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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Barbiturate therapy in the postoperative endarterectomy patient with a neurologic deficit.

Three patients awoke in the operating theater with a neurologic deficit after carotid endarterectomy with shunt under general anesthesia with either upper or lower extremity paralysis or both and evidence of a patent carotid artery confirmed by Doppler ultrasonography, B-mode real-time ultrasonography, or surgery. After confirmation of patency of the carotid artery, patients were anesthetized with thiopental (3 to 4 mg/kg) for 48 hours, with respiratory maintenance by ventilator. The therapeutic effect of barbiturates was monitored by prevention of spontaneous respiration without hypotension. All patients awoke approximately 36 to 48 hours after discontinuing the thiopental without the previously noted postoperative neurologic deficit or any adverse neurologic sequelae. At last follow-up more than 1 year postoperatively they were asymptomatic. Results of this study indicate that patients who undergo carotid endarterectomy and awake with a neurologic deficit and a patent operated vessel should be considered for barbiturate induced coma as a therapeutic modality.[1]


  1. Barbiturate therapy in the postoperative endarterectomy patient with a neurologic deficit. Markowitz, I.P., Adinolfi, M.F., Kerstein, M.D. Am. J. Surg. (1984) [Pubmed]
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