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Gene Review

Nid1  -  nidogen 1

Mus musculus

Synonyms: A630025O17, Ent, Entactin, NID-1, Nid, ...
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Disease relevance of Nid1


High impact information on Nid1


Chemical compound and disease context of Nid1


Biological context of Nid1


Anatomical context of Nid1


Associations of Nid1 with chemical compounds


Physical interactions of Nid1


Other interactions of Nid1


Analytical, diagnostic and therapeutic context of Nid1


  1. Neurologic defects and selective disruption of basement membranes in mice lacking entactin-1/nidogen-1. Dong, L., Chen, Y., Lewis, M., Hsieh, J.C., Reing, J., Chaillet, J.R., Howell, C.Y., Melhem, M., Inoue, S., Kuszak, J.R., DeGeest, K., Chung, A.E. Lab. Invest. (2002) [Pubmed]
  2. The expression of the genes for entactin, laminin A, laminin B1 and laminin B2 in murine lens morphogenesis and eye development. Dong, L.J., Chung, A.E. Differentiation (1991) [Pubmed]
  3. Beta 1 integrin is essential for teratoma growth and angiogenesis. Bloch, W., Forsberg, E., Lentini, S., Brakebusch, C., Martin, K., Krell, H.W., Weidle, U.H., Addicks, K., Fässler, R. J. Cell Biol. (1997) [Pubmed]
  4. Immunolocalization of entactin, a sulfated basement membrane component, in rodent tissues, and comparison with GP-2 (laminin). Bender, B.L., Jaffe, R., Carlin, B., Chung, A.E. Am. J. Pathol. (1981) [Pubmed]
  5. Loss of nidogen-1 and -2 results in syndactyly and changes in limb development. B??se, K., Nischt, R., Page, A., Bader, B.L., Paulsson, M., Smyth, N. J. Biol. Chem. (2006) [Pubmed]
  6. Structural basis for the high-affinity interaction of nidogen-1 with immunoglobulin-like domain 3 of perlecan. Kvansakul, M., Hopf, M., Ries, A., Timpl, R., Hohenester, E. EMBO J. (2001) [Pubmed]
  7. Absence of basement membranes after targeting the LAMC1 gene results in embryonic lethality due to failure of endoderm differentiation. Smyth, N., Vatansever, H.S., Murray, P., Meyer, M., Frie, C., Paulsson, M., Edgar, D. J. Cell Biol. (1999) [Pubmed]
  8. Recombinant entactin promotes mouse primary trophoblast cell adhesion and migration through the Arg-Gly-Asp (RGD) recognition sequence. Yelian, F.D., Edgeworth, N.A., Dong, L.J., Chung, A.E., Armant, D.R. J. Cell Biol. (1993) [Pubmed]
  9. Modulation of melanoma cell adhesion to basement membrane components by retinoic acid. Edward, M., Gold, J.A., MacKie, R.M. J. Cell. Sci. (1989) [Pubmed]
  10. Entactin immunoreactivity in immature and adult rat brain. Niquet, J., Represa, A. Brain Res. Dev. Brain Res. (1996) [Pubmed]
  11. Concurrent reduction in the sulfation of heparan sulfate and basement membrane assembly in a cell model system. Brauer, P.R., Keller, K.M., Keller, J.M. Development (1990) [Pubmed]
  12. Activity of FCE 22891 compared with cefuroxime axetil and cefixime in pulmonary and subcutaneous infections in mice. Rossi, R., Castellani, P., Younes, G., Della Bruna, C. J. Antimicrob. Chemother. (1989) [Pubmed]
  13. In-vitro and in-vivo antibacterial activities of E1040, a new cephalosporin with potent antipseudomonal activity. Hiruma, R., Otsuki, M., Tashima, M., Obana, Y., Nishino, T. J. Antimicrob. Chemother. (1990) [Pubmed]
  14. Crystal structure and mutational analysis of a perlecan-binding fragment of nidogen-1. Hopf, M., Göhring, W., Ries, A., Timpl, R., Hohenester, E. Nat. Struct. Biol. (2001) [Pubmed]
  15. Specific ablation of the nidogen-binding site in the laminin gamma1 chain interferes with kidney and lung development. Willem, M., Miosge, N., Halfter, W., Smyth, N., Jannetti, I., Burghart, E., Timpl, R., Mayer, U. Development (2002) [Pubmed]
