Chemical Compound Review:
tripen 1,1,2,3,4,4-hexachlorobuta- 1,3-diene
Synonyms:
HCBD, HCDD, Dolen-pur, PubChem22647, CCRIS 326, ...
- Mutagenicity of hexachloro-1,3-butadiene and its S-conjugates in the Ames test--role of activation by the mercapturic acid pathway in its nephrocarcinogenicity. Vamvakas, S., Kordowich, F.J., Dekant, W., Neudecker, T., Henschler, D. Carcinogenesis (1988)
- Chronic toxicity and reproduction studies of hexachlorobutadiene in rats. Kociba, R.J., Schwetz, B.A., Keyes, D.G., Jersey, G.C., Ballard, J.J., Dittenber, D.A., Quast, J.F., Wade, C.E., Humiston, C.G. Environ. Health Perspect. (1977)
- Percutaneous toxicity of hexachlorobutadiene. Duprat, P., Gradiski, D. Acta pharmacologica et toxicologica. (1978)
- Urine laminin and kallikrein, markers of tubulointerstitial damage in experimental protein overload on pre-existing renal damage. Saw, S., Aw, T.C., Sinniah, R. Pathology. (2001)
- Human microsomal glutathione S-transferase. Its involvement in the conjugation of hexachlorobuta-1,3-diene with glutathione. McLellan, L.I., Wolf, C.R., Hayes, J.D. Biochem. J. (1989)
- Inhibition of rat kidney mitochondrial DNA, RNA and protein synthesis by halogenated cysteine S-conjugates. Banki, K., Anders, M.W. Carcinogenesis (1989)
- The sulfoxidation of the hexachlorobutadiene metabolite N-acetyl-S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine is catalyzed by human cytochrome P450 3A enzymes. Werner, M., Guo, Z., Birner, G., Dekant, W., Guengerich, F.P. Chem. Res. Toxicol. (1995)
- A mechanism of haloalkene-induced renal carcinogenesis. Dekant, W., Vamvakas, S., Koob, M., Köchling, A., Kanhai, W., Müller, D., Henschler, D. Environ. Health Perspect. (1990)
- The mechanism of pentachlorobutadienyl-glutathione nephrotoxicity studied with isolated rat renal epithelial cells. Jones, T.W., Wallin, A., Thor, H., Gerdes, R.G., Ormstad, K., Orrenius, S. Arch. Biochem. Biophys. (1986)
- Assessment of the relative hazard involved with airborne irritants with additional hepatotoxic or nephrotoxic properties in mice. De Ceaurriz, J., Gagnaire, F., Ban, M., Bonnet, P. Journal of applied toxicology : JAT. (1988)
- Nephrotoxicity: a rational approach to target cell injury in vitro in the kidney. Bach, P.H., Kwizera, E.N. Xenobiotica (1988)
- In vitro studies of mechanisms of cytotoxicity. Jones, T.W., Thor, H., Orrenius, S. Food Chem. Toxicol. (1986)
- Excretion pattern and metabolism of hexachlorobutadiene in rats. Evidence for metabolic activation by conjugation reactions. Reichert, D., Schütz, S., Metzler, M. Biochem. Pharmacol. (1985)
- Sex differences in hexachlorobutadiene biotransformation and nephrotoxicity. Birner, G., Werner, M., Ott, M.M., Dekant, W. Toxicol. Appl. Pharmacol. (1995)
- Biosynthesis and biliary excretion of S-conjugates of hexachlorobuta-1,3-diene in the perfused rat liver. Gietl, Y.S., Anders, M.W. Drug Metab. Dispos. (1991)
- Stable transfection of LLC-PK1 cells with human microsomal glutathione S-transferase gene increases haloalkene glutathione S-conjugate formation and cytotoxicity. Otieno, M.A., Anders, M.W. Biochem. Biophys. Res. Commun. (1997)
- Hexachloro-1,3-butadiene: toxicology, metabolism, and mechanisms of toxicity. Yang, R.S. Reviews of environmental contamination and toxicology. (1988)
- Cysteine conjugate beta-lyase of rat kidney cytosol: characterization, immunocytochemical localization, and correlation with hexachlorobutadiene nephrotoxicity. MacFarlane, M., Foster, J.R., Gibson, G.G., King, L.J., Lock, E.A. Toxicol. Appl. Pharmacol. (1989)
- Toxicity of S-pentachlorobutadienyl-L-cysteine studied with isolated rat renal cortical mitochondria. Wallin, A., Jones, T.W., Vercesi, A.E., Cotgreave, I., Ormstad, K., Orrenius, S. Arch. Biochem. Biophys. (1987)
- Development of newly formed nephrons in the goldfish kidney following hexachlorobutadiene-induced nephrotoxicity. Reimschuessel, R., Bennett, R.O., May, E.B., Lipsky, M.M. Toxicologic pathology. (1990)
- The formation of both a mono- and a bis-substituted glutathione conjugate of hexachlorobutadiene by isolated hepatocytes and following in vivo administration to the rat. Jones, T.W., Gerdes, R.G., Ormstad, K., Orrenius, S. Chem. Biol. Interact. (1985)
- Induction of morphological transformation and unscheduled DNA synthesis in Syrian hamster embryo fibroblasts by hexachlorobutadiene and its putative metabolite pentachlorobutenoic acid. Schiffmann, D., Reichert, D., Henschler, D. Cancer Lett. (1984)
- Intestinal absorption of S-(pentachlorobutadienyl)glutathione and S-(pentachlorobutadienyl)-L-cysteine, the glutathione and cysteine S-conjugates of hexachlorobuta-1,3-diene. Gietl, Y., Vamvakas, S., Anders, M.W. Drug Metab. Dispos. (1991)
- Acute and chronic effects of hexachlorobenzene and hexachlorobutadiene in red swamp crayfish (Procambarus clarki) and selected fish species. Laska, A.L., Bartell, C.K., Condie, D.B., Brown, J.W., Evans, R.L., Laseter, J.L. Toxicol. Appl. Pharmacol. (1978)
- Detection of reactive metabolites in vitro. Garle, M.J., Fry, J.R. Toxicology (1989)
- Biliary excretion of hexachloro-1,3-butadiene and its relevance to tissue uptake and renal excretion in male rats. Payan, J.P., Fabry, J.P., Beydon, D., de Ceaurriz, J. Journal of applied toxicology : JAT. (1991)
- Binding of hexachlorobutadiene to alpha 2u-globulin and its role in nephrotoxicity in rats. Pähler, A., Birner, G., Ott, M.M., Dekant, W. Toxicol. Appl. Pharmacol. (1997)
- The effect of haloalkene cysteine conjugates on rat renal glutathione reductase and lipoyl dehydrogenase activities. Lock, E.A., Schnellmann, R.G. Toxicol. Appl. Pharmacol. (1990)
- Mechanism of nephrotoxic action due to organohalogenated compounds. Lock, E.A. Toxicol. Lett. (1989)
- Hexachloro-1,3-butadiene-induced hydropic change in mouse liver. Lock, E.A., Pratt, I.S., Ishmael, J. Journal of applied toxicology : JAT. (1985)
- Segmentary effects on the renal proximal tubule due to hexachloro-1,3-butadiene in rats: biomarkers related to gender. Trevisan, A., Cristofori, P., Beggio, M., Venturini, M.B., Di Marco, L., Zanetti, E. Journal of applied toxicology : JAT. (2005)
- Intranephron distribution of cysteine S-conjugate beta-lyase activity and its implication for hexachloro-1,3-butadiene-induced nephrotoxicity in rats. Kim, H.S., Cha, S.H., Abraham, D.G., Cooper, A.J., Endou, H. Arch. Toxicol. (1997)
- Partial contribution of biliary metabolites to nephrotoxicity, renal content and excretion of [14C]hexachloro-1,3-butadiene in rats. Payan, J.P., Beydon, D., Fabry, J.P., Morel, G., Brondeau, M.T., Ban, M., De Ceaurriz, J. Journal of applied toxicology : JAT. (1993)
- An association between mutagenicity of the Ara test of Salmonella typhimurium and carcinogenicity in rodents for 16 halogenated aliphatic hydrocarbons. Roldán-Arjona, T., García-Pedrajas, M.D., Luque-Romero, F.L., Hera, C., Pueyo, C. Mutagenesis (1991)
- Determination of hexachloro-1,3-butadiene in spinach, eggs, fish, and milk by electron capture gas-liquid chromatography. Yurawecz, M.P., Dreifuss, P.A., Kamps, L.R. Journal - Association of Official Analytical Chemists. (1976)
- Concentrations of individual serum or plasma bile acids in workers exposed to chlorinated aliphatic hydrocarbons. Driscoll, T.R., Hamdan, H.H., Wang, G., Wright, P.F., Stacey, N.H. British journal of industrial medicine. (1992)