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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Wolgemuth, D.J. et al.

Differential expression of the mouse homeobox-containing gene Hox-1.4 during male germ cell differentiation and embryonic development.

Hox-1.4 is a mouse homeobox-containing gene (initially identified as HBT-1), whose expression appears to be testis-specific in the adult animal. Examination of Hox-1.4 transcripts in RNA from testes of mutant mice deficient in germ cells confirms that Hox-1.4 expression within the testis is germ cell-specific. Enriched populations of spermatogenic cells were used to localize the expression of Hox-1.4 specifically to germ cells that have entered into and progressed beyond the meiotic prophase stage of differentiation and to demonstrate the presence of two different size Hox-1.4 transcripts. Examination of RNA from teratocarcinoma cell cultures and mouse embryos at 10.5-16.5 days of gestation demonstrated the presence of several Hox-1.4 transcripts, which are larger than those present in germ cells. In the midgestation fetus, Hox-1.4 expression is most abundant in the spinal cord.[1]

References

Differential expression of the mouse homeobox-containing gene Hox-1.4 during male germ cell differentiation and embryonic development. Wolgemuth, D.J., Viviano, C.M., Gizang-Ginsberg, E., Frohman, M.A., Joyner, A.L., Martin, G.R. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]

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