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Chemical Compound Review:

HORMINON 1,10-dihydroxy-4b,8,8- trimethyl-2-propan-2...

Synonyms: Horminone, TAXOQUINONE, NSC-122418, NSC-294577, NSC122418, ...

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Disease relevance of Horminone

Horminone was also found to be active against Enterococcus faecalis ATCC 29212 [1].
Potent antibacterial activity was exhibited by the known compounds horminone (9) and 7-acetylhorminone (10) against Staphylococcus aureus ATCC 6538 P, Staphylococcus epidermidis ATCC 12226, and Bacillus subtilis ATCC 6633 [1].

High impact information on Horminone

Indeed, horminone, bonded to [Mg(H(2)O)(4)](2+), is able to cross the bacterial membrane cell [2].
Eight diterpenoids, trilobinol ( 1), trilobinone ( 2), ferruginol, horminone, 7alpha-acetylroyleanone, 6beta-hydroxyroyleanone, virgatol and cryptanol were isolated from the roots of SALVIA TRILOBA L. fil [3].
Two naphthoquinone diterpenoids, 1 and 2, one tricyclic, and one tetracyclic rearranged abietane ('4,5-seco-10,5-friedo-abietane') diterpenoids, 3 and 4, respectively, together with horminone (5) have been isolated from the roots of Salvia sahendica [4].
On the one hand, results showed that horminone increased serum ALT and AST levels and cyt b5 content and induced the activities of ethylmorphine N-demethylase (EMD) [5].
Horminone is a diterpenoid quinone (7,12-dihydroxyabiet-8,12-diene-11,14-dione) present in several species of the Labiatae family and used as medicinal plants in folk medicine [5].

Associations of Horminone with other chemical compounds

Tingenone and horminone, two natural quinonoid substances, inhibited the in vitro growth of Trypanosoma cruzi, 30 microM drug concentration producing total inhibition of growth [6].

References

Antibacterial diterpenes from the roots of Salvia blepharochlaena. Ulubelen, A., Oksüz, S., Topcu, G., Gören, A.C., Voelter, W. J. Nat. Prod. (2001) [Pubmed]
Theoretical study of the complexes of horminone with Mg2+ and Ca2+ ions and their relation with the bacteriostatic activity. Nicolás, I., Castro, M. The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory. (2006) [Pubmed]
New Diterpenoids from the Roots of Salvia triloba. Ulubelen, A. Planta Med. (1990) [Pubmed]
Novel Rearranged Abietane Diterpenoids from the Roots of Salvia sahendica. Jassbi, A.R., Mehrdad, M., Eghtesadi, F., Ebrahimi, S.N., Baldwin, I.T. Chem. Biodivers. (2006) [Pubmed]
Effects of horminone on liver mixed function mono-oxygenases and glutathione enzyme activities of Wistar rat. Ferreira, R., Candeias, F., Simões, F., Nascimento, J., Cruz Morais, J. Journal of ethnopharmacology. (1997) [Pubmed]
Effect of tingenone, a quinonoid triterpene, on growth and macromolecule biosynthesis in Trypanosoma cruzi. Goijman, S.G., Turrens, J.F., Marini-Bettolo, G.B., Stoppani, A.O. Experientia (1985) [Pubmed]

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