [Pubmed]
  11. Tumor growth and dissemination after laparotomy and CO2 pneumoperitoneum: a rat ovarian cancer model. Canis, M., Botchorishvili, R., Wattiez, A., Mage, G., Pouly, J.L., Bruhat, M.A. Obstetrics and gynecology. (1998) [Pubmed]
  12. Induction of tolerance via skin depleted of Langerhans cells by a chemical carcinogen. Halliday, G.M., Muller, H.K. Cell. Immunol. (1986) [Pubmed]
  13. Effects of raloxifene in a guinea pig model for leiomyomas. Porter, K.B., Tsibris, J.C., Porter, G.W., Fuchs-Young, R., Nicosia, S.V., O'Brien, W.F., Spellacy, W.N. Am. J. Obstet. Gynecol. (1998) [Pubmed]
  14. Cytosolic calcium and insulin resistance in elderly patients with essential hypertension. Byyny, R.L., LoVerde, M., Lloyd, S., Mitchell, W., Draznin, B. Am. J. Hypertens. (1992) [Pubmed]
  15. Surgery for large intra-abdominal desmoid tumors: report of four cases. Middleton, S.B., Phillips, R.K. Dis. Colon Rectum (2000) [Pubmed]
  16. Epigenetic alterations of H19 and LIT1 distinguish patients with Beckwith-Wiedemann syndrome with cancer and birth defects. DeBaun, M.R., Niemitz, E.L., McNeil, D.E., Brandenburg, S.A., Lee, M.P., Feinberg, A.P. Am. J. Hum. Genet. (2002) [Pubmed]
  17. Lipolysis during abdominal surgery. Felländer, G., Nordenström, J., Tjäder, I., Bolinder, J., Arner, P. J. Clin. Endocrinol. Metab. (1994) [Pubmed]
  18. Maternal serum alpha-fetoprotein in fetal neural tube and abdominal wall defects at 10 to 14 weeks of gestation. Sebire, N.J., Spencer, K., Noble, P.L., Hughes, K., Nicolaides, K.H. British journal of obstetrics and gynaecology. (1997) [Pubmed]
  19. MyoD and Myf-5 define the specification of musculature of distinct embryonic origin. Kablar, B., Asakura, A., Krastel, K., Ying, C., May, L.L., Goldhamer, D.J., Rudnicki, M.A. Biochem. Cell Biol. (1998) [Pubmed]
  20. Reconstruction of ablated rat rectus abdominis by muscle regeneration. Vindigni, V., Mazzoleni, F., Rossini, K., Fabbian, M., Zanin, M.E., Bassetto, F., Carraro, U. Plast. Reconstr. Surg. (2004) [Pubmed]
  21. Effects of physiological hypercortisolemia on the regulation of lipolysis in subcutaneous adipose tissue. Samra, J.S., Clark, M.L., Humphreys, S.M., MacDonald, I.A., Bannister, P.A., Frayn, K.N. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  22. Markedly increased tissue concentrations of 7-dehydrocholesterol combined with low levels of cholesterol are characteristic of the Smith-Lemli-Opitz syndrome. Tint, G.S., Seller, M., Hughes-Benzie, R., Batta, A.K., Shefer, S., Genest, D., Irons, M., Elias, E., Salen, G. J. Lipid Res. (1995) [Pubmed]
  23. Significance of cyclooxygenase-2 induced via p38 mitogen-activated protein kinase in mechanical stimulus-induced peritoneal adhesion in mice. Katada, J., Saito, H., Ohashi, A. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  24. Urethral and genital malformations in prune belly syndrome. Kroovand, R.L., Al-Ansari, R.M., Perlmutter, A.D. J. Urol. (1982) [Pubmed]
  25. Axonal sprouting of a brainstem-spinal pathway after estrogen administration in the adult female rhesus monkey. Vanderhorst, V.G., Terasawa, E., Ralston, H.J. J. Comp. Neurol. (2002) [Pubmed]