  16. Differential regulation of fibulin, tenascin-C, and nidogen expression during wound healing of normal and glucocorticoid-treated mice. Fässler, R., Sasaki, T., Timpl, R., Chu, M.L., Werner, S. Exp. Cell Res. (1996) [Pubmed]
  17. Evidence of nidogen-2 compensation for nidogen-1 deficiency in transgenic mice. Miosge, N., Sasaki, T., Timpl, R. Matrix Biol. (2002) [Pubmed]
  18. Amino acid sequence of mouse nidogen, a multidomain basement membrane protein with binding activity for laminin, collagen IV and cells. Mann, K., Deutzmann, R., Aumailley, M., Timpl, R., Raimondi, L., Yamada, Y., Pan, T.C., Conway, D., Chu, M.L. EMBO J. (1989) [Pubmed]
  19. The absence of nidogen 1 does not affect murine basement membrane formation. Murshed, M., Smyth, N., Miosge, N., Karolat, J., Krieg, T., Paulsson, M., Nischt, R. Mol. Cell. Biol. (2000) [Pubmed]
  20. Basal lamina molecules are concentrated in myogenic regions of the mouse limb bud. Godfrey, E.W., Gradall, K.S. Anat. Embryol. (1998) [Pubmed]
  21. Importance of nidogen binding to laminin gamma1 for branching epithelial morphogenesis of the submandibular gland. Kadoya, Y., Salmivirta, K., Talts, J.F., Kadoya, K., Mayer, U., Timpl, R., Ekblom, P. Development (1997) [Pubmed]
  22. Identification of a novel form of the alpha 3 integrin subunit: covalent association with transferrin receptor. Coppolino, M., Migliorini, M., Argraves, W.S., Dedhar, S. Biochem. J. (1995) [Pubmed]
  23. Characterization of the 5' end of the mouse Ent gene encoding the basement membrane protein, entactin. Durkin, M.E., Liu, S.H., Reing, J., Chung, A.E. Gene (1993) [Pubmed]
  24. Purification and structural characterization of intact and fragmented nidogen obtained from a tumor basement membrane. Paulsson, M., Deutzmann, R., Dziadek, M., Nowack, H., Timpl, R., Weber, S., Engel, J. Eur. J. Biochem. (1986) [Pubmed]
  25. Role of mesenchymal nidogen for epithelial morphogenesis in vitro. Ekblom, P., Ekblom, M., Fecker, L., Klein, G., Zhang, H.Y., Kadoya, Y., Chu, M.L., Mayer, U., Timpl, R. Development (1994) [Pubmed]
  26. Gene structure and functional analysis of the mouse nidogen-2 gene: nidogen-2 is not essential for basement membrane formation in mice. Schymeinsky, J., Nedbal, S., Miosge, N., Pöschl, E., Rao, C., Beier, D.R., Skarnes, W.C., Timpl, R., Bader, B.L. Mol. Cell. Biol. (2002) [Pubmed]
  27. Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors. Baluk, P., Morikawa, S., Haskell, A., Mancuso, M., McDonald, D.M. Am. J. Pathol. (2003) [Pubmed]
  28. Positional cloning of the Chediak-Higashi syndrome gene: genetic mapping of the beige locus on mouse chromosome 13. Kingsmore, S.F., Barbosa, M.D., Tchernev, V.T., Detter, J.C., Lossie, A.C., Seldin, M.F., Holcombe, R.F. J. Investig. Med. (1996) [Pubmed]
  29. Hematopoietic Cells Are a Source of Nidogen-1 and Nidogen-2 during Mouse Liver Development. Tomte, L.T., Annatshah, Y., Schlüter, N.K., Miosge, N., Herken, R., Quondamatteo, F. J. Histochem. Cytochem. (2006) [Pubmed]
  30. Developmental changes in seminiferous tubule extracellular matrix components of the mouse testis: alpha 3(IV) collagen chain expressed at the initiation of spermatogenesis. Enders, G.C., Kahsai, T.Z., Lian, G., Funabiki, K., Killen, P.D., Hudson, B.G. Biol. Reprod. (1995) [Pubmed]
  31. Basement membrane proteins produced by Schwann cells and in neurofibromatosis. Dziadek, M., Edgar, D., Paulsson, M., Timpl, R., Fleischmajer, R. Ann. N. Y. Acad. Sci. (1986) [Pubmed]
  32. Hypoplastic basement membrane of the lens anlage in the inheritable lens aplastic mouse (lap mouse). Aso, S., Baba, R., Noda, S., Ikuno, S., Fujita, M. Teratology (2000) [Pubmed]
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