Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Palli, D. et al.

Palli, Russo, Ottini, Masala, Saieva, Amorosi, Cama, D'Amico, Falchetti, Palmirotta, Decarli, Mariani Costantini, Fraumeni,

Red meat, family history, and increased risk of gastric cancer with microsatellite instability.

Microsatellite instability (MSI) occurs frequently in sporadic gastric cancer (GC) and may define a distinctive molecular pathway of carcinogenesis. We evaluated the role of dietary risk factors in GC according to MSI status. A large series of 382 GC cases and 561 controls were originally identified in a population-based case-control study carried out in the high-risk area around Florence, Italy; 126 GC patients were typed for MSI status. A MSI+ phenotype was detected in 43 of 126 cases (34.1%), whereas 83 cases were classified as MSI-. A multinomial logistic regression model was used to compare the two subgroups of GC classified according to MSI status in the same analysis, with all of the available population controls. A case-case approach was also used. The risk of MSI+ tumors was positively associated with high consumption of red meat and meat sauce and negatively associated with consumption of white meat. A positive association was also seen with total protein and nitrite intake, whereas no relation was found with micronutrient intake. Risk was especially high among subjects reporting both a positive GC family history and a high consumption of red meat (odds ratio, 25.7; 95% confidence interval, 6.4-102.8). For MSI- tumors, a significant protective effect was associated with frequent consumption of citrus and other fresh fruit, garlic, legumes, vegetables, and olive oil and with high intake of beta-carotene and other antioxidants and sugar, whereas positive associations were seen with protein and sodium intake. In summary, a specific dietary pattern emerged for MSI+ gastric tumors, suggesting that factors related to red meat consumption are involved in this pathway, particularly among individuals with a positive family history. In contrast, the risk of MSI- tumors was strongly reduced by the frequent consumption of fresh fruit and vegetables.[1]

References

Red meat, family history, and increased risk of gastric cancer with microsatellite instability. Palli, D., Russo, A., Ottini, L., Masala, G., Saieva, C., Amorosi, A., Cama, A., D'Amico, C., Falchetti, M., Palmirotta, R., Decarli, A., Mariani Costantini, R., Fraumeni, J.F. Cancer Res. (2001) [Pubmed]

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