Effects of horminone on liver mixed function mono-oxygenases and glutathione enzyme activities of Wistar rat.
The present study reports on the effects of horminone on serum alanine aminotransferase ( ALT) and aspartate aminotransferase (AST) levels, on hepatic cytochrome P450 (P450) and cytochrome b5 (cyt b5) contents and on the activities of NADPH-cytochrome P450 reductase (NR), mixed function mono-oxygenases (MFO), glutathione-S-transferase ( GST) and glutathione reductase ( GR) of Wistar male rat. Horminone is a diterpenoid quinone (7,12-dihydroxyabiet-8,12-diene-11,14-dione) present in several species of the Labiatae family and used as medicinal plants in folk medicine. In this study, horminone was administered by the intraperitoneal route (i.p.) at a concentration of 1 or 10 mg/kg to each group of six mice, using water as a vehicle. On the one hand, results showed that horminone increased serum ALT and AST levels and cyt b5 content and induced the activities of ethylmorphine N-demethylase (EMD). On the other hand, horminone decreased P450 content and inhibited the activities of 7-ethoxyresorufin O-deethylase (ERD), 7-ethoxycoumarin O-deethylase (ECD), aniline 4-hydroxylase (AH) and NR. Based on these results, the possibility of toxic effects occurring after administration of plant extracts containing horminone must be considered.[1]References
- Effects of horminone on liver mixed function mono-oxygenases and glutathione enzyme activities of Wistar rat. Ferreira, R., Candeias, F., Simões, F., Nascimento, J., Cruz Morais, J. Journal of ethnopharmacology. (1997) [Pubmed]
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