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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Carcinogenicity of halogenated olefinic and aliphatic hydrocarbons in mice.

A series of 15 halogenated hydrocarbons of industrial and environmental importance were tested for carcinogenicity by chronic administration by one or more routes in Ha:ICR Swiss mice. Not all compounds were tested by the four routes of administration used. Allyl chloride, 1,2-dibromo-3-chloropropane, and vinylidene chloride were active as skin tumor initiators in the two-stage carcinogenesis assays; phorbol myristate acetate was used as a promoter. 1,2-Dibromoethane was the only compound that induced a significant incidence (p less than 0.05) of skin papillomas, skin carcinomas, and lung tumors by repeated skin application. 1,2-Dichloroethane, 1,1,2,2-tetrabromoethane, and 1,2-dibromo-3-chloropropane induced lung and/or stomach tumors by repeated skin application. Two compounds showed sarcomagenic activity by sc injection; they were cis-1,3-dichloropropene and 2-chloropropanal. By intragastric intubation, 1-chloropropene and 2-chloropropanal induced significant numbers of stomach tumors. Vehicle, no-treatment, and positive control groups were included in these tests. The following compounds were also tested by one or more of the four routes but were inactive by the criteria used; i.e., they showed P = 0.05 or greater than 0.05: trichloroethylene, tetrachloroethylene, hexachlorobutadiene, chloroacetaldehyde, 1-chloropropene oxide (cis and trans), and trichloroethylene oxide.[1]

References

  1. Carcinogenicity of halogenated olefinic and aliphatic hydrocarbons in mice. Van Duuren, B.L., Goldschmidt, B.M., Loewengart, G., Smith, A.C., Melchionne, S., Seldman, I., Roth, D. J. Natl. Cancer Inst. (1979) [Pubmed]
 
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