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Chemical Compound Review

ETHOXYCOUMARIN     7-ethoxychromen-2-one

Synonyms: PubChem8680, CHEMBL191528, AG-F-02897, ACMC-209hjx, CHEBI:28184, ...
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Disease relevance of C11052


High impact information on C11052


Chemical compound and disease context of C11052


Biological context of C11052


Anatomical context of C11052

  • There are only minimal activities that can be found in substantial quantities in placentas without maternal smoking; one example is 7-ethoxycoumarin O-deethylase (ECOD) [16].
  • PICM-19 P-450 activity induced by 7-ethoxycoumarin was nearly equivalent to that of primary cultures of pig hepatocytes [17].
  • These data indicate that mitochondria supply 50 to 70% of the reducing equivalents for mixed function oxidation of 7-ethoxycoumarin in both regions of the liver lobule in livers from fed rats [18].
  • To investigate the drug-metabolizing potential of different sub-populations of cells along the villus-crypt surface of the small intestine, the major monooxygenase activities directed towards the substrates benzo[a]pyrene (BP), 7-ethoxycoumarin and ethylmorphine were studied [19].
  • The activities of aryl hydrocarbon hydroxylase and 7-ethoxycoumarin O-de-ethylase in the rat submandibular gland, both of which are normally very low, were increased about 10- and 25-fold, respectively, by administration of 3-methylcholanthrene [20].

Associations of C11052 with other chemical compounds


Gene context of C11052


Analytical, diagnostic and therapeutic context of C11052


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  31. Molecular cloning and functional expression in yeast of CYP76B1, a xenobiotic-inducible 7-ethoxycoumarin O-de-ethylase from Helianthus tuberosus. Batard, Y., LeRet, M., Schalk, M., Robineau, T., Durst, F., Werck-Reichhart, D. Plant J. (1998) [Pubmed]
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