Disease relevance of Spinal Fractures

• We have investigated biochemical indices of bone formation and bone resorption: serum alkaline phosphatase (sAP) plasma bone Gla protein (pBGP), fasting urinary hydroxyproline corrected for creatinine (FuHP/Cr), and fasting urinary calcium corrected for creatinine (FuCa/Cr) in 43 postmenopausal women with spinal fractures [1].
• Re: osteoporosis and spinal fractures in men with prostate cancer: risk factors and effects of androgen deprivation therapy [2].
• We describe an unusual complication of ankylosing spondylitis, hemothorax secondary to spinal fracture, that to our knowledge has not been previously reported [3].
• Patients with ankylosing spondylitis frequently experience back pain and they have a well-known propensity for spinal fractures, but they rarely manifest motor and sensory nerve root impairment [4].
• Pathology included rheumatoid arthritis in 11 patients, congenital osseous malformations in 11, spinal fractures in two, plasmacytoma in one, osteomyelitis in one, and a gunshot injury in one [5].

High impact information on Spinal Fractures

• Heparin-induced spinal fractures [6].
• Raloxifene reduces spinal fractures postmenopausally [7].
• OBJECTIVE: To test whether slow-release sodium fluoride inhibits spinal fractures and is safe to use [8].
• Spinal fractures complicating ankylosing spondylitis [9].
• Parathyroid hormone decreased the incidence of radiographically detected spinal fractures [10].

Chemical compound and disease context of Spinal Fractures

• Only 17% of fluoride-treated patients were nonresponders (new spinal fractures or a fall/no change in L2-L4 bone mass) [11].
• Concomitant medications (estrogen, vitamin D, thiazide and thyroid hormone) were not independent predictors of the spinal fracture risk [11].
• Only two studies specifically addressed the effects of calcitriol on spinal fracture rate [12].
• 25-Hydroxycholecalciferol and insulin-like growth factor I are determinants of serum concentration of osteocalcin in elderly subjects with and without spinal fractures [13].
• Surgical stabilization of cervical spinal fractures using methyl methacrylate. Technical considerations and long-term results in 52 patients [14].

Biological context of Spinal Fractures

• The spinal fracture rate decreased as a function of time on therapy (r = -0.83, p less than 0.01), and was inversely related to spinal bone density during fluoride therapy (r = 0.70, p less than 0.001 on arithmetic plot; r = -0.79, p less than 0.001 on semi-log plot) [15].
• Reviewer's comment regarding: "Sagittal range of motion after a spinal fracture; does ROM correlate with functional outcome?" (R.B. Post et al.) [16].

Anatomical context of Spinal Fractures

• Extradural hematoma, a recognized cause of spinal cord compression in ankylosing spondylitis patients with spinal fractures, was encountered in two patients [17].
• Frankel A or B were usually accompanied by either an unstable spinal fracture or by spinal canal stenosis at the C3/4 level [18].

Gene context of Spinal Fractures

• The relationship between susceptibility to osteoporotic spinal fracture and serum IGF-I, IGFBP-3, or -2 levels was examined by decade to exclude the influence of aging [19].
• Surgical therapy for patients with ankylosing spondylitis corrects angular deformities with spinal osteotomies, and stabilization for spinal fractures [20].
• Research and clinical patients did not differ in age, femoral BMD, or number of spinal fractures [21].
• METHODS: A retrospective review of spinal fractures from T11 to L5 treated since 1985 by posterior plate fixation showed that 56 patients (37 men and 19 women) with an average age of 34 years and a minimum follow-up of 2 years (average, 41 months) were available for review [22].
• A biomechanical study of thoracolumbar spinal fractures with bone in the canal. Part II. The effect of flexion angulation, distraction, and shortening of the motion segment [23].

Analytical, diagnostic and therapeutic context of Spinal Fractures

• Scintigraphy with 99mTc-phosphates is useful in the detection of spinal fracture and pseudoarthrosis in individuals with ankylosing spondylitis [24].

References