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MeSH Review:

Contraception, Immunologic

Miller, L.A. et al., Li, H.G. et al., Jackson, R.J. et al., Miller, L.A. et al., Naz, R.K. et al., et al.

Naz, Zhu, Miller, Johns, Elias, Crane, O'rand, Widgren, Sivashanmugam, Richardson, Hall, French, VandeVoort, Ramachandra, Ramesh, Jagannadha Rao, Jackson, Maguire, Hinds, Ramshaw, Pöllänen, Cooper, Kokk, Saari, Setchell, Koyama, Hasegawa, Gupta,

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Disease relevance of Contraception, Immunologic

We have tested the concept that immunocontraception can be achieved with a recombinant ectromelia virus expressing an ovary-specific antigen, the mouse zona pellucida 3 (ZP3) glycoprotein [1].
Oral vaccination of white-tailed deer using a recombinant Bacillus Calmette-Guérin vaccine expressing the Borrelia burgdorferi outer surface protein A: prospects for immunocontraception [2].

High impact information on Contraception, Immunologic

The sperm-specific human FA-1 recombinant antigen may find applications in immunocontraception, and diagnosis and treatment of immunoinfertility in humans [3].
A male genital tract-specific carbohydrate epitope on human CD52: implications for immunocontraception [4].
In this study we have examined the potential of recombinant mouse zona pellucida glycoprotein 2 (ZP2) as a target for immunocontraception [5].
As part of our research program to develop immunocontraception as a wildlife management tool, we compared the physiological responses of wild Norway rats (Rattus norvegicus) to two immunocontraceptive vaccines; one involved mouse zona pellucida peptide (MZPP); the other involved gonadotropin releasing hormone (GnRH) [6].
The results showed that ZP3 immunization with permissible adjuvants could be used for immunocontraception without obvious ovarian changes [7].

Biological context of Contraception, Immunologic

Comparison of ZP3 protein sequences among vertebrate species: to obtain a consensus sequence for immunocontraception [8].
The influence of anti-human CATSPER1 antibody upon human sperm motility was used to evaluate the function of human CATSPER1 and to estimate its possible use as a target for immunocontraception [9].

Associations of Contraception, Immunologic with chemical compounds

The main difficulty of immunocontraception in the male is the poor access of antibodies to the luminal compartment [10].
Prospect for immunocontraception using the NH2-terminal recombinant peptide of human zona pellucida protein (hZPA) [11].

Gene context of Contraception, Immunologic

CONCLUSIONS: Collectively, these data suggest that amino acids within hFSH-beta 33-53 are necessary but not sufficient to confer immunocontraception [12].
In addition, our results suggest that human CATSPER1 could be a possible target for immunocontraception [9].
Application of a gene vaccine targeting HER-2/neu in immunocontraception [13].
A chimeric protein containing both hLH-R and hCG-beta would provide a unique bifunctional antigen for immunocontraception [14].
Reversible immunocontraception in male monkeys immunized with eppin [15].

References

Infertility in mice induced by a recombinant ectromelia virus expressing mouse zona pellucida glycoprotein 3. Jackson, R.J., Maguire, D.J., Hinds, L.A., Ramshaw, I.A. Biol. Reprod. (1998) [Pubmed]
Oral vaccination of white-tailed deer using a recombinant Bacillus Calmette-Guérin vaccine expressing the Borrelia burgdorferi outer surface protein A: prospects for immunocontraception. Miller, L.A., Johns, B.E., Elias, D.J., Killian, G.J. Am. J. Reprod. Immunol. (1999) [Pubmed]
Molecular cloning and sequencing of cDNA encoding for human FA-1 antigen. Naz, R.K., Zhu, X. Mol. Reprod. Dev. (2002) [Pubmed]
A male genital tract-specific carbohydrate epitope on human CD52: implications for immunocontraception. Norton, E.J., Diekman, A.B., Westbrook, V.A., Mullins, D.W., Klotz, K.L., Gilmer, L.L., Thomas, T.S., Wright, D.C., Brisker, J., Engelhard, V.H., Flickinger, C.J., Herr, J.C. Tissue Antigens (2002) [Pubmed]
Analysis of recombinant mouse zona pellucida protein 2 (ZP2) constructs for immunocontraception. Lea, I.A., Widgren, E.E., O'Rand, M.G. Vaccine (2002) [Pubmed]
Comparative efficacy of two immunocontraceptive vaccines. Miller, L.A., Johns, B.E., Elias, D.J., Crane, K.A. Vaccine (1997) [Pubmed]
Antifertility effects of porcine zona pellucida-3 immunization using permissible adjuvants in female bonnet monkeys (Macaca radiata): reversibility, effect on follicular development and hormonal profiles. Bagavant, H., Thillai-Koothan, P., Sharma, M.G., Talwar, G.P., Gupta, S.K. J. Reprod. Fertil. (1994) [Pubmed]
Comparison of ZP3 protein sequences among vertebrate species: to obtain a consensus sequence for immunocontraception. Zhu, X., Naz, R.K. Front. Biosci. (1999) [Pubmed]
The expression and significance of CATSPER1 in human testis and ejaculated spermatozoa. Li, H.G., Liao, A.H., Ding, X.F., Zhou, H., Xiong, C.L. Asian J. Androl. (2006) [Pubmed]
Microvascular permeability to the F(ab')2 fragment of IgG in the male rat reproductive tract at puberty. Pöllänen, P., Cooper, T.G., Kokk, K., Saari, T., Setchell, B.P. J. Reprod. Immunol. (1997) [Pubmed]
Prospect for immunocontraception using the NH2-terminal recombinant peptide of human zona pellucida protein (hZPA). Koyama, K., Hasegawa, A., Gupta, S.K. Am. J. Reprod. Immunol. (2002) [Pubmed]
Immunoneutralization of heterodimeric FSH using FSH beta subunit as the immunogen. Butterstein, G.M., Sachar, D., Dias, J.A. Am. J. Reprod. Immunol. (1993) [Pubmed]
Application of a gene vaccine targeting HER-2/neu in immunocontraception. Ni, J., Ni, Y., Wang, X., Xu, W., Wang, Y., Xiong, S. DNA Cell Biol. (2004) [Pubmed]
Expression of a recombinant bifunctional protein from a chimera of human lutropin receptor and human chorionic gonadotropin beta-subunit. Hao, M., Rathnam, P., Saxena, B. J. Reprod. Immunol. (2004) [Pubmed]
Reversible immunocontraception in male monkeys immunized with eppin. O'rand, M.G., Widgren, E.E., Sivashanmugam, P., Richardson, R.T., Hall, S.H., French, F.S., VandeVoort, C.A., Ramachandra, S.G., Ramesh, V., Jagannadha Rao, A. Science (2004) [Pubmed]

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