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Pongcharoen, S. et al.

Sutatip Pongcharoen, Pannika R. Niumsup, Donruedee Sanguansermsri,

JEG-3 cell culture supernatants cause reduced interferon-gamma and interleukin-17 production in mixed-lymphocyte reactions.

PROBLEM: Immunoregulatory effects of choriocarcinoma-derived factors on leukocytes have been documented. The present study was designed to investigate the effect of JEG-3 culture supernatants on interferon-gamma (IFN-gamma), interleukin-17 (IL-17) and IL-1beta production in the mixed lymphocyte reactions (MLRs). METHOD OF STUDY: A human choriocarcinoma cell line JEG-3 was used to test the effects of its culture supernatants on the proliferation and cytokine production in the MLRs. The cell proliferation was assessed using the BrdU incorporation and the amounts of cytokines were measured using enzyme-linked immunosorbent assays. RESULTS: The JEG-3 culture supernatants caused significantly reduced IFN-gamma and IL-17 production in the MLRs. However, the supernatants did not influence MLR production of IL-1beta. CONCLUSION: IFN-gamma and IL-17 are mainly produced by activated T cells but IL-1beta is primarily produced by monocytes, thus suggesting that immunoregulatory factors of JEG-3 cells selectively inhibit cytokine production by activated T cells rather than that of the monocytes.[1]

References

JEG-3 cell culture supernatants cause reduced interferon-gamma and interleukin-17 production in mixed-lymphocyte reactions. Pongcharoen, S., Niumsup, P.R., Sanguansermsri, D. Am. J. Reprod. Immunol. (2007) [Pubmed]

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