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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Albuminuria in people at least 40 years old: effect of obesity, hypertension, and hyperlipidemia.

Concentrations of urinary albumin and the albumin:creatinine ratio were measured in early-morning urine specimens from 5670 people older than 40 years who participated in a health screening survey of a local workforce. Sex-specific reference intervals were determined in a subgroup of 3597 people after excluding 2073 individuals with Albustix-positive proteinuria; diabetes mellitus; bacteriuria; current hypertension; body mass index greater than or equal to 30 kg/m2; or serum triglyceride greater than or equal to 2.5 mmol/L. The 97.5 percentile concentration for urinary albumin was 28 mg/L in men and 29 mg/L in women; for the albumin:creatinine ratio this was 2.3 g/ mol in men and 2.8 g/ mol in women. In the study population, the degree of albuminuria showed piecewise log-linear relationships with diastolic blood pressure (P = 0.0001) and body mass index (P = 0.0001), log-linear relationships with hypertriglyceridemia (P = 0.0001) and hypercholesterolemia (P = 0.0001), and a negative piecewise linear relationship with high-density lipoprotein (HDL) cholesterol (P = 0.0461).[1]


  1. Albuminuria in people at least 40 years old: effect of obesity, hypertension, and hyperlipidemia. Metcalf, P., Baker, J., Scott, A., Wild, C., Scragg, R., Dryson, E. Clin. Chem. (1992) [Pubmed]
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