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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The expression of the genes for entactin, laminin A, laminin B1 and laminin B2 in murine lens morphogenesis and eye development.

The temporal expression of the genes for the excellular matrix proteins entactin and the A, B1, and B2 chains of laminin was examined in the eye of the developing mouse embryo by in situ hybridization of their messenger RNAs. Entactin messenger RNA was found in abundance in specific cells. In the 25 somite embryo entactin message was synthesized by mesenchymal cells and, at later stages, by hyalocytes and lens cells in addition. The message was not detectable in corneal epithelium at embryonic stages E15 and E18.5 and at birth but was present in adjacent stromal cells. At the 28 and 38 somite stages, before pigment granules interfered with the detection of silver grains, no entactin message was detected in pigmented epithelial cells, in contrast to the messages for laminin B1 and B2. Entactin was not found in the neural epithelium at any time during development. The distribution of the laminin B1, B2 and A chain messenger RNAs was distinctly different from that of entactin. In particular, during the early stages of development B1 and B2 messages were synthesized by ectodermal, lens, corneal, pigment epithelial and hyaloid cells. In the older embryos cells in the ganglion layer of the retina synthesized B1 and B2 messages but undetectable amounts of entactin or the A chain messages. In general the A chain message was in lower abundance throughout development. The distribution of laminin and entactin messages suggested that the extracellular matrices, which contained both proteins, can be derived either from a single cell type or from the contributions of multiple cell types. The data demonstrate the complexity of extracellular matrix synthesis and assembly in the diverse structures of the developing eye where the temporal expression of specific molecules are tailored to the specific developmental requirements of particular structures.[1]


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