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Chemical Compound Review

practolol     N-[4-[2-hydroxy-3-(propan-2...

Synonyms: Eraldin, Practalol, Teranol, Dalzic, Practololo, ...
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Disease relevance of Dalzic


Psychiatry related information on Dalzic


High impact information on Dalzic

  • Neither dose of practolol altered base-line heart rate, forearm vascular resistance, and arterial pressure, Both low and high doses significantly attenuated heart rate responses to exercise [8].
  • The results indicate that the phenomenon of selective beta-1 receptor blockade in man is related to the dose and serum concentration of practolol selectively block beta-1 receptors; a high dose and serum concentrations block both beta-1 and beta-2 receptors [8].
  • This effect could be blocked by the beta-adrenergic receptor antagonist, propranolol, but not by the specific beta 1-adrenergic receptor antagonist, practolol [9].
  • Second, the consistency of the effects observed with respect to pulse, transmural infarction, age and infarct site are in contrast to some previous studies with practolol, propranolol, and alprenolol [10].
  • Computer analysis of competition of [125I]iodocyanopindolol binding by betaxolol, practolol, and zinterol in nonmyocyte membranes demonstrates biphasic curves that comprise binding to both beta 1- and beta 2-receptors [11].

Chemical compound and disease context of Dalzic

  • In normal subjects, about 30% reduction in exercise-induced tachycardia resulted from single doses of 80 mg propranolol (plasma levels, 50.3, SD, 29.5 to 60.8, SD, 26 ng/ml), 250 mg practolol (plasma levels, 1.05, SD, 0.32 to 1.10, SD, 0.55 mug/ml), 100 mg metoprolol (plasma levels, 137, SD, 111 to 152, SD, 100 ng/ml), and 100 mg tolamolol [12].
  • (The treated animals grew less rapidly than the controls; when corrected for body weight these figures were -11.9% and -20.4%, respectively.) In the practolol group, but not the propranolol group, the duration of the atrial intracellular potentials was prolonged [13].
  • Also, these findings are not consistent with the Meerson hypothesis, since hypertrophy occurred despite the reduction in myocardial O2 consumption due to practolol [14].
  • The effects of dl-propranolol, d-propranolol, butoxamine or practolol on erythropoietin (ESF) production in rabbits exposed to hypoxia (0.42 atmosphere) for 18 hours were investigated [15].
  • 1 The degree of beta-adrenoceptor blockade of isoprenaline-induced tachycardia has been determined in three healthy volunteers after the administration of single oral doses of acebutolol, practolol or propranolol [16].

Biological context of Dalzic


Anatomical context of Dalzic

  • Differences between the effects of practolol and propranolol on the diastolic properties of the left ventricle [20].
  • It was shown in isolated smooth muscle from both man and guinea pig that the order of potency for the three beta-blocking agents studied was: propranolol greater than sotalol greater than practolol [22].
  • Practolol was the least effective beta adrenergic-blocking agent in degranulating mast cells [23].
  • In order to investigate further the effects of this beta blocking agent, myocardial function and metabolism at rest and during supine exercise were assessed in 12 male patients with coronary artery disease before and after practolol 30 mg, iv [21].
  • Neither practolol nor propranolol significantly altered the volume or distribution of blood flow into the normally perfused or ischaemicmyocardial areas, while beta2 stimulation increased blood flow to the normally perfused myocardium from 1.13 +/- 0.12 to 1.28 +/- 1.10 cm3 .min-1 .g-1 (P <0.05) [24].

Associations of Dalzic with other chemical compounds


Gene context of Dalzic


Analytical, diagnostic and therapeutic context of Dalzic


  1. Respiratory disease associated with practolol therapy. Marshall, A.J., Eltringham, W.K., Barritt, D.W., Davies, J.D., Griffiths, D.A., Jackson, L.K., Laszlo, G., Read, A.E. Lancet (1977) [Pubmed]
  2. Effects of long-term practolol therapy on plasma-lipids after acute myocardial infarction. Ghosh, P., Cochrane, A.M., de Bono, D. Lancet (1975) [Pubmed]
  3. Chronic obstructive lung disease after practolol. Bartsch, P. Lancet (1977) [Pubmed]
  4. Letter: Pleural effusions after practolol. MacKAY, A.D., Axford, A.T. Lancet (1976) [Pubmed]
  5. Letter: Practolol and migraine. Sales, F., Bada, J.L. Lancet (1975) [Pubmed]
  6. Cutaneous reactions to propranolol (Inderal). Jensen, H.A., Mikkelsen, H.I., Wadskov, S., Sondergaard, J. Acta medica Scandinavica. (1976) [Pubmed]
  7. Circadian phase dependency of the effects of different beta-receptor blocking drugs on motor activity of rats. Importance of drug lipophilicity. Lemmer, B., Neumann, G. Arzneimittel-Forschung. (1987) [Pubmed]
  8. Selective beta-1 receptor blockade with oral practolol in man. A dose-related phenomenon. Lertora, J.J., Mark, A.L., Johannsen, J., Wilson, W.R., Abboud, F.M. J. Clin. Invest. (1975) [Pubmed]
  9. Direct stimulation of beta 2-adrenergic receptors in rat anterior pituitary induces the release of adrenocorticotropin in vivo. Mezey, E., Reisine, T.D., Palkovits, M., Brownstein, M.J., Axelrod, J. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  10. The Timolol Myocardial Infarction Study: an evaluation of selected variables. Rodda, B.E. Circulation (1983) [Pubmed]
  11. Direct analysis of beta-adrenergic receptor subtypes on intact adult ventricular myocytes of the rat. Buxton, I.L., Brunton, L.L. Circ. Res. (1985) [Pubmed]
  12. Effects of cardioselective beta adrenoceptor blockade on specific airways resistance in normal subjects and in patients with bronchial asthma. Singh, B.N., Whitlock, R.M., Comber, R.H., Williams, F.H., Harris, E.A. Clin. Pharmacol. Ther. (1976) [Pubmed]
  13. The effects of prolonged beta-adrenoceptor blockade on heart weight and cardiac intracellular potentials in rabbits. Williams, E.M., Raine, A.E., Cabrera, A.A., Whyte, J.M. Cardiovasc. Res. (1975) [Pubmed]
  14. Role of adrenergic mechanisms in the development of cardiac hypertrophy. Malik, A.B., Geha, A.S. Proc. Soc. Exp. Biol. Med. (1975) [Pubmed]
  15. Effects of beta adrenergic blocking agents on erythropoietin production in rabbits exposed to hypoxia. Fink, G.D., Paulo, L.G., Fisher, J.W. J. Pharmacol. Exp. Ther. (1975) [Pubmed]
  16. Plasma levels and beta-adrenoceptor blockade with acebutolol, practolol and propranolol in man. Cuthbert, M.F., Collins, R.F. British journal of clinical pharmacology. (1975) [Pubmed]
  17. Identification of alpha-adrenergic receptors in uterine smooth muscle membranes by [3H]dihydroergocryptine binding. Williams, L.T., Mullikin, D., Lefkowitz, R.J. J. Biol. Chem. (1976) [Pubmed]
  18. beta-Adrenergic receptors in rabbit liver plasma membranes. Predominance of beta 2-receptors and mediation of adrenergic regulation of hepatic glycogenolysis. Kawai, Y., Arinze, I.J. J. Biol. Chem. (1983) [Pubmed]
  19. Beta-adrenergic receptor blocking drugs in spontaneous hypertension. Levy, J.V. Am. J. Med. (1976) [Pubmed]
  20. Differences between the effects of practolol and propranolol on the diastolic properties of the left ventricle. Sniderman, A.D., Marpole, D.G., Fallen, E.L. Clin. Pharmacol. Ther. (1977) [Pubmed]
  21. Effects of practolol on exercise tolerance and cardiac haemodynamics and metabolism in patients with coronary artery disease. Dagenais, G.R., Moisan, A., Marquis, Y., Davies, R.O., Blouin, S. Cardiovasc. Res. (1976) [Pubmed]
  22. A comparison of the beta-blocking activities of practolol, sotalol, and propranolol in human and guinea pig tracheal smooth muscle. Adolphson, R.L., Townley, R.G. J. Allergy Clin. Immunol. (1976) [Pubmed]
  23. The effect of pertussis and beta adrenergic-blocking agents on mast cells. Guirgis, H.M., Townley, R.G. J. Allergy Clin. Immunol. (1976) [Pubmed]
  24. Effect of selective beta-adrenergic blockade and stimulation on regional myocardial blood flow following acute coronary artery occlusion in the awake dog. Melby, K., Bache, R.J. Cardiovasc. Res. (1980) [Pubmed]
  25. Inhibition of [3H]-dihydroalprenolol binding to rat cardiac membranes of various beta-blocking agents. Chenieux-Guicheney, P., Dausse, J.P., Meyer, P., Schmitt, H. Br. J. Pharmacol. (1978) [Pubmed]
  26. Investigation of the mechanism of propranolol-induced bronchoconstriction. Maclagan, J., Ney, U.M. Br. J. Pharmacol. (1979) [Pubmed]
  27. Comparison of the actions of acebutolol, practolol and propranolol on calcium transport by heart microsomes and mitochondria. Dhalla, N.S., Lee, S.L. Br. J. Pharmacol. (1976) [Pubmed]
  28. The beta 1- and beta 2-adrenoceptor stimulatory effects of alprenolol, oxprenolol and pindolol: a study in the isolated right atrium and uterus of the rat. Abrahamsson, T. Br. J. Pharmacol. (1986) [Pubmed]
  29. Beta 2-adrenoceptor stimulation inhibits ganglionic transmission in ferret trachea. Skoogh, B.E., Svedmyr, N. Pulmonary pharmacology. (1989) [Pubmed]
  30. Beta-adrenergic receptors of human leukocytes. Studies with intact mononuclear and polymorphonuclear cells and membranes comparing two radioligands in the presence and absence of chloroquine. Marinetti, G.V., Rosenfeld, S.I., Thiem, P.A., Condemi, J.J., Leddy, J.P. Biochem. Pharmacol. (1983) [Pubmed]
  31. Beta-adrenergic regulation of secretion from Clara cell adenomas of the mouse lung. Palmer, K.C., Grammas, P. Lab. Invest. (1987) [Pubmed]
  32. The effect of oxytocin on contractile responses and 45Ca movements in rat isolated aortic strips. Barrigón, S., Tamargo, J. Br. J. Pharmacol. (1986) [Pubmed]
  33. Normal myocardial contractile state in the presence of quinidine. Markiewicz, W., Winkle, R., Binetti, G., Kernoff, R., Harrison, D.C. Circulation (1976) [Pubmed]
  34. Acute vasodilator action of pindolol in humans. Chang, P.C., van Brummelen, P., Vermeij, P. Hypertension (1985) [Pubmed]
  35. Comparative effects of propranolol and practolol in the early stages of experimental canine myocardial infarction. Marshall, R.J., Parratt, J.R. Br. J. Pharmacol. (1976) [Pubmed]
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