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Chemical Compound Review

HORMINON     1,10-dihydroxy-4b,8,8- trimethyl-2-propan-2...

Synonyms: Horminone, TAXOQUINONE, NSC-122418, NSC-294577, NSC122418, ...
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Disease relevance of Horminone


High impact information on Horminone

  • Indeed, horminone, bonded to [Mg(H(2)O)(4)](2+), is able to cross the bacterial membrane cell [2].
  • Eight diterpenoids, trilobinol ( 1), trilobinone ( 2), ferruginol, horminone, 7alpha-acetylroyleanone, 6beta-hydroxyroyleanone, virgatol and cryptanol were isolated from the roots of SALVIA TRILOBA L. fil [3].
  • Two naphthoquinone diterpenoids, 1 and 2, one tricyclic, and one tetracyclic rearranged abietane ('4,5-seco-10,5-friedo-abietane') diterpenoids, 3 and 4, respectively, together with horminone (5) have been isolated from the roots of Salvia sahendica [4].
  • On the one hand, results showed that horminone increased serum ALT and AST levels and cyt b5 content and induced the activities of ethylmorphine N-demethylase (EMD) [5].
  • Horminone is a diterpenoid quinone (7,12-dihydroxyabiet-8,12-diene-11,14-dione) present in several species of the Labiatae family and used as medicinal plants in folk medicine [5].

Associations of Horminone with other chemical compounds


  1. Antibacterial diterpenes from the roots of Salvia blepharochlaena. Ulubelen, A., Oksüz, S., Topcu, G., Gören, A.C., Voelter, W. J. Nat. Prod. (2001) [Pubmed]
  2. Theoretical study of the complexes of horminone with Mg2+ and Ca2+ ions and their relation with the bacteriostatic activity. Nicolás, I., Castro, M. The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory. (2006) [Pubmed]
  3. New Diterpenoids from the Roots of Salvia triloba. Ulubelen, A. Planta Med. (1990) [Pubmed]
  4. Novel Rearranged Abietane Diterpenoids from the Roots of Salvia sahendica. Jassbi, A.R., Mehrdad, M., Eghtesadi, F., Ebrahimi, S.N., Baldwin, I.T. Chem. Biodivers. (2006) [Pubmed]
  5. Effects of horminone on liver mixed function mono-oxygenases and glutathione enzyme activities of Wistar rat. Ferreira, R., Candeias, F., Simões, F., Nascimento, J., Cruz Morais, J. Journal of ethnopharmacology. (1997) [Pubmed]
  6. Effect of tingenone, a quinonoid triterpene, on growth and macromolecule biosynthesis in Trypanosoma cruzi. Goijman, S.G., Turrens, J.F., Marini-Bettolo, G.B., Stoppani, A.O. Experientia (1985) [Pubmed]
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