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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Food restriction alters pregnancy-associated changes in IGF and IGFBP in the guinea pig.

The effect of moderate food restriction on pregnancy-associated changes in weight gain, body composition, and circulating insulin-like growth factors (IGF) I and II and IGF-binding proteins (IGFBP)-1 through-4 and their relationship was determined in the guinea pig. Pregnancy did not stimulate weight gain but reduced fat deposition in ad libitum-fed animals and increased weight gain and fat deposition in food-restricted animals relative to their respective virginal group. Pregnancy increased the abundance of circulating IGF-I regardless of food intake and increased that of IGF-II in food-restricted animals only. Pregnancy also increased circulating IGFBP-1 and -2 in ad libitum-fed and food-restricted animals and IGFBP-4 in ad libitum-fed animals. Multiple regression analysis showed that maternal weight gain was negatively associated with circulating IGF-II and IGFBP-2. Fetal weight was positively associated with maternal circulating IGF-II and negatively associated with maternal circulating IGFBP-1 and -2. Significant interactions indicate, however, that the role of IGF-II and IGFBP-1 on fetal growth is dependent on the nutritional status of the mother.[1]


  1. Food restriction alters pregnancy-associated changes in IGF and IGFBP in the guinea pig. Sohlström, A., Katsman, A., Kind, K.L., Roberts, C.T., Owens, P.C., Robinson, J.S., Owens, J.A. Am. J. Physiol. (1998) [Pubmed]
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