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Chemical Compound Review

CCRIS 622     1,1-dichloroethene

Synonyms: CHEMBL156455, ACMC-1CAKJ, NCI-C54262, AG-E-77294, CHEBI:34031, ...
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Disease relevance of Polyvinylidene chloride


High impact information on Polyvinylidene chloride


Chemical compound and disease context of Polyvinylidene chloride


Biological context of Polyvinylidene chloride


Anatomical context of Polyvinylidene chloride


Associations of Polyvinylidene chloride with other chemical compounds


Gene context of Polyvinylidene chloride


Analytical, diagnostic and therapeutic context of Polyvinylidene chloride


  1. Tissue-mediated mutagenicity of vinylidene chloride and 2-chlorobutadiene in Salmonella typhimurium. Bartsch, H., Malaveille, C., Montesano, R., Tomatis, L. Nature (1975) [Pubmed]
  2. Oral toxicity of 1,1-dichloroethylene in the rat: effects of sex, age, and fasting. Andersen, M.E., Jenkins, L.J. Environ. Health Perspect. (1977) [Pubmed]
  3. Long-term testing of vinylidene chloride and chloroprene for carcinogenicity in rats. Ponomarkov, V., Tomatis, L. Oncology (1980) [Pubmed]
  4. Oxidation of trichloroethylene, 1,1-dichloroethylene, and chloroform by toluene/o-xylene monooxygenase from Pseudomonas stutzeri OX1. Chauhan, S., Barbieri, P., Wood, T.K. Appl. Environ. Microbiol. (1998) [Pubmed]
  5. Modification of 1,1-dichloroethylene hepatotoxicity by hypothyroidism. Szabo, S., Jaeger, R.J., Moslen, M.T., Reynolds, E.S. Toxicol. Appl. Pharmacol. (1977) [Pubmed]
  6. Formation of glutathione conjugates by reactive metabolites of vinylidene chloride in microsomes and isolated hepatocytes. Liebler, D.C., Meredith, M.J., Guengerich, F.P. Cancer Res. (1985) [Pubmed]
  7. Histochemical and immunocytochemical evidence of early, selective bile canaliculi injury after 1,1-dichloroethylene in rats. Moslen, M.T., Dunsford, H.A., Karnasuta, C., Chieco, P., Kanz, M.F. Am. J. Pathol. (1989) [Pubmed]
  8. 1,1-Dichloroethylene-induced alterations in glutathione and covalent binding in murine lung: morphological, histochemical, and biochemical studies. Moussa, M., Forkert, P.G. J. Pathol. (1992) [Pubmed]
  9. S-(2-chloroacetyl)glutathione, a reactive glutathione thiol ester and a putative metabolite of 1,1-dichloroethylene. Liebler, D.C., Latwesen, D.G., Reeder, T.C. Biochemistry (1988) [Pubmed]
  10. Cometabolic degradation of chlorinated alkenes by alkene monooxygenase in a propylene-grown Xanthobacter strain. Ensign, S.A., Hyman, M.R., Arp, D.J. Appl. Environ. Microbiol. (1992) [Pubmed]
  11. Mutagenicity of vinyl chloride, vinylidene chloride and chloroprene in V79 Chinese hamster cells. Drevon, C., Kuroki, T. Mutat. Res. (1979) [Pubmed]
  12. Cytogenetic studies on 1,1-dichloroethylene and its two isomers in mammalian cells in vitro and in vivo. Sawada, M., Sofuni, T., Ishidate, M. Mutat. Res. (1987) [Pubmed]
  13. Effect of hypoxia on the metabolism and hepatotoxicity of carbon tetrachloride and vinylidene chloride in rats. Siegers, C.P., Horn, W., Younes, M. Acta pharmacologica et toxicologica. (1985) [Pubmed]
  14. Enhancement of 1,1-dichloroethylene toxicity by pretreatment of fasted male rats with 2,3-epoxypropan-1-ol. Andersen, M.E., Jones, R.A., Jenkins, L.J. Drug and chemical toxicology. (1977) [Pubmed]
  15. Interim results of two-year toxicological studies in rats of vinylidene chloride incorporated in the drinking water or administered by repeated inhalation. Rampy, L.W., Quast, J.F., Humiston, C.G., Balmer, M.F., Schwetz, B.A. Environ. Health Perspect. (1977) [Pubmed]
  16. In vitro biotransformation of 1,1-dichloroethylene by hepatic cytochrome P-450 2E1 in mice. Lee, R.P., Forkert, P.G. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  17. Pharmacokinetics of vinylidene chloride. Dedrick, R.L. Environ. Health Perspect. (1979) [Pubmed]