  26. A method to test blood flow limitation of peritoneal-blood solute transport. Kim, M., Lofthouse, J., Flessner, M.F. J. Am. Soc. Nephrol. (1997) [Pubmed]
  27. Suppression of human spermatogenesis by testosterone implants. Handelsman, D.J., Conway, A.J., Boylan, L.M. J. Clin. Endocrinol. Metab. (1992) [Pubmed]
  28. Ethane: a marker of lipid peroxidation during cardiopulmonary bypass in humans. Andreoni, K.A., Kazui, M., Cameron, D.E., Nyhan, D., Sehnert, S.S., Rohde, C.A., Bulkley, G.B., Risby, T.H. Free Radic. Biol. Med. (1999) [Pubmed]
  29. Extraskeletal uptake of technetium-99m-MDP in sites of heparin administration. Challa, S., Miller, J.H. J. Nucl. Med. (1998) [Pubmed]
  30. Pharmacokinetics and tissue penetration of single-dose cefotetan used for antimicrobial prophylaxis in patients undergoing colorectal surgery. Martin, C., Portet, C., Lambert, D., Bruguerolle, B., Sastre, B., De Micco, P., Gouin, F. Antimicrob. Agents Chemother. (1992) [Pubmed]
  31. TNF-alpha promotes progression of peritoneal metastasis as demonstrated using a green fluorescence protein (GFP)-tagged human gastric cancer cell line. Mochizuki, Y., Nakanishi, H., Kodera, Y., Ito, S., Yamamura, Y., Kato, T., Hibi, K., Akiyama, S., Nakao, A., Tatematsu, M. Clin. Exp. Metastasis (2004) [Pubmed]
  32. Ventral abdominal wall dysmorphogenesis of Msx1/Msx2 double-mutant mice. Ogi, H., Suzuki, K., Ogino, Y., Kamimura, M., Miyado, M., Ying, X., Zhang, Z., Shinohara, M., Chen, Y., Yamada, G. The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology. (2005) [Pubmed]
  33. Embryonic development of folate binding protein-1 (Folbp1) knockout mice: Effects of the chemical form, dose, and timing of maternal folate supplementation. Spiegelstein, O., Mitchell, L.E., Merriweather, M.Y., Wicker, N.J., Zhang, Q., Lammer, E.J., Finnell, R.H. Dev. Dyn. (2004) [Pubmed]
  34. Chinese medicine compound Changtong oral liquid on postoperative intestinal adhesions. Yang, X.X., Shi, H.P., Hou, L.B. World J. Gastroenterol. (2005) [Pubmed]
  35. Heat preconditioning prevents oxidative stress-induced damage in the intestine and lung following surgical manipulation. Thomas, S., Pulimood, A., Balasubramanian, K.A. The British journal of surgery. (2003) [Pubmed]
  36. Respiratory mechanics during laparoscopic cholecystectomy: the effects of the abdominal wall lift. Carry, P.Y., Gallet, D., François, Y., Perdrix, J.P., Sayag, A., Gilly, F., Eberhard, A., Banssillon, V., Baconnier, P. Anesth. Analg. (1998) [Pubmed]
  37. Preincisional local anesthesia with bupivacaine and pain after laparoscopic cholecystectomy. A double-blind randomized clinical trial. Ure, B.M., Troidl, H., Spangenberger, W., Neugebauer, E., Lefering, R., Ullmann, K., Bende, J. Surgical endoscopy. (1993) [Pubmed]
  38. Laparoscopic injury of abdominal wall blood vessels: a report of three cases. Hurd, W.W., Pearl, M.L., DeLancey, J.O., Quint, E.H., Garnett, B., Bude, R.O. Obstetrics and gynecology. (1993) [Pubmed]
  39. Interaction between oxytocin and prostaglandin F2 alpha in human corpus luteum? Bennegård-Edén, B., Hahlin, M., Kindahl, H. Hum. Reprod. (1995) [Pubmed]
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