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Chemical Compound Review

Crystalets     [(2E,4E,6E,8E)-3,7-dimethyl- 9-(2,6,6...

Synonyms: Acetylretinol, AC1LCVIC, Davitan A 650, CHEMBL486193, CCRIS 1907, ...
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Disease relevance of Crystalets


High impact information on Crystalets

  • Influence of dietary retinyl acetate on normal rat mammary gland development and on the enhancement of 7,12-dimethylbenz[a]anthracene-induced rat mammary tumorigenesis by high levels of dietary fat [6].
  • The effect of high levels of dietary fat and retinyl acetate (ROA) on 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumor development and growth was examined [6].
  • The carcinogenicity of retinol acetate [(RAC) CAS: 127-47-9], a synthetic derivative of retinol, was tested by continuous oral administration in the drinking water of F344/DuCrj rats for 104 weeks [7].
  • Retinyl acetate induced the formation of numerous vacuoles and periodic acid-silver methenamine-positive granules in both T-8 and 1000 WT cells [1].
  • After T-8 cells were cultured for 7 days in 6.6 x 10(-6) or 3.3 x 10(-5) M retinyl acetate, [3H]glucosamine incorporation increased 133- to 147-fold and [14C]serine incorporation increased twelvefold to twentyfold in the high-molecular-weight mucous glycoprotein fraction (peak A) from the cell cytosol [1].

Chemical compound and disease context of Crystalets


Biological context of Crystalets


Anatomical context of Crystalets


Associations of Crystalets with other chemical compounds


Gene context of Crystalets


Analytical, diagnostic and therapeutic context of Crystalets

  • Comparison of ovariectomy and retinyl acetate on the growth of established 7,12-dimethylbenz[a]anthracene-induced mammary tumors in the rat [30].
  • The mean coefficient of variation for the internal standard retinyl acetate in serum was 4.16% for the high-pressure liquid chromatography method used [31].
  • Plasma samples obtained from 12:00 P.M. (noon) until 12 A.M. (midnight) were subjected to ultracentrifugation, and measurements were made of TG and vitamin A ester concentrations in plasma and in both the Svedberg flotation constant (Sf) > 400 (chylomicron) and Sf 20-400 (chylomicron remnant) lipoprotein fractions [32].
  • Feeding of retinyl acetate (0.2 mM) or N-(4-hydroxyphenyl) retinamide (4-HPR) (1.0 mM) for 27 weeks to female BD2F1 mice previously treated with a series of gastric intubations of 7,12-dimethylbenzanthracene (DMBA), did not significantly affect the incidence of mammary tumors [33].
  • Marmosets were fed a powder-based diet consisting of 20 IU (6 RE) retinyl acetate/g. The marmosets consumed an estimated 25 g of the diet/d. Liver samples were extracted and analyzed by HPLC [34].


  1. Modulation of growth, differentiation, and mucous glycoprotein synthesis by retinyl acetate in cloned carcinoma cell lines. Marchok, A.C., Clark, J.N., Klein-Szanto, A. J. Natl. Cancer Inst. (1981) [Pubmed]
  2. Comparative subacute toxicity of retinyl acetate and three synthetic retinamides in Swiss mice. Hixson, E.J., Denine, E.P. J. Natl. Cancer Inst. (1979) [Pubmed]
  3. Effect of retinyl acetate on the incidence of mammary carcinomas and hepatomas in mice. Maiorana, A., Gullino, P.M. J. Natl. Cancer Inst. (1980) [Pubmed]
  4. Inhibition of benz[a]pyrene-induced mammary carcinogenesis by retinyl acetate. McCormick, D.L., Burns, F.J., Albert, R.E. J. Natl. Cancer Inst. (1981) [Pubmed]
  5. Characterization of the inhibitory effects of retinoids on the in vitro growth of two malignant murine melanomas. Lotan, R., Giotta, G., Nork, E., Nicolson, G.L. J. Natl. Cancer Inst. (1978) [Pubmed]
  6. Influence of dietary retinyl acetate on normal rat mammary gland development and on the enhancement of 7,12-dimethylbenz[a]anthracene-induced rat mammary tumorigenesis by high levels of dietary fat. Aylsworth, C.F., Cullum, M.E., Zile, M.H., Welsch, C.W. J. Natl. Cancer Inst. (1986) [Pubmed]
  7. High incidences of pheochromocytomas after long-term administration of retinol acetate to F344/DuCrj rats. Kurokawa, Y., Hayashi, Y., Maekawa, A., Takahashi, M., Kukubo, T. J. Natl. Cancer Inst. (1985) [Pubmed]
  8. Influence of delayed administration of retinyl acetate on mammary carcinogenesis. McCormick, D.L., Moon, R.C. Cancer Res. (1982) [Pubmed]
  9. Vitamin A storage and peroxisomes in retinal pigment epithelium and liver. Robison, W.G., Kuwabara, T. Invest. Ophthalmol. Vis. Sci. (1977) [Pubmed]
  10. Zinc-vitamin A interaction in pregnant and fetal rats: supplemental vitamin A does not prevent zinc-deficiency-induced teratogenesis. Peters, A.J., Keen, C.L., Lönnerdal, B., Hurley, L.S. J. Nutr. (1986) [Pubmed]
  11. Influence of dose and pharmaceutical formulation of vitamin A on plasma levels of retinyl esters and retinol and metabolic generation of retinoic acid compounds and beta-glucuronides in the cynomolgus monkey. Eckhoff, C., Bailey, J.R., Collins, M.D., Slikker, W., Nau, H. Toxicol. Appl. Pharmacol. (1991) [Pubmed]
  12. Phase II study of tamoxifen and high-dose retinyl acetate in patients with advanced breast cancer. Boccardo, F., Canobbio, L., Resasco, M., Decensi, A.U., Pastorino, G., Brema, F. J. Cancer Res. Clin. Oncol. (1990) [Pubmed]
  13. Inhibition of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis by retinyl acetate. Moon, R.C., Grubbs, C.J., Sporn, M.B. Cancer Res. (1976) [Pubmed]
  14. Spontaneous transfer of retinoic acid, retinyl acetate, and retinyl palmitate between single unilamellar vesicles. Ho, M.T., Pownall, H.J., Hollyfield, J.G. J. Biol. Chem. (1989) [Pubmed]
  15. Isolation and characterization of vitamin A-sensitive Chinese hamster lung cell lines. Ikezaki, K., Akiyama, S., Nakamura, M., Komiyama, S., Kuwano, M. J. Cell. Physiol. (1983) [Pubmed]
  16. Effect of reduced body weight gain on the evaluation of chemopreventive agents in the methylnitrosourea-induced mammary cancer model. Rodríguez-Burford, C., Lubet, R.A., Eto, I., Juliana, M.M., Kelloff, G.J., Grubbs, C.J., Steele, V.E. Carcinogenesis (1999) [Pubmed]
  17. Structure-activity relationships of retinoids in the morphogenesis of cutaneous appendages in the chick embryo. Cadi, R., Pautou, M.P., Dhouailly, D. J. Invest. Dermatol. (1984) [Pubmed]
  18. Comparison of the level of cellular retinoid-binding proteins and susceptibility to retinoid-induced growth inhibition of various neoplastic cell lines. Lotan, R., Ong, D.E., Chytil, F. J. Natl. Cancer Inst. (1980) [Pubmed]
  19. Regulation by vitamin A of envelope cross-linking in cultured keratinocytes derived from different human epithelia. Green, H., Watt, F.M. Mol. Cell. Biol. (1982) [Pubmed]
  20. Dexamethasone and retinyl acetate similarly inhibit and stimulate EGF- or insulin-induced proliferation of prostatic epithelium. Chaproniere, D.M., Webber, M.M. J. Cell. Physiol. (1985) [Pubmed]
  21. Retinyl acetate inhibits platelet-derived growth factor-induced Ca2+ signals in C3H 10T1/2 fibroblasts. Hill, T.D., Boynton, A.L., Dean, N.M., Mordan, L.J. J. Cell. Physiol. (1990) [Pubmed]
  22. Inhibitory effects of retinoic acid or retinyl acetate on the growth of untransformed, transformed, and tumor cells in vitro. Lotan, R., Nicolson, G.L. J. Natl. Cancer Inst. (1977) [Pubmed]
  23. Quinoline: conversion to a mutagen by human and rodent liver. Hollstein, M., Talcott, R., Wei, E. J. Natl. Cancer Inst. (1978) [Pubmed]
  24. Vitamin A and benzo(a)pyrene carcinogenesis in the respiratory tract of hamsters fed a semisynthetic diet. Smith, D.M., Rogers, A.E., Newberne, P.M. Cancer Res. (1975) [Pubmed]
  25. Retinoids and cancer prevention. Hill, D.L., Grubbs, C.J. Annu. Rev. Nutr. (1992) [Pubmed]
  26. Impaired vitamin A-mediated mucosal IgA response in IL-5 receptor-knockout mice. Nikawa, T., Ikemoto, M., Kano, M., Tokuoka, K., Hirasaka, K., Uehara, S., Takatsu, K., Rokutan, K., Kishi, K. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  27. Rat cellular retinol-binding protein: cDNA sequence and rapid retinol-dependent accumulation of mRNA. Sherman, D.R., Lloyd, R.S., Chytil, F. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  28. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and polycyclic aromatic hydrocarbons suppress retinoid-induced tissue transglutaminase in SCC-4 cultured human squamous carcinoma cells. Rubin, A.L., Rice, R.H. Carcinogenesis (1988) [Pubmed]
  29. Effect of retinyl acetate on the assembly of the fibronectin extracellular matrix and the processing of the fibronectin receptor beta subunit of confluent C3H/10T1/2 mouse embryo fibroblasts. Suzuki, S.S., Piette, L.H. J. Cell. Biochem. (1993) [Pubmed]
  30. Comparison of ovariectomy and retinyl acetate on the growth of established 7,12-dimethylbenz[a]anthracene-induced mammary tumors in the rat. Gandilhon, P., Melancon, R., Djiane, J., Kelly, P.A. J. Natl. Cancer Inst. (1982) [Pubmed]
  31. Etretinate blood levels in monitoring of compliance and contamination in a chemoprevention trial. Browman, G.P., Arnold, A., Booker, L., Johnstone, B., Skingley, P., Levine, M.N. J. Natl. Cancer Inst. (1989) [Pubmed]
  32. Why do low-fat high-carbohydrate diets accentuate postprandial lipemia in patients with NIDDM? Chen, Y.D., Coulston, A.M., Zhou, M.Y., Hollenbeck, C.B., Reaven, G.M. Diabetes Care (1995) [Pubmed]
  33. Lack of an effect of dietary retinoids in chemical carcinogenesis of the mouse mammary gland: inverse relationship between mammary tumor cell anaplasia and retinoid efficacy. Welsch, C.W., DeHoog, J.V., Moon, R.C. Carcinogenesis (1984) [Pubmed]
  34. Subtoxic hepatic vitamin A concentrations in captive rhesus monkeys (Macaca mulatta). Penniston, K.L., Tanumihardjo, S.A. J. Nutr. (2001) [Pubmed]
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