Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

CATSPER1 - cation channel, sperm associated 1

Homo sapiens

Synonyms: CATSPER, CatSper1, Cation channel sperm-associated protein 1, SPGF7, hCatSper

Li, H.G. et al., Podlaha, O. et al., Zhang, D. et al.

Zhang, Chen, Saraf, Cassar, Han, Rogers, Brioni, Sullivan, Gopalakrishnan,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CATSPER1

CATSPER1 mRNA in human ejaculated spermatozoa could be a more feasible target for study and infertility screening than testis biopsy [1].

High impact information on CATSPER1

This finding suggests that the selection detected may be related to the regulation of the CATSPER1 channel, which can affect sperm motility, an important determinant in sperm competition [2].
We determined the DNA sequences of the first exon of the CATSPER1 gene from 15 primates, which encodes the intracellular N terminus region of approximately equal to 400 aa [2].
CATSPER1 is a voltage-gated calcium channel found exclusively in the plasma membrane of the mammalian sperm tail and it is essential for sperm motility [2].
Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity [3].
The expression and significance of CATSPER1 in human testis and ejaculated spermatozoa [1].

Biological context of CATSPER1

Methods: Human ejaculated sperm from normozoospermic donors (n=12) and liquid nitrogen frozen human testis were used for the study of mRNA and protein expression of CATSPER1 by reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemistry, respectively [1].

Anatomical context of CATSPER1

Conclusion: CATSPER1 is meiotically and post-meiotically expressed in human testis tissue [1].
Results: CATSPER1 transcript was detected in both human testis and each human ejaculated semen sample [1].

Analytical, diagnostic and therapeutic context of CATSPER1

In addition, our results suggest that human CATSPER1 could be a possible target for immunocontraception [1].

References

The expression and significance of CATSPER1 in human testis and ejaculated spermatozoa. Li, H.G., Liao, A.H., Ding, X.F., Zhou, H., Xiong, C.L. Asian J. Androl. (2006) [Pubmed]
Positive selection on protein-length in the evolution of a primate sperm ion channel. Podlaha, O., Zhang, J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity. Zhang, D., Chen, J., Saraf, A., Cassar, S., Han, P., Rogers, J.C., Brioni, J.D., Sullivan, J.P., Gopalakrishnan, M. J. Biol. Chem. (2006) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.