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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Effect of interferon-alpha on tyrosine hydroxylase and catecholamine levels in the brain of rats.

We investigated the effect of interferon on tyrosine hydroxylase ( TH) and catecholamine levels in the brains of 12-week-old male Wistar rats. Interferon-alpha (300,000 IU/kg/day, s.c.) was administered to rats for 7 days. Locomotor activity of interferon-alpha-treated rats was significantly lower than that of control rats. Norepinephrine and dopamine levels and TH activities in the cerebral cortex, hypothalamus and medulla oblongata of interferon-alpha-treated rats were significantly higher than those of control rats. Norepinephrine and dopamine levels and TH activities in the thalamus and hippocampus were not different between interferon-alpha treated and control rats. These results suggest that interferon-alpha-induced depression may be related to change in the catecholamine synthetic pathway in the central nervous system.[1]

References

  1. Effect of interferon-alpha on tyrosine hydroxylase and catecholamine levels in the brain of rats. Kumai, T., Tateishi, T., Tanaka, M., Watanabe, M., Shimizu, H., Kobayashi, S. Life Sci. (2000) [Pubmed]
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