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Gene Review

IGFBP2  -  insulin-like growth factor binding protein...

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Disease relevance of IGFBP2


High impact information on IGFBP2


Biological context of IGFBP2

  • The present study examined whether IGF-II and a major uterine-expressed IGF-II binding protein, IGFBP-2, modulate endometrial epithelial cell mitogenesis [9].
  • At equimolar concentrations, Des(1-6)IGF-II (an IGF-II analog with much reduced affinity for IGFBPs) and rpIGFBP-2 had additive effects on GE cell mitogenesis, suggesting that the IGFBP-2 modulation of uterine cell growth may involve both IGF-dependent and IGF-independent pathways [9].
  • Hepatic IGFBP-2 mRNA and serum IGFBP-2 levels increased during the latter half of gestation and then declined postnatally [10].
  • Gene expression for IGFBP-d decreased (P < 0.04) from day 3 to day 5, while expression of IGFBP-2 was unaffected by treatment or day [11].
  • In summary, increased fetal growth in somatotropin-treated pregnant pigs was not associated with changes in IGF or IGFBP-2 mRNA concentration in reproductive tissues [12].

Anatomical context of IGFBP2


Associations of IGFBP2 with chemical compounds

  • IGFBP-2 mRNA was correlated with both day and diameter (r = -.713 and -.705, respectively, n = 24) and neither estrogen (E2) nor progesterone (P4) contributed to the fit [14].
  • Regression analysis of IGF-I and IGFBP-2 mRNA expression was performed to assess the relative strength of correlations with day, diameter and steroid concentrations as covariates [14].
  • In experiment 3, progesterone remained elevated from 0 to 36 h after hCG, even though IGFBP-2 did not increase until after 24 h post-hCG.(ABSTRACT TRUNCATED AT 250 WORDS)[15]
  • In experiments 1 and 2, IGFBP-3 in follicular fluid remained constant over follicle diameters and stage sof development, and IGFBP-2 decreased with advancing follicular development as concentrations of estradiol, androstenedione, and progesterone increased [15].
  • We therefore examined the associations between placental structural parameters, the ratios of maternal to fetal plasma glucose and fetal to maternal plasma urea concentration, and maternal circulating IGF-I, IGF-II and IGFBP-2 in ad libitum fed and food restricted (70-90 per cent of the ad libitum intake) pregnant guinea pigs [3].

Physical interactions of IGFBP2


Regulatory relationships of IGFBP2

  • GH for either 20 days or 40 days increased serum IGBP-3 to 140% and 250% of control values while decreasing serum IGFBP-2 by 46% and 31%, respectively (p < 0.001) [17].

Other interactions of IGFBP2

  • IUGR was associated with elevated plasma IGFBP-2 and IGFBP-4 and reduced IGFBP-3 levels [2].
  • Ligand blot analysis of granulosa cell (GC)-conditioned culture medium revealed several easily measurable insulin-like growth factor (IGF)-binding proteins (IGFBPs), including IGFBP-3 [40-44 kilodaltons (kDa)] and IGFBP-2 (34 kDa) [18].
  • The mRNA for IGF-I, IGF-II, IGFBP-2, LH receptor, FSH receptor, cytochrome P450 side-chain cleavage (P450scc), 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD), 17 alpha-hydroxylase (P45017 alpha), and aromatase (P450arom) were detected by in situ hybridization, and relative amounts were determined by image analysis [19].
  • IGF-I, IGFBP-2 and -3 but not GH concentrations are different in normal and poor growing piglets [20].
  • Serum GH, IGF-I, IGF-II and IGFBP-2 concentrations were determined by radioimmunoassay in swine of genetic lines which were selected for high (obese) and low (lean) backfat [21].

Analytical, diagnostic and therapeutic context of IGFBP2


  1. Depletion of insulin in streptozocin-induced-diabetic pigs alters estradiol, insulin-like growth factor (IGF)-I and IGF binding proteins in cultured ovarian follicles. Edwards, J.L., Hughey, T.C., Moore, A.B., Cox, N.M. Biol. Reprod. (1996) [Pubmed]
  2. Altered expression of IGFs and IGF-binding proteins during intrauterine growth restriction in guinea pigs. Carter, A.M., Kingston, M.J., Han, K.K., Mazzuca, D.M., Nygard, K., Han, V.K. J. Endocrinol. (2005) [Pubmed]
  3. Altered placental structure induced by maternal food restriction in guinea pigs: a role for circulating IGF-II and IGFBP-2 in the mother? Roberts, C.T., Sohlstrom, A., Kind, K.L., Grant, P.A., Earl, R.A., Robinson, J.S., Khong, T.Y., Owens, P.C., Owens, J.A. Placenta (2001) [Pubmed]
  4. Food restriction alters pregnancy-associated changes in IGF and IGFBP in the guinea pig. Sohlström, A., Katsman, A., Kind, K.L., Roberts, C.T., Owens, P.C., Robinson, J.S., Owens, J.A. Am. J. Physiol. (1998) [Pubmed]
  5. Porcine aortic smooth muscle cells secrete a serine protease for insulin-like growth factor binding protein-2. Gockerman, A., Clemmons, D.R. Circ. Res. (1995) [Pubmed]
  6. Differential expression and biological effects of insulin-like growth factor-binding protein-4 and -5 in vascular smooth muscle cells. Duan, C., Clemmons, D.R. J. Biol. Chem. (1998) [Pubmed]
  7. Insulin-like growth factor-I (IGF-I) regulates IGF-binding protein-5 synthesis through transcriptional activation of the gene in aortic smooth muscle cells. Duan, C., Hawes, S.B., Prevette, T., Clemmons, D.R. J. Biol. Chem. (1996) [Pubmed]
  8. Selective expression of insulin-like growth factor system components during porcine ovary follicular selection. Zhou, J., Adesanya, O.O., Vatzias, G., Hammond, J.M., Bondy, C.A. Endocrinology (1996) [Pubmed]
  9. Complex mediation of uterine endometrial epithelial cell growth by insulin-like growth factor-II (IGF-II) and IGF-binding protein-2. Badinga, L., Song, S., Simmen, R.C., Clarke, J.B., Clemmons, D.R., Simmen, F.A. J. Mol. Endocrinol. (1999) [Pubmed]
  10. Ontogeny of the porcine insulin-like growth factor system. Lee, C.Y., Chung, C.S., Simmen, F.A. Mol. Cell. Endocrinol. (1993) [Pubmed]
  11. Influence of insulin on follicular development and the intrafollicular insulin-like growth factor I (IGF-I) system in sows after weaning. Whitley, N.C., Quirk-Thomas, M.N., Skelton, J.O., Moore, A.B., Purvis, J., Qui, Y., Cox, N.M. J. Reprod. Fertil. (1998) [Pubmed]
  12. Insulin-like growth factor (IGF)-I, IGF-II, IGF-binding protein-2 and pregnancy-associated glycoprotein mRNA in pigs with somatotropin-enhanced fetal growth. Sterle, J.A., Boyd, C., Peacock, J.T., Koenigsfeld, A.T., Lamberson, W.R., Gerrard, D.E., Lucy, M.C. J. Endocrinol. (1998) [Pubmed]
  13. Differential expression, during the estrous cycle and pre- and postimplantation conceptus development, of messenger ribonucleic acids encoding components of the pig uterine insulin-like growth factor system. Simmen, F.A., Simmen, R.C., Geisert, R.D., Martinat-Botte, F., Bazer, F.W., Terqui, M. Endocrinology (1992) [Pubmed]
  14. Expression of the mRNAs for the insulin-like growth factors and their binding proteins during development of porcine ovarian follicles. Samaras, S.E., Guthrie, H.D., Barber, J.A., Hammond, J.M. Endocrinology (1993) [Pubmed]
  15. Relationships among concentrations of steroids, inhibin, insulin-like growth factor-1 (IGF-1), and IGF-binding proteins during follicular development in weaned sows. Howard, H.J., Ford, J.J. Biol. Reprod. (1992) [Pubmed]
  16. Gonadotropin and cAMP modulation of IGE binding protein production in ovarian granulosa cells. Grimes, R.W., Samaras, S.E., Barber, J.A., Shimasaki, S., Ling, N., Hammond, J.M. Am. J. Physiol. (1992) [Pubmed]
  17. Effects of growth hormone and gonadotropin on the insulin-like growth factor system in the porcine ovary. Samaras, S.E., Hagen, D.R., Bryan, K.A., Mondschein, J.S., Canning, S.F., Hammond, J.M. Biol. Reprod. (1994) [Pubmed]
  18. Insulin and insulin-like growth factors (IGFs) stimulate production of IGF-binding proteins by ovarian granulosa cells. Grimes, R.W., Hammond, J.M. Endocrinology (1992) [Pubmed]
  19. Messenger ribonucleic acid for insulin-like growth factors-I and -II, insulin-like growth factor-binding protein-2, gonadotropin receptors, and steroidogenic enzymes in porcine follicles. Yuan, W., Lucy, M.C., Smith, M.F. Biol. Reprod. (1996) [Pubmed]
  20. IGF-I, IGFBP-2 and -3 but not GH concentrations are different in normal and poor growing piglets. Saleri, R., Baratta, M., Mainardi, G.L., Renaville, R., Giustina, A., Quintavalla, F., Tamanini, C. Reprod. Nutr. Dev. (2001) [Pubmed]
  21. Ontogeny of growth hormone (GH), insulin-like growth factors (IGF-I and IGF-II) and IGF binding protein-2 (IGFBP-2) in genetically lean and obese swine. Buonomo, F.C., Klindt, J. Domest. Anim. Endocrinol. (1993) [Pubmed]
  22. Relaxin increases insulin-like growth factors (IGFs) and IGF-binding proteins of the pig uterus in vivo. Ohleth, K.M., Lenhart, J.A., Ryan, P.L., Radecki, S.V., Bagnell, C.A. Endocrinology (1997) [Pubmed]
  23. The effects of thyroxine on serum and tissue concentrations of insulin-like growth factors (IGF-I and -II) and IGF-binding proteins in the fetal pig. Latimer, A.M., Hausman, G.J., McCusker, R.H., Buonomo, F.C. Endocrinology (1993) [Pubmed]
  24. Changes in insulin-like growth factor-binding protein-2 and -3 in follicular fluid during atresia of follicles grown after ovulation in pigs. Guthrie, H.D., Grimes, R.W., Hammond, J.M. J. Reprod. Fertil. (1995) [Pubmed]
  25. Short-term infusion of LongR(3) insulin-like growth factor (IGF)-I decreases hepatic IGF-I mRNA but not IGF binding protein-3 mRNA expression in pigs. Dunaiski, V., Dunshea, F.R., Walton, P.E., Goddard, C. Gen. Comp. Endocrinol. (2002) [Pubmed]
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