The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Central cardiovascular effects of taurine: comparison with homotaurine and muscimol.

The central cardiovascular effects of taurine were compared with those of homotaurine and muscimol. The drugs were injected i.c.v. in cumulative doses into pentobarbital-anesthetized cats. Muscimol (0.1-30 microgram/kg) produced dose-dependent hypotension and bradycardia, with a maximum effect of 70 +/- 5 mm Hg and 75 +/- 5 beats/min, respectively. Homotaurine led to a dose-related fall in blood pressure and heart rate; maximum effects were obtained with 300 microgram/kg and averaged 55 +/- 3 mm Hg and 73 +/- 3 beats/min. For both drugs, the dose-response curves were shifted to the right by pretreatment with 10 microgram/kg of bicuculline i.c.v. This antagonism confirms that the central cardiovascular effects of muscimol and homotaurine are mediated by a stimulation of gamma-aminobutyric acid receptors. Taurine produced dose-related hypotension and bradycardia. The depressive effects of taurine started at a dose of 10 microgram/kg; at a dose of 1000 microgram/kg, the maximum effects observed were a 55 +/- 7 mm Hg hypotension and a 53 +/- 8 beats/min bradycardia. These effects were not affected by bicuculline pretreatment, but strychnine (i.c.v) prevented the effects of taurine. These findings indicate that glycine-type receptors may be involved in the taurine effects rather than gamma-aminobutyric acid type receptors. However, these results do not exclude the involvement of taurine-type receptors for which the specific antagonists is not yet available.[1]


  1. Central cardiovascular effects of taurine: comparison with homotaurine and muscimol. Bousquet, P., Feldman, J., Bloch, R., Schwartz, J. J. Pharmacol. Exp. Ther. (1981) [Pubmed]
WikiGenes - Universities