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Chemical Compound Review

Alzhemed     3-aminopropane-1-sulfonic acid

Synonyms: Cerebril, Homotaurine, Tramiprosat, Tramiprosate, PubChem18251, ...
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Analytical, diagnostic and therapeutic context of NC-758

  • Role of K+ -channels in homotaurine-induced analgesia [19].
  • The results have been compared with a control group of 36 rats that received water during the treatment phase of the experiment, and the 14th day received intraperitoneal muscimol or homotaurine [5].
  • CGP 35348 (50-200 mg/kg IP), a highly selective GABA(B) antagonist, was administered prior to carrying out a dose-response curve of homotaurine (22.6-445 mg/kg IP) antinociceptive effect in the abdominal constriction (mice) and tail flick (rats) tests [20].
  • Promising findings for the efficacy of tramiprosate, indicated by improvement or stabilization of cognitive function, have been shown in phase II clinical trials and open-label extensions of these studies [7].
  • Uptake, autoradiography and release of taurine and homotaurine from retinal tissue [21].


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  2. Homotaurine and muscimol mimic taurine and GABA effects on muscle tone and temperature regulation. Sgaragli, G.P., Carlà, V., Magnani, M., Giotti, A. Naunyn Schmiedebergs Arch. Pharmacol. (1978) [Pubmed]
  3. Cardiovascular and ventilatory effects of taurine and homotaurine in anaesthetized rats. Paakkari, P., Paakkari, I., Karppanen, H., Halmekoski, J., Paasonen, M.K. Med. Biol. (1982) [Pubmed]
  4. Baclofen induces catatonia in rats. Mehta, A.K., Ticku, M.K. Neuropharmacology (1987) [Pubmed]
  5. Effects of muscimol or homotaurine on sleep-wake states in alcohol-dependent rats during withdrawal. Rouhani, S., Dall'Ava-Santucci, J., Bajenaru, O., Emmanouilidis, E., Tran, G., Manicom, R., Dinh-Xuan, A.T., Poenaru, S. Pharmacol. Biochem. Behav. (1998) [Pubmed]
  6. Anti-conflict and depressant effects by GABA agonists and antagonists, benzodiazepines and non-gabergic anticonvulsants on self-stimulation and locomotor activity. Herberg, L.J., Williams, S.F. Pharmacol. Biochem. Behav. (1983) [Pubmed]
  7. Tramiprosate. Wright, T.M. Drugs of today (Barcelona, Spain : 1998) (2006) [Pubmed]
  8. Characterization of gamma-aminobutyric acid receptors in the neurointermediate lobe of the amphibian Xenopus laevis. Verburg-van Kemenade, B.M., Jenks, B.G., Lenssen, F.J., Vaudry, H. Endocrinology (1987) [Pubmed]
  9. Involvement of noradrenaline in potentiation of the head-twitch response by GABA-related drugs. Singh, L., Heaton, J.C., Rea, P.J., Handley, S.L. Psychopharmacology (Berl.) (1986) [Pubmed]
  10. Baclofen activates two distinct receptors in the rat spinal cord and guinea pig ileum. Sawynok, J. Neuropharmacology (1986) [Pubmed]
  11. Homotaurine: a GABAB antagonist in guinea-pig ileum. Giotti, A., Luzzi, S., Spagnesi, S., Zilletti, L. Br. J. Pharmacol. (1983) [Pubmed]
  12. Neuropharmacological characterization of a taurine antagonist. Yarbrough, G.G., Singh, D.K., Taylor, D.A. J. Pharmacol. Exp. Ther. (1981) [Pubmed]
  13. Central cardiovascular effects of taurine: comparison with homotaurine and muscimol. Bousquet, P., Feldman, J., Bloch, R., Schwartz, J. J. Pharmacol. Exp. Ther. (1981) [Pubmed]
  14. Effects of omega-aminosulfonic acids on lipid metabolism in dietary hyperlipidemic rats. Yamada, J., Masuda, M., Tanaka, M., Horisaka, K. J. Pharmacobio-dyn. (1983) [Pubmed]
  15. GABA-mediated potentiation of amine release from nigrostriatal dopamine neurones in vitro. Starr, M.S. Eur. J. Pharmacol. (1979) [Pubmed]
  16. Cyclic amidine analogues of taurine and homotaurine: synthesis and effects on rat skeletal muscle. Campagna, F., Carotti, A., Casini, G., Palluotto, F., Pierno, S., Tricarico, D., De Luca, A., Conte-Camerino, D. Farmaco (1994) [Pubmed]
  17. The development of anti-amyloid therapy for Alzheimer's disease : from secretase modulators to polymerisation inhibitors. Aisen, P.S. CNS drugs. (2005) [Pubmed]
  18. Effects of intraventricular taurine, homotaurine and GABA on serum prolactin and thyrotropin levels in female and in male rats. Mäkinen, M., Ahtee, L., Rosenqvist, K., Tuominen, R.K., Männistö, P. J. Neural Transm. Gen. Sect. (1993) [Pubmed]
  19. Role of K+ -channels in homotaurine-induced analgesia. Serrano, M.I., Serrano, J.S., Asadi, I., Fernández, A., Serrano-Martino, M.C. Fundamental & clinical pharmacology. (2001) [Pubmed]
  20. GABA(B) receptors and opioid mechanisms involved in homotaurine-induced analgesia. Serrano, M.I., Serrano, J.S., Fernández, A., Asadi, I., Serrano-Martino, M.C. Gen. Pharmacol. (1998) [Pubmed]
  21. Uptake, autoradiography and release of taurine and homotaurine from retinal tissue. Schulze, E., Neuhoff, V. Int. J. Neurosci. (1983) [Pubmed]
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