Psychiatry related information on Vitamin A Deficiency

• Comprehensive recommendations for the assessment and control of vitamin A deficiency (VAD) were rigorously reviewed and revised by a working group and presented for discussion at the XX International Vitamin A Consultative Group meeting in Hanoi, Vietnam [1].

High impact information on Vitamin A Deficiency

• Mice fed a semipurified, vitamin A-deficient diet (A- mice) and control animals fed the same diet with added retinyl acetate (A+ mice) were used to investigate the effect of vitamin A deficiency on primary immunoglobulin responses to protein antigens [2].
• In contrast, RXR alpha af1(o)/RAR(-/-)(alpha, beta or gamma) compound mutants die in utero and exhibit a large array of malformations that nearly recapitulate the full spectrum of the defects that characterize the fetal vitamin A-deficiency (VAD) syndrome [3].
• A field evaluation in a population at risk for vitamin A deficiency (VAD) resulted in close correlation between RBP EIA measures and retinol measures by HPLC (R(2) = 0.82) [4].
• Two biochemical indicators are currently recommended for determining whether vitamin A deficiency (VAD) is a public health problem: serum retinol and serum retinol-binding protein (RBP) [5].
• Finally, daily administration of retinoic acid (RA) failed to reverse the 39-week Vitamin A deficiency (VAD)-related cognitive deficit and to fully normalise the associated brain retinoid hyposignalling [6].

Chemical compound and disease context of Vitamin A Deficiency

• In vitamin A deficiency (VAD), both serum retinol and RBP decline [7].
• Effect of gestational age and retinol (vitamin A) deficiency on fetal rat lung nuclear retinoic acid receptors [8].
• Tissue changes induced by vitamin A deficiency and RA administration were evaluated histologically in incisors of rats fed on one of 3 different diets: a) vitamin A sufficient (A+); b) vitamin A deficient (A-); and c) vitamin A deficient supplemented with retinoic acid (A-/RA) [9].
• Sardine oil rich in retinyl esters to fight vitamin a deficiency in Kingdom of Morocco [10].

Biological context of Vitamin A Deficiency

• The aim of this study was to elucidate the level of anaemia and vitamin A deficiency (VAD) in peri-urban breast-feeding women and their young infants [11].

Gene context of Vitamin A Deficiency

• Previous investigations in mice have shown that vitamin A deficiency (VAD) generates a hypo-expression of retinoic acid (RA, the active metabolite of vitamin A) receptors and of neurogranin (RC3, a neuronal protein involved in synaptic plasticity) and a concomitant selective behavioural impairment [12].
• We showed previously that the proliferation of hamster airway secretory cells decreases during vitamin A deficiency (VAD) but later increases when submucosal inflammation develops (Virchows Arch [B] 59:231-242, 1990) [13].

References