Disease relevance of Aortic Rupture

• Mutations in the COL3A1 gene have been implicated as a cause of type IV Ehlers-Danlos syndrome, a disease leading to aortic rupture in early adult life [1].
• Sudden death from aortic rupture prompted discontinuing this operation and evaluating 39 patients (16 girls; mean age 6.3 years, range 10 days to 14.5 years) undergoing repair between January 1976 and October 1987 [2].
• RESULTS: At macroscopic examination, 197 SCD victims (72%) had an overt underlying structural heart disease such as cardiomyopathy in 56, obstructive coronary atherosclerosis in 54, valve disease in 32, non-atherosclerotic coronary artery disease in 28, aortic rupture in 13, postoperative congenital heart disease in five, and other disease in nine [3].
• PURPOSE: Analysis endpoints of patient survival and aortic rupture at a reporting interval of 12 months are regularly used to compare endograft aortic aneurysm (EAG) repair to conventional open surgical (COS) repair [4].
• These experiments establish the role of hydrocortisone in the induction of aortic rupture in a mouse with genetic susceptibility and the induction of aneurysms and ectasia in normal mice [5].

High impact information on Aortic Rupture

• Effect of hydralazine on aortic rupture induced by B-aminopropionitrile in turkeys [6].
• Fbn1-/- mice died soon after birth from ruptured aortic aneurysm, impaired pulmonary function, and/or diaphragmatic collapse [7].
• The second was to evaluate the efficacy of beta-blockers with or without nitroprusside in preventing aortic rupture [8].
• Although aortic rupture is an unusual manifestation of MELAS, it is an important potential complication in patients undergoing minor surgical procedures [9].
• D-lactate has been recently proposed as a specific marker of gut ischemia-reperfusion (IR), particularly after surgery for ruptured aortic aneurysms [10].

Chemical compound and disease context of Aortic Rupture

• Relation of hemodynamics to the incidence of diethylstilbestrol-induced aortic ruptures in hypertensive and hypotensive lines of turkeys [11].
• Hydrocortisone rapidly induces aortic rupture in a genetically susceptible mouse [5].
• Influence of d-, l-, and dl-propranolol, and practolol on beta-amino-propionitrile-induced aortic ruptures of turkeys [12].
• Frontal chest radiographs from 54 patients with traumatic fractures of at least one vertebral body from C6 to T8 were examined for signs suggestive of aortic rupture [13].
• The copper and molybdenum contents in the livers of 12 turkeys that had succumbed to naturally occuring aortic ruptures were measured to determine if field cases of the disease are etiologically related to copper deficiency [14].

Gene context of Aortic Rupture

• Influence of thyroactive iodinated casein on B-aminopropionitrile-induced aortic ruptures of turkeys [15].
• This paper presents a case of left-sided vena cava which mimicked an aortic rupture on chest roentgenogram [16].
• Spontaneous aortic rupture associated with chronic steroid therapy for rheumatoid arthritis in two cases [17].
• A 34-year-old man was injured in a motorcycle accident and suffered both aortic rupture and thoracic spinal fracture, complicated by an underlying undetected ankylosing spondylitis [18].
• Such localized degenerative change was considered to be caused by circulatory disturbance which originated from disruption of the vasa vasorum due to aortic rupture [19].

Analytical, diagnostic and therapeutic context of Aortic Rupture

• We believe intravenous administration (0.5 to 2 micrograms/kg/min) of argatroban is a safe anticoagulant for left heart bypass in repairs of traumatic aortic rupture associated with multiple organ injuries [20].

References