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Chemical Compound Review

ETHOXYCOUMARIN     7-ethoxychromen-2-one

Synonyms: PubChem8680, CHEMBL191528, AG-F-02897, ACMC-209hjx, CHEBI:28184, ...
 
 
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Disease relevance of C11052

 

High impact information on C11052

 

Chemical compound and disease context of C11052

 

Biological context of C11052

 

Anatomical context of C11052

  • There are only minimal activities that can be found in substantial quantities in placentas without maternal smoking; one example is 7-ethoxycoumarin O-deethylase (ECOD) [16].
  • PICM-19 P-450 activity induced by 7-ethoxycoumarin was nearly equivalent to that of primary cultures of pig hepatocytes [17].
  • These data indicate that mitochondria supply 50 to 70% of the reducing equivalents for mixed function oxidation of 7-ethoxycoumarin in both regions of the liver lobule in livers from fed rats [18].
  • To investigate the drug-metabolizing potential of different sub-populations of cells along the villus-crypt surface of the small intestine, the major monooxygenase activities directed towards the substrates benzo[a]pyrene (BP), 7-ethoxycoumarin and ethylmorphine were studied [19].
  • The activities of aryl hydrocarbon hydroxylase and 7-ethoxycoumarin O-de-ethylase in the rat submandibular gland, both of which are normally very low, were increased about 10- and 25-fold, respectively, by administration of 3-methylcholanthrene [20].
 

Associations of C11052 with other chemical compounds

 

Gene context of C11052

 

Analytical, diagnostic and therapeutic context of C11052

References

  1. Monooxygenase enzyme activity in alcoholics with varying degrees of liver damage. Hoensch, H., Hartmann, F., Schomerus, H., Bieck, P., Dölle, W. Gut (1979) [Pubmed]
  2. Altered patterns of cutaneous xenobiotic metabolism in UVB-induced squamous cell carcinoma in SKH-1 hairless mice. Das, M., Bickers, D.R., Santella, R.M., Mukhtar, H. J. Invest. Dermatol. (1985) [Pubmed]
  3. Identification of a new class of cytochrome P450 from a Rhodococcus sp. Roberts, G.A., Grogan, G., Greter, A., Flitsch, S.L., Turner, N.J. J. Bacteriol. (2002) [Pubmed]
  4. The effect of alcoholic cirrhosis on the activities of microsomal aldrin epoxidase, 7-ethoxycoumarin O-de-ethylase and epoxide hydrolase, and on the concentrations of reduced glutathione in human liver. Woodhouse, K.W., Williams, F.M., Mutch, E., Wright, P., James, O.F., Rawlins, M.D. British journal of clinical pharmacology. (1983) [Pubmed]
  5. The metabolism of 7-ethoxycoumarin in human liver microsomes and the effect of primary biliary cirrhosis: implications for studies of drug metabolism in liver disease. Woodhouse, K.W., Mitchison, H.C., Mutch, E., Wright, P.D., Rawlins, M.D., James, O.F. British journal of clinical pharmacology. (1985) [Pubmed]
  6. Omeprazole inhibits oxidative drug metabolism. Studies with diazepam and phenytoin in vivo and 7-ethoxycoumarin in vitro. Gugler, R., Jensen, J.C. Gastroenterology (1985) [Pubmed]
  7. Purification and characterization of cytochrome P-450 induced by benz(a)anthracene in mouse skin microsomes. Ichikawa, T., Hayashi, S., Noshiro, M., Takada, K., Okuda, K. Cancer Res. (1989) [Pubmed]
  8. Xenobiotic metabolism in human alveolar type II cells isolated by centrifugal elutriation and density gradient centrifugation. Devereux, T.R., Massey, T.E., Van Scott, M.R., Yankaskas, J., Fouts, J.R. Cancer Res. (1986) [Pubmed]
  9. Monoclonal antibody phenotyping of interindividual differences in cytochrome P-450-dependent reactions of single and twin human placenta. Fujino, T., Gottlieb, K., Manchester, D.K., Park, S.S., West, D., Gurtoo, H.L., Tarone, R.E., Gelboin, H.V. Cancer Res. (1984) [Pubmed]
  10. Antipyrine elimination and hepatic microsomal enzyme activity in patients with liver disease. Wensing, G., Ohnhaus, E.E., Hoensch, H.P. Clin. Pharmacol. Ther. (1990) [Pubmed]
  11. Modulation of benzene-induced lymphocytopenia in the rat by 2,4,5,2',4',5'-hexachlorobiphenyl and 3,4,3',4'-tetrachlorobiphenyl. Greenlee, W.F., Irons, R.D. Chem. Biol. Interact. (1981) [Pubmed]
  12. Cytochrome P-450-dependent xenobiotic metabolizing activity in Zymbal's gland, a specialized sebaceous gland of rodents. Pohl, R.J., Fouts, J.R. Cancer Res. (1983) [Pubmed]
  13. Kinetic isotope effects on cytochrome P-450-catalyzed oxidation reactions. Evidence for the irreversible formation of an activated oxygen intermediate of cytochrome P-448. Harada, N., Miwa, G.T., Walsh, J.S., Lu, A.Y. J. Biol. Chem. (1984) [Pubmed]
  14. Interactions between glycolysis and mixed function oxidation: studies with 7-ethoxycoumarin in perfused livers from beta-naphthoflavone-treated rats. Belinsky, S.A., Kauffman, F.C., Thurman, R.G. Mol. Pharmacol. (1989) [Pubmed]
  15. Diverse functions of aromatase: O-deethylation of 7-ethoxycoumarin. Toma, Y., Higashiyama, T., Yarborough, C., Osawa, Y. Endocrinology (1996) [Pubmed]
  16. The expression and environmental regulation of P450 enzymes in human placenta. Pasanen, M., Pelkonen, O. Crit. Rev. Toxicol. (1994) [Pubmed]
  17. Ultrastructure, enzymatic, and transport properties of the PICM-19 bipotent liver cell line. Talbot, N.C., Caperna, T.J., Lebow, L.T., Moscioni, D., Pursel, V.G., Rexroad, C.E. Exp. Cell Res. (1996) [Pubmed]
  18. Reducing equivalents for mixed function oxidation in periportal and pericentral regions of the liver lobule in perfused livers from normal and phenobarbital-treated rats. Belinsky, S.A., Kauffman, F.C., Thurman, R.G. Mol. Pharmacol. (1984) [Pubmed]
  19. Localization and characterization of drug-metabolizing enzymes along the villus-crypt surface of the rat small intestine--I. Monooxygenases. Dubey, R.K., Singh, J. Biochem. Pharmacol. (1988) [Pubmed]
  20. Aryl hydrocarbon hydroxylase activity in rat submandibular glands. Murakami, K., Ishikawa, T., Shimosato, T., Noshiro, M., Hayashi, S., Okuda, K. J. Dent. Res. (1986) [Pubmed]
  21. The rabbit pulmonary monooxygenase system. Immunochemical and biochemical characterization of enzyme components. Serabjit-Singh, C.J., Wolf, C.R., Philpot, R.M. J. Biol. Chem. (1979) [Pubmed]
  22. Purification and characterization of cholesterol 7 alpha-hydroxylase from rat liver microsomes. Ogishima, T., Deguchi, S., Okuda, K. J. Biol. Chem. (1987) [Pubmed]
  23. Site-directed mutagenesis of putative substrate recognition sites in cytochrome P450 2B11: importance of amino acid residues 114, 290, and 363 for substrate specificity. Hasler, J.A., Harlow, G.R., Szklarz, G.D., John, G.H., Kedzie, K.M., Burnett, V.L., He, Y.A., Kaminsky, L.S., Halpert, J.R. Mol. Pharmacol. (1994) [Pubmed]
  24. Effect of beta-naphthoflavone on mitochondrial supply of reducing equivalents for monooxygenation in periportal and pericentral regions of the liver lobule. Belinsky, S.A., Kari, F.W., Kauffman, F.C., Thurman, R.G. Mol. Pharmacol. (1987) [Pubmed]
  25. Mechanism of maintenance of liver-specific functions by DMSO in cultured rat hepatocytes. Villa, P., Arioli, P., Guaitani, A. Exp. Cell Res. (1991) [Pubmed]
  26. An inhibitory monoclonal antibody to human cytochrome P450 2A6 defines its role in the metabolism of coumarin, 7-ethoxycoumarin and 4-nitroanisole in human liver. Sai, Y., Yang, T.J., Krausz, K.W., Gonzalez, F.J., Gelboin, H.V. Pharmacogenetics (1999) [Pubmed]
  27. Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta. Hakkola, J., Pasanen, M., Hukkanen, J., Pelkonen, O., Mäenpää, J., Edwards, R.J., Boobis, A.R., Raunio, H. Biochem. Pharmacol. (1996) [Pubmed]
  28. Stable expression of human CYP2E1 in Chinese hamster cells: high sensitivity to N,N-dimethylnitrosamine in cytotoxicity testing. Nakagawa, T., Sawada, M., Gonzalez, F.J., Yokoi, T., Kamataki, T. Mutat. Res. (1996) [Pubmed]
  29. Oxidation of xenobiotics by recombinant human cytochrome P450 1B1. Shimada, T., Gillam, E.M., Sutter, T.R., Strickland, P.T., Guengerich, F.P., Yamazaki, H. Drug Metab. Dispos. (1997) [Pubmed]
  30. Prediction of human liver microsomal oxidations of 7-ethoxycoumarin and chlorzoxazone with kinetic parameters of recombinant cytochrome P-450 enzymes. Shimada, T., Tsumura, F., Yamazaki, H. Drug Metab. Dispos. (1999) [Pubmed]
  31. Molecular cloning and functional expression in yeast of CYP76B1, a xenobiotic-inducible 7-ethoxycoumarin O-de-ethylase from Helianthus tuberosus. Batard, Y., LeRet, M., Schalk, M., Robineau, T., Durst, F., Werck-Reichhart, D. Plant J. (1998) [Pubmed]
  32. Olfactory cytochrome P-450. Studies with suicide substrates of the haemoprotein. Reed, C.J., Lock, E.A., De Matteis, F. Biochem. J. (1988) [Pubmed]
  33. Site-directed mutageneses of rat liver cytochrome P-450d: catalytic activities toward benzphetamine and 7-ethoxycoumarin. Furuya, H., Shimizu, T., Hirano, K., Hatano, M., Fujii-Kuriyama, Y., Raag, R., Poulos, T.L. Biochemistry (1989) [Pubmed]
  34. Heterologous expression of rat P450 2E1 in a mammalian cell line: in situ metabolism and cytotoxicity of N-nitrosodimethylamine. Lin, H.L., Roberts, E.S., Hollenberg, P.F. Carcinogenesis (1998) [Pubmed]
 
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