  18. Evidence that 1,1-dichloroethylene induces apoptotic cell death in murine liver. Martin, E.J., Forkert, P.G. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  19. Genetic activity of vinylidene chloride in yeast. Bronzetti, G., Bauer, C., Corsi, C., Leporini, C., Nieri, R., del Carratore, R. Mutat. Res. (1981) [Pubmed]
  20. Inhibition of liver-microsome calcium pump by in vivo administration of CCl4, CHCl3 and 1,1-dichloroethylene (vinylidene chloride). Moore, L. Biochem. Pharmacol. (1980) [Pubmed]
  21. 1,1-Dichloroethylene inhibition of liver endoplasmic reticulum calcium pump function. Moore, L. Biochem. Pharmacol. (1982) [Pubmed]
  22. Histochemical evidence that plasma and mitochondrial membranes are primary foci of hepatocellular injury caused by 1,1-dichloroethylene. Chieco, P., Moslen, M.T., Reynolds, E.S. Lab. Invest. (1982) [Pubmed]
  23. Recent findings on the carcinogenicity of chlorinated olefins. Maltoni, C. Environ. Health Perspect. (1977) [Pubmed]
  24. Cytosolic calcium after carbon tetrachloride, 1,1-dichloroethylene, and phenylephrine exposure. Studies in rat hepatocytes with phosphorylase a and quin2. Long, R.M., Moore, L. Biochem. Pharmacol. (1987) [Pubmed]
  25. Genetic effects of chlorinated ethylenes in the yeast Saccharomyces cerevisiae. Koch, R., Schlegelmilch, R., Wolf, H.U. Mutat. Res. (1988) [Pubmed]
  26. Phospholipase A2 activation and cell injury in isolated rat hepatocytes exposed to bromotrichloromethane, chloroform, and 1,1-dichloroethylene as compared to effects of carbon tetrachloride. Glende, E.A., Recknagel, R.O. Toxicol. Appl. Pharmacol. (1992) [Pubmed]
  27. Cytochrome P-450-dependent bioactivation of 1,1-dichloroethylene to a reactive epoxide in human lung and liver microsomes. Dowsley, T.F., Reid, K., Petsikas, D., Ulreich, J.B., Fisher, R.L., Forkert, P.G. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  28. Renal tumorigenicity of 1,1-dichloroethene in mice: the role of male-specific expression of cytochrome P450 2E1 in the renal bioactivation of 1,1-dichloroethene. Speerschneider, P., Dekant, W. Toxicol. Appl. Pharmacol. (1995) [Pubmed]
  29. Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes. Simmonds, A.C., Reilly, C.A., Baldwin, R.M., Ghanayem, B.I., Lanza, D.L., Yost, G.S., Collins, K.S., Forkert, P.G. Drug Metab. Dispos. (2004) [Pubmed]
  30. Selective induction of renal microsomal cytochrome P-450-linked monooxygenases by 1,1-dichloroethylene in mice. Krijgsheld, K.R., Gram, T.E. Biochem. Pharmacol. (1984) [Pubmed]
  31. Susceptibility of residential wells to VOC and nitrate contamination. Aelion, C.M., Conte, B.C. Environ. Sci. Technol. (2004) [Pubmed]
  32. Protection from 1,1-dichloroethylene-induced Clara cell injury by diallyl sulfone, a derivative of garlic. Forkert, P.G., Lee, R.P., Dowsley, T.F., Hong, J.Y., Ulreich, J.B. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  33. Metabolism and pharmacokinetic profile of vinylidene chloride in rats following oral administration. McKenna, M.J., Zempel, J.A., Madrid, E.O., Braun, W.H., Gehring, P.J. Toxicol. Appl. Pharmacol. (1978) [Pubmed]
  34. Formation of dioxins from combustion of polyvinylidene chloride in a well-controlled incinerator. Yasuhara, A., Katami, T., Shibamoto, T. Chemosphere (2006) [Pubmed]
  35. Factors for efficiency of the Salmonella/microsome mutagenicity assay. Malaveille, C., Planche, G., Bartsch, H. Chem. Biol. Interact. (1977) [Pubmed]
  36. Nephrotoxicity and covalent binding of 1,1-dichloroethylene in buthionine sulphoximine-treated mice. Brittebo, E.B., Darnerud, P.O., Eriksson, C., Brandt, I. Arch. Toxicol. (1993) [Pubmed]
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