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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Endarterectomy


High impact information on Endarterectomy

  • However, smokers had a significantly higher content of collagen in coronary endarterectomy specimens and the aorta and a higher content of cholesterol in the aorta than non-smokers [6].
  • The content of cholesterol or collagen relative to protein in the aorta or endarterectomy specimens did not correlate with serum total cholesterol, triglyceride, or high-density-lipoprotein cholesterol, nor were there any significant differences between samples from normotensive and hypertensive patients [6].
  • INTERVENTION: Eighty-three patients (90 endarterectomies) were randomly assigned to receive oral aspirin, 325 mg, plus dipyridamole, 75 mg, beginning 12 hours preoperatively, followed by a second dose administered within 8 hours after the operation, and given three times daily thereafter for 1 year [7].
  • METHODS AND RESULTS: To determine the cellular source and location of MMP-1 in human carotid atherosclerotic lesions, in situ hybridization and immunohistochemistry were performed on 20 endarterectomy specimens [8].
  • Red, fibrin-rich thrombi within the thromboendarterectomy specimens were lined with a single layer of endothelial cells exhibiting high levels of PAI-1 antigen [9].

Chemical compound and disease context of Endarterectomy


Biological context of Endarterectomy


Anatomical context of Endarterectomy


Associations of Endarterectomy with chemical compounds


Gene context of Endarterectomy

  • In atherosclerotic arteries, TFPI protein and mRNA were detected in three of six internal carotid plaques from patients undergoing endarterectomy, and mRNA alone was detected in one further specimen [29].
  • In PBMCs obtained from those patients the day of endarterectomy, NF-kappaB activation and FasL expression were significantly increased compared with healthy controls (1.5+/-0.1 versus 0.5+/-0.1 and 2.1+/-0.1 versus 1.2+/-0.1 arbitrary units, respectively; P<0.001) [30].
  • METHODS: The basal rate of PAI-1 release from cultured human adult endothelial cells was studied in both a well-plate-seeding model and after seeding onto human endarterectomy specimens [31].
  • RESULTS: The concentration of OPG and OPN within the proximal internal carotid (PIC) part of the endarterectomy specimen removed from symptomatic patients was elevated 2- and 4-fold, respectively [32].
  • Thus, we investigated the role of MBL in restenosis after eversion endarterectomy in patients with severe carotid atherosclerosis [33].

Analytical, diagnostic and therapeutic context of Endarterectomy


  1. A link between diabetes and atherosclerosis: Glucose regulates expression of CD36 at the level of translation. Griffin, E., Re, A., Hamel, N., Fu, C., Bush, H., McCaffrey, T., Asch, A.S. Nat. Med. (2001) [Pubmed]
  2. Low-dose and high-dose acetylsalicylic acid for patients undergoing carotid endarterectomy: a randomised controlled trial. ASA and Carotid Endarterectomy (ACE) Trial Collaborators. Taylor, D.W., Barnett, H.J., Haynes, R.B., Ferguson, G.G., Sackett, D.L., Thorpe, K.E., Simard, D., Silver, F.L., Hachinski, V., Clagett, G.P., Barnes, R., Spence, J.D. Lancet (1999) [Pubmed]
  3. Relation of plasma lipid and apoprotein levels to progressive intimal hyperplasia after arterial endarterectomy. Colyvas, N., Rapp, J.H., Phillips, N.R., Stoney, R., Perez, S., Kane, J.P., Havel, R.J. Circulation (1992) [Pubmed]
  4. Vasodilatory response of border zones to acetazolamide before and after endarterectomy : an echo planar imaging-dynamic susceptibility contrast-enhanced MRI study in patients with high-grade unilateral internal carotid artery stenosis. Wiart, M., Berthezène, Y., Adeleine, P., Feugier, P., Trouillas, P., Froment, J.C., Nighoghossian, N. Stroke (2000) [Pubmed]
  5. High-grade carotid stenosis detected before general surgery: is endarterectomy indicated? Ballotta, E. Neurology (2002) [Pubmed]
  6. Collagen content of atherosclerotic arteries is higher in smokers than in non-smokers. Ribeiro, P., Jadhav, A.V., Walesby, R., Trayner, I., Edmondson, S., Oakley, C.M., Thompson, G.R. Lancet (1983) [Pubmed]
  7. Failure of aspirin plus dipyridamole to prevent restenosis after carotid endarterectomy. Harker, L.A., Bernstein, E.F., Dilley, R.B., Scala, T.E., Sise, M.J., Hye, R.J., Otis, S.M., Roberts, R.S., Gent, M. Ann. Intern. Med. (1992) [Pubmed]
  8. Interstitial collagenase (MMP-1) expression in human carotid atherosclerosis. Nikkari, S.T., O'Brien, K.D., Ferguson, M., Hatsukami, T., Welgus, H.G., Alpers, C.E., Clowes, A.W. Circulation (1995) [Pubmed]
  9. Expression of type 1 plasminogen activator inhibitor in chronic pulmonary thromboemboli. Lang, I.M., Marsh, J.J., Olman, M.A., Moser, K.M., Loskutoff, D.J., Schleef, R.R. Circulation (1994) [Pubmed]
  10. Post-carotid endarterectomy hypertension: association with elevated cranial norepinephrine. Ahn, S.S., Marcus, D.R., Moore, W.S. J. Vasc. Surg. (1989) [Pubmed]
  11. Increasing levels of dietary homocystine with carotid endarterectomy produced proportionate increases in plasma homocysteine and intimal hyperplasia. Southern, F., Eidt, J., Drouilhet, J., Mukunyadzi, P., Williams, D.K., Cruz, C., Wang, Y.F., Poirier, L.A., Brown, A.T., Moursi, M.M. Atherosclerosis (2001) [Pubmed]
  12. Early versus delayed heparin reversal after carotid endarterectomy in the dog. A scanning electron microscopy study. Ercius, M.S., Chandler, W.F., Ford, J.W., Burkel, W.E. J. Neurosurg. (1983) [Pubmed]
  13. Continuous intravenous epoprostenol for chronic thromboembolic pulmonary hypertension. Bresser, P., Fedullo, P.F., Auger, W.R., Channick, R.N., Robbins, I.M., Kerr, K.M., Jamieson, S.W., Rubin, L.J. Eur. Respir. J. (2004) [Pubmed]
  14. Membrane diffusion and capillary blood volume in chronic thromboembolic pulmonary hypertension. Bernstein, R.J., Ford, R.L., Clausen, J.L., Moser, K.M. Chest (1996) [Pubmed]
  15. Incidence and mechanism of post-carotid endarterectomy hypertension. Skydell, J.L., Machleder, H.I., Baker, J.D., Busuttil, R.W., Moore, W.S. Archives of surgery (Chicago, Ill. : 1960) (1987) [Pubmed]
  16. Prostacyclin therapy before pulmonary thromboendarterectomy in patients with chronic thromboembolic pulmonary hypertension. Nagaya, N., Sasaki, N., Ando, M., Ogino, H., Sakamaki, F., Kyotani, S., Nakanishi, N. Chest (2003) [Pubmed]
  17. Lipid peroxidation and vitamin E in human coronary atherosclerotic lesions. Jacheć, W., Tomasik, A., Ceglarek, W., Woś, S., Wodniecki, J., Wojciechowska, C., Skrzep-Poloczek, B., Walichiewicz, P., Widenka, K. Clin. Chim. Acta (2003) [Pubmed]
  18. Indobufen versus placebo in the prevention of restenosis after carotid endarterectomy: a double-blind pilot study. Pratesi, C., Pulli, R., Milanesi, G., Lavezzari, M., Pamparana, F., Bertini, D. J. Int. Med. Res. (1991) [Pubmed]
  19. Oxidized low-density lipoprotein receptor LOX-1 and apoptosis in human atherosclerotic lesions. Li, D.Y., Chen, H.J., Staples, E.D., Ozaki, K., Annex, B., Singh, B.K., Vermani, R., Mehta, J.L. J. Cardiovasc. Pharmacol. Ther. (2002) [Pubmed]
  20. Laser endarterectomy: a comparison of thrombotic potential following CO2 laser vs surgical endarterectomy. McVicker, J.H., Day, A.L., Savage, D.F., Abela, G.S., Roberts, A.J., Watson, R.L., Mehta, J.L. Stroke (1986) [Pubmed]
  21. Is prosthetic renal artery reconstruction a durable procedure? An analysis of 489 bypass grafts. Paty, P.S., Darling, R.C., Lee, D., Chang, B.B., Roddy, S.P., Kreienberg, P.B., Lloyd, W.E., Shah, D.M. J. Vasc. Surg. (2001) [Pubmed]
  22. Fibrin glue containing fibroblast growth factor type 1 and heparin decreases platelet deposition. Zarge, J.I., Husak, V., Huang, P., Greisler, H.P. Am. J. Surg. (1997) [Pubmed]
  23. Biochemical assessment of myocardial injury after cardiac surgery: effects of a platelet activating factor antagonist, bilateral internal thoracic artery grafts, and coronary endarterectomy. Taggart, D.P. J. Thorac. Cardiovasc. Surg. (2000) [Pubmed]
  24. Intraoperative lidocaine injection into the carotid sinus during endarterectomy. Maher, C.O., Wetjen, N.M., Friedman, J.A., Meyer, F.B. J. Neurosurg. (2002) [Pubmed]
  25. Increased preferential absorption in human atherosclerotic plaque with oral beta carotene. Implications for laser endarterectomy. Prince, M.R., LaMuraglia, G.M., MacNichol, E.F. Circulation (1988) [Pubmed]
  26. The ubiquitin-proteasome system and inflammatory activity in diabetic atherosclerotic plaques: effects of rosiglitazone treatment. Marfella, R., D'Amico, M., Esposito, K., Baldi, A., Di Filippo, C., Siniscalchi, M., Sasso, F.C., Portoghese, M., Cirillo, F., Cacciapuoti, F., Carbonara, O., Crescenzi, B., Baldi, F., Ceriello, A., Nicoletti, G.F., D'Andrea, F., Verza, M., Coppola, L., Rossi, F., Giugliano, D. Diabetes (2006) [Pubmed]
  27. Comparison of ancrod and heparin as anticoagulants following endarterectomy in the dog. Daniel, T.M., Pizzo, S.V., Mckee, P.A. Ann. Surg. (1976) [Pubmed]
  28. Rotational endarterectomy in normal canine coronary arteries: preliminary report. Hansen, D.D., Auth, D.C., Hall, M., Ritchie, J.L. J. Am. Coll. Cardiol. (1988) [Pubmed]
  29. Tissue factor pathway inhibitor expression in atherosclerosis. Drew, A.F., Davenport, P., Apostolopoulos, J., Tipping, P.G. Lab. Invest. (1997) [Pubmed]
  30. NF-kappaB activation and Fas ligand overexpression in blood and plaques of patients with carotid atherosclerosis: potential implication in plaque instability. Martín-Ventura, J.L., Blanco-Colio, L.M., Muñoz-García, B., Gómez-Hernández, A., Arribas, A., Ortega, L., Tuñón, J., Egido, J. Stroke (2004) [Pubmed]
  31. Production of plasminogen activator inhibitor-1 by human saphenous vein endothelial cells seeded onto endarterectomy surfaces in vitro. Smyth, J.V., Rooney, O.B., Dodd, P.D., Walker, M.G. J. Vasc. Surg. (1997) [Pubmed]
  32. Osteoprotegerin and osteopontin are expressed at high concentrations within symptomatic carotid atherosclerosis. Golledge, J., McCann, M., Mangan, S., Lam, A., Karan, M. Stroke (2004) [Pubmed]
  33. High rate of early restenosis after carotid eversion endarterectomy in homozygous carriers of the normal mannose-binding lectin genotype. Rugonfalvi-Kiss, S., Dósa, E., Madsen, H.O., Endrész, V., Prohászka, Z., Laki, J., Karádi, I., Gönczöl, E., Selmeci, L., Romics, L., Füst, G., Entz, L., Garred, P. Stroke (2005) [Pubmed]
  34. Folate supplementation inhibits intimal hyperplasia induced by a high-homocysteine diet in a rat carotid endarterectomy model. Smith, T.P., Cruz, C.P., Brown, A.T., Eidt, J.F., Moursi, M.M. J. Vasc. Surg. (2001) [Pubmed]
  35. Fluid flow decreases preproendothelin mRNA levels and suppresses endothelin-1 peptide release in cultured human endothelial cells. Sharefkin, J.B., Diamond, S.L., Eskin, S.G., McIntire, L.V., Dieffenbach, C.W. J. Vasc. Surg. (1991) [Pubmed]
  36. Differences in reendothelialization after balloon catheter removal of endothelial cells, superficial endarterectomy, and deep endarterectomy. Goff, S.G., Wu, H.D., Sauvage, L.R., Usui, Y., Wechezak, A.R., Coan, D.E., Arnell, R.E., Walker, M.W. J. Vasc. Surg. (1988) [Pubmed]
  37. Carotid bruit as a risk factor in aortoiliac reconstruction. Carney, W.I., Stewart, W.B., DePinto, D.J., Mucha, S.J., Roberts, B. Surgery (1977) [Pubmed]
  38. The argon contact laser scalpel: a study of its effect on atherosclerosis. Kim, L.Y., Day, A.L., Normann, S.J., Abela, G.S., Mehta, J.L. Neurosurgery (1987) [Pubmed]
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