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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Pregnancy, parturition, and lactation in hypophyseal stalk-transected beef heifers.

Progesterone secretion is crucial for maintaining pregnancy to parturition in mammalian species, and in cattle the corpus luteum is the primary source of this hormone. This study determined the roles of prolactin ( PRL), growth hormone ( GH) and luteinizing hormone (LH) in the luteotropic process in beef heifers hypophyseal stalk-transected ( HST, n=7) or sham operated (sham operated controls, SOC, n=9) during midgestation. The main finding was that endogenous PRL and GH maintained progesterone secretion in HST heifers in a similar manner to that in SOC throughout pregnancy. Serum PRL averaged 37 vs 187 and GH 2 vs 4 ng/ml in HST heifers compared with SOC, whereas LH abruptly decreased to undetectable levels after HST compared with a modest 0.4 ng/ml in SOC heifers. The second finding was that parturition and lactation occurred in HST heifers with calf delivery induced to occur at the same time as SOC. Milk production in HST animals was severely limited, and postpartum estrus obliterated compared with SOC. The suckling stimulus sustained milk ejection in HST heifers in spite of diminished PRL, GH, thyroid stimulating hormone, thyroxine and tri-iodothyronine secretion. The results suggest that PRL, GH and possibly placental lactogen are luteotropic during pregnancy in cattle.[1]


  1. Pregnancy, parturition, and lactation in hypophyseal stalk-transected beef heifers. Anderson, L.L., Hard, D.L., Carpenter, L.S., Awotwi, E.K., Diekman, M.A., Trenkle, A.H., Cho, J. J. Endocrinol. (1999) [Pubmed]
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