The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

The Association of Obesity and Hyperandrogenemia during the Pubertal Transition in Girls: Obesity as a Potential Factor in the Genesis of Postpubertal Hyperandrogenism.

Context: Adolescent hyperandrogenemia is considered a forerunner of adult polycystic ovary syndrome, but its etiology remains uncertain. Objective: Our objective was to explore the hypothesis that peripubertal obesity is associated with hyperandrogenemia. Design and Setting: We performed a cross-sectional analysis of data obtained at General Clinical Research Centers. Subjects: Subjects were 41 obese [body mass index (BMI) for age, >/=95%] and 35 normal-weight (BMI for age, <95%) peripubertal girls. Intervention: We used pooled blood samples ( approximately 0500-0700 h; n = 64) while fasting or single morning (fasting) samples (n = 12). Main Outcome Measures: We assessed adiposity and androgen concentrations. Results: BMI correlated with total testosterone ( T) (r(s) = 0.59), SHBG (r(s) = -0.69), and free T (r(s) = 0.69); free T was three times as great in obese girls compared with normal-weight girls (P < 0.0001 for all). BMI correlated with insulin (r(s) = 0.52); both insulin and LH correlated with free T (r(s) = 0.45 and 0.44, respectively; P < 0.001 for all). When analyzing early pubertal girls (pubertal stages 1-3; n = 36) alone, BMI correlated with total T (r(s) = 0.65), SHBG (r(s) = -0.74), and free T (r(s) = 0.75); free T was five times as great in obese early-pubertal girls (P < 0.001 for all). BMI correlated with insulin (r(s) = 0.65), and insulin correlated with free T (r(s) = 0.63, P < 0.01 for both). BMI correlated with free T while simultaneously adjusting for age, pubertal stage, insulin, LH, and dehydroepiandrosterone sulfate. Conclusion: Peripubertal obesity is associated with marked hyperandrogenemia, which is especially pronounced in early puberty.[1]

References

  1. The Association of Obesity and Hyperandrogenemia during the Pubertal Transition in Girls: Obesity as a Potential Factor in the Genesis of Postpubertal Hyperandrogenism. McCartney, C.R., Prendergast, K.A., Chhabra, S., Eagleson, C.A., Yoo, R., Chang, R.J., Foster, C.M., Marshall, J.C. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
 
WikiGenes - Universities