- Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation. Jackson-Grusby, L., Beard, C., Possemato, R., Tudor, M., Fambrough, D., Csankovszki, G., Dausman, J., Lee, P., Wilson, C., Lander, E., Jaenisch, R. Nat. Genet. (2001